Nature Search

Effective treatment of malignant hypercalcaemia with a single intravenous infusion of clodronate

NP O'Rourke
EV McCloskey
JA Kanis
Research01 Mar 1993
British Journal of Cancer

Volume: 67, P: 560-563
Federated learning enables big data for rare cancer boundary detection

Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here, the authors present the largest FL study to-date to generate an automatic tumor boundary detector for glioblastoma.

Sarthak Pati
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access05 Dec 2022
Nature Communications

Volume: 13, P: 1-17
Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree

James L. Kennedy
Luis A. Giuffra
Kenneth K. Kidd
Research10 Nov 1988
Nature

Volume: 336, P: 167-170
Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons

Christopher A. Ross
Jacopo Meldolesi
Solomon H. Snyder
Research08 Jun 1989
Nature

Volume: 339, P: 468-470
A rectal cancer organoid platform to study individual responses to chemoradiation

Rectal cancer organoids retain the pathological features of matched patient tumors and recapitulate clinical responses to chemoradiation.

Karuna Ganesh
Chao Wu
J. Joshua Smith
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1607-1614
Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial

Bagley et al. conduct a phase 1 trial to study safety and tolerability of CAR T-EGFRvIII cells administered concomitantly with PD-1 inhibition via pembrolizumab in patients with glioblastoma and show tolerability, but without signs of efficacy.

Stephen J. Bagley
Zev A. Binder
Donald M. O’Rourke
Research12 Jan 2024
Nature Cancer

Volume: 5, P: 517-531
NINJ1 mediates plasma membrane rupture during lytic cell death

The small transmembrane protein NINJ1 promotes plasma membrane rupture in lytic cell death associated with pyroptosis, necrosis and apoptosis.

Nobuhiko Kayagaki
Opher S. Kornfeld
Vishva M. Dixit
Research20 Jan 2021
Nature

Volume: 591, P: 131-136
Evidence from Cd/Ca ratios in foraminifera for greater upwelling off California 4,000 years ago

A. van Geen
S. N. Luoma
S. Trumbore
Research02 Jul 1992
Nature

Volume: 358, P: 54-56
Weak magnetism of Martian impact basins may reflect cooling in a reversing dynamo

Weak magnetic fields above Mars’s large impact basins are often interpreted as a signature of the dynamo’s early cessation. Here, the authors demonstrate that these weakly magnetic basins may instead have formed in a long-lived but reversing dynamo.

S. C. Steele
R. R. Fu
R. J. Lillis
ResearchOpen Access09 Aug 2024
Nature Communications

Volume: 15, P: 1-16
High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange

Peptide-MHC (pMHC) tetramers are important tools for probing T cell repertoire and adaptive immune responses. Here the authors use a molecular chaperone, TAPBPR, to develop a high-throughput, multiplexible platform for pMHC tetramer generation to facilitate simultaneous assessments of T cell repertoire/antigen specificity and transcriptome.

Sarah A. Overall
Jugmohit S. Toor
Nikolaos G. Sgourakis
ResearchOpen Access20 Apr 2020
Nature Communications

Volume: 11, P: 1-13
Source sector and fuel contributions to ambient PM_2.5 and attributable mortality across multiple spatial scales

Ambient fine particulate matter (PM_2.5) is one of the most important environmental health risk factors in many regions. Here, the authors present an assessment of PM_2.5 emission sources and the related health impacts across global to sub-national scales and find that over 1 million deaths were avoidable in 2017 by eliminating PM_2.5 mass associated with fossil fuel combustion emissions.

Erin E. McDuffie
Randall V. Martin
Michael Brauer
ResearchOpen Access14 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours

Uveal melanoma has a propensity to metastasise. Here, the authors report the whole genome sequence of 103 uveal melanomas and find that the tumour mutational burden is variable and that two subsets of tumours are characterised by MBD4 mutations and a UV exposure signature.

Peter A. Johansson
Kelly Brooks
Nicholas K. Hayward
ResearchOpen Access15 May 2020
Nature Communications

Volume: 11, P: 1-8
The National Lung Matrix Trial of personalized therapy in lung cancer

Current outcomes are reported from the ongoing National Lung Matrix Trial, an umbrella trial for the treatment of non-small-cell lung cancer in which patients are triaged according to their tumour genotype and matched with targeted therapeutic agents.

Gary Middleton
Peter Fletcher
Lucinda Billingham
Research15 Jul 2020
Nature

Volume: 583, P: 807-812
Oxygen Extraction in Lamb Skeletal Muscle

Marc B Hershenson
Pearl P O'rourke
Robert K Crone
Research01 Aug 1990
Pediatric Research

Volume: 28, P: 101-105
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

A monoclonal antibody that binds NINJ1 and inhibits NINJ1 oligomerization prevents plasma membrane rupture in dying cells, resulting in decreased inflammation of surrounding tissue in mice.

