Genetic and molecular research has improved our understanding of the mechanisms underlying lipodystrophy, a disorder characterized by complete or partial loss of adipose tissue. This Review describes the various types of lipodystrophy syndromes known to date, as well as mechanisms responsible for concomitant metabolic abnormalities, and provides a perspective on current treatment options and novel therapeutic approaches, with a focus on the adipokines leptin and adiponectin.
- Christina G. Fiorenza
- Sharon H. Chou
- Christos S. Mantzoros
