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Showing 1–4 of 4 results
Advanced filters: Author: Rylan J. Lundgren Clear advanced filters

  • Carbon-labelled α-amino acids are valuable compounds in drug development and nuclear medicine, but are difficult and time consuming to prepare. Now, an aldehyde-catalysed method has been developed for the direct C1-labelling of α-amino acids using *CO2 (* = 14, 13, 11), providing access to many proteinogenic and non-natural labelled α-amino acids.

    • Odey Bsharat
    • Michael G. J. Doyle
    • Rylan J. Lundgren
    Research
    Nature Chemistry
    Volume: 14, P: 1367-1374

  • Preparing molecules with multiple 13C labels is difficult owing to the lack of available 13C-labelled reagents. Now, a hydroformylation approach to the synthesis of [13C3]propionaldehyde, using gas surrogates, provides a straightforward method to prepare bioactive molecules with three 13C labels.

    • Michael G. J. Doyle
    • Rylan J. Lundgren
    News & Views
    Nature Synthesis
    Volume: 2, P: 205-206

  • Radical intermediates are key species in many chemical transformations. Recent advances have provided a new suite of selective radical alkylation reactions. This Comment highlights pioneering studies using alkyl amines that act as radical precursors in a number of catalytic processes by their conversion to alkylpyridinium salts.

    • Duanyang Kong
    • Patrick J. Moon
    • Rylan J. Lundgren
    Comments & Opinion
    Nature Catalysis
    Volume: 2, P: 473-476