Nobuhiko Kayagaki
Irma B. Stowe
Vishva M. Dixit
ResearchOpen Access17 May 2023
Nature

Volume: 618, P: 1072-1077
Role of CED-4 in the activation of CED-3

Arul M. Chinnaiyan
Divya Chaudhary
Vishva M. Dixit
Research21 Aug 1997
Nature

Volume: 388, P: 728-729
Interplanar coupling-dependent magnetoresistivity in high-purity layered metals

In Weyl semimetals, unusual electronic transport phenomena are predicted to occur, such as an axial anomaly which violates the conservation of chiral fermions. Here, the authors evidence such behaviour via the occurrence of negative magnetoresistance in layered high-purity non-magnetic metals.

N. Kikugawa
P. Goswami
L. Balicas
ResearchOpen Access29 Mar 2016
Nature Communications

Volume: 7, P: 1-8
Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

Robert Lu
Julienne J. O’Rourke
Hilda A. Pickett
Amendments and CorrectionsOpen Access20 Nov 2019
Nature Communications

Volume: 10, P: 1
Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study

Results from the LAVENDER phase 3 study demonstrate that trofinetide, a synthetic analog of glycine–proline–glutamate, provides significant therapeutic benefits in the core symptoms of Rett syndrome

Jeffrey L. Neul
Alan K. Percy
James M. Youakim
ResearchOpen Access08 Jun 2023
Nature Medicine

Volume: 29, P: 1468-1475
Genetic and transcriptional evolution alters cancer cell line drug response

The extent, origins and consequences of genetic variation within human cell lines are studied, providing a framework for researchers to measure such variation in efforts to support maximally reproducible cancer research.

Uri Ben-David
Benjamin Siranosian
Todd R. Golub
Research08 Aug 2018
Nature

Volume: 560, P: 325-330
Cryopyrin activates the inflammasome in response to toxins and ATP

Sanjeev Mariathasan
David S. Weiss
Vishva M. Dixit
Research11 Jan 2006
Nature

Volume: 440, P: 228-232
Cognitive criteria in HIV: greater consensus is needed

Lucette A. Cysique
Bruce J. Brew
Sean B. Rourke
Correspondence16 Jan 2024
Nature Reviews Neurology

Volume: 20, P: 127-128
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

BET-bromodomain inhibitors could be used to treat medulloblastoma tumors with Myc amplifications. Here, the authors show that both the response and resistance to BET inhibitors in mice is mediated by bHLH/homeobox transcription factors.

Pratiti Bandopadhayay
Federica Piccioni
Rameen Beroukhim
ResearchOpen Access03 Jun 2019
Nature Communications

Volume: 10, P: 1-16
Artificial vision

Mark S Humayun
Eugene de Juan Jr
Research01 May 1998
Eye

Volume: 12, P: 605-607
Accurate whole human genome sequencing using reversible terminator chemistry

David R. Bentley
Shankar Balasubramanian
Anthony J. Smith
ResearchOpen Access06 Nov 2008
Nature

Volume: 456, P: 53-59
Drivers and implications of alternative routes to fuels decarbonization in net-zero energy systems

Assumptions about the use of biomass and CO₂ sequestration drive key differences in how emissions from remaining fuels are mitigated in net-zero energy systems, with potentially significant tradeoffs that will need to be evaluated and managed.

Bryan K. Mignone
Leon Clarke
Aranya Venkatesh
ResearchOpen Access10 May 2024
Nature Communications

Volume: 15, P: 1-14
Erratum: Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

Daniel S. Peeper
Todd M. Upton
Mark E. Ewen
Amendments and Corrections03 Apr 1997
Nature

Volume: 386, P: 521
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
Determining eigenstates and thermal states on a quantum computer using quantum imaginary time evolution

The quantum imaginary time evolution and Lanczos algorithms offer a resource-efficient way to compute ground or excited states of target Hamiltonians on quantum computers. This offers promise for quantum simulation on near-term noisy devices.

Mario Motta
Chong Sun
Garnet Kin-Lic Chan
Research11 Nov 2019
Nature Physics

Volume: 16, P: 205-210
Risk factors for intellectual and educational sequelae of cranial irradiation in childhood acute lymphoblastic leukaemia

E Smibert
V Anderson
H Ekert
Research01 Mar 1996
British Journal of Cancer

Volume: 73, P: 825-830
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Gasdermin D is identified as the required substrate for pyroptosis, mediating caspase-11 function in the non-canonical inflammasome pathway; the cleaved N-terminal domain is shown to trigger pyroptosis.

Nobuhiko Kayagaki
Irma B. Stowe
Vishva M. Dixit
Research16 Sept 2015
Nature

Volume: 526, P: 666-671
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Ingrid E. Wertz
Saritha Kusam
Vishva M. Dixit
Research02 Mar 2011
Nature

Volume: 471, P: 110-114
The Effect of Naloxone on the Hemodynamics of the Newborn Piglet with Septic Shock

Randy R Miller
James A Menke
Philip T Nowicki
Research01 Aug 1986
Pediatric Research

Volume: 20, P: 707-710
High Milk Lipase Activity Associated with Breast Milk Jaundice

Ronald L Poland
Gary E Schultz
Gayatri Garg
Research01 Dec 1980
Pediatric Research

Volume: 14, P: 1328-1331
Polygenic control of Caenorhabditis elegans fat storage

Ho Yi Mak
Laura S Nelson
Gary Ruvkun
Research05 Feb 2006
Nature Genetics

Volume: 38, P: 363-368
Deep mitigation of CO₂ and non-CO₂ greenhouse gases toward 1.5 °C and 2 °C futures

Stabilizing climate change requires simultaneous mitigation of all greenhouse gas emissions (GHGs). Here the authors examine 90 mitigation scenarios pairing different levels of CO₂ and non-CO₂ GHG abatement pathways to demonstrate the contributions of different GHGs towards 1.5 °C and 2 °C goals.

Yang Ou
Christopher Roney
Haewon McJeon
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-9
Comparative Hemodynamic Effects of Isoproterenol, Dopamine, and Dobutamine in the Newborn Dog

David J Driscoll
Paul C Gillette
Frank Dunn
Research01 Sept 1979
Pediatric Research

Volume: 13, P: 1006-1009
Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MR Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma

S. Ali Nabavizadeh
Hamed Akbari
Christos Davatzikos
ResearchOpen Access19 Jun 2019
Scientific Reports

Volume: 9, P: 1-8
Abnormal Heart Rate Characteristics Preceding Neonatal Sepsis and Sepsis-Like Illness

M Pamela Griffin
T Michael O'Shea
J Randall Moorman
Research01 Jun 2003
Pediatric Research

Volume: 53, P: 920-926
T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

Kohei Ota
Makoto Matsui
David A. Hafler
Research12 Jul 1990
Nature

Volume: 346, P: 183-187
A specific requirement for PDGF-C in palate formation and PDGFR-α signaling

Hao Ding
Xiaoli Wu
Andras Nagy
Research07 Sept 2004
Nature Genetics

Volume: 36, P: 1111-1116
The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers

Kazerooni et al. explore the associations between tumor imaging and spatial characteristics with cancer gene mutations and the inferred sequence of mutational events. Radiogenomics reflects glioblastoma's molecular heterogeneity and imaging biomarkers and spatial patterns can reveal key oncogenic drivers.

Anahita Fathi Kazerooni
Hamed Akbari
Christos Davatzikos
ResearchOpen Access01 Mar 2025
Communications Medicine

Volume: 5, P: 1-15
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Cox and colleagues develop PXS-5505, a first-in-class selective pan-lysyl oxidase inhibitor and show that it reduces chemotherapy-induced desmoplasia and stiffness, thereby improving chemotherapy response and survival in pancreatic cancer models.

Jessica L. Chitty
Michelle Yam
Thomas R. Cox
ResearchOpen Access28 Aug 2023
Nature Cancer

Volume: 4, P: 1326-1344
Peak SIV replication in resting memory CD4⁺ T cells depletes gut lamina propria CD4⁺ T cells

Qingsheng Li
Lijie Duan
Ashley T. Haase
Research27 Mar 2005
Nature

Volume: 434, P: 1148-1152
Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy

Turk and colleagues analyze exceptional responders to checkpoint blockade for melanoma, and detect tissue-resident memory and effector memory T-cell clonotypes in skin and blood, respectively, up to 9 years after treatment.

Jichang Han
Yanding Zhao
Christina V. Angeles
Research24 Mar 2021
Nature Cancer

Volume: 2, P: 300-311
P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas

Chimeric antigen receptor (CAR) T cell therapy has been proposed as a promising approach for treating glioblastoma. Here the authors show that p32 is expressed in murine and human glioma and that p32-directed CAR-T cells promote anti-tumor responses in preclinical models by targeting glioma cells and tumor derived endothelial cells.

Liat Rousso-Noori
Ignacio Mastandrea
Dinorah Friedmann-Morvinski
ResearchOpen Access14 Jun 2021
Nature Communications

Volume: 12, P: 1-13
Adult and children's exposure to 2,4-D from multiple sources and pathways

Marsha K Morgan
Linda S Sheldon
Nancy K Wilson
Research02 Jan 2008
Journal of Exposure Science & Environmental Epidemiology

Volume: 18, P: 486-494
PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2

Cardiomyocyte maturation and the acquisition of phenotypes is poorly understood at the single cell level. Here, the authors analyse the transcriptome of single cells from neonatal to adult heart and reveal that peroxisome proliferator-activated receptor coactivator-1 mediates the phenotypic shift.

Sean A. Murphy
Matthew Miyamoto
Chulan Kwon
ResearchOpen Access12 Mar 2021
Nature Communications

Volume: 12, P: 1-12
Antibody-mediated enhancement of rabies virus

J.S. Porterfield
News & Views16 Apr 1981
Nature

Volume: 290, P: 542
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

Macrophages in the tumour microenvironment (TME) acquire tumour-promoting functions upon M2 polarization. Here the authors show, in a mouse model of glioblastoma, that endothelial cells in the TME induce macrophage M2 polarization via IL-6 and that depletion of endothelial IL-6 improves survival.

Qirui Wang
Zhenqiang He
Yi Fan
ResearchOpen Access08 Feb 2018
Nature Communications

Volume: 9, P: 1-15

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