Nature Search

Expansion and fluctuations-enhanced microscopy for nanoscale molecular profiling of cells and tissues

The combination of expansion microscopy with enhanced super-resolution radial fluctuations analysis enhances the image resolution of a conventional microscope to 25 nm in clinical and experimental samples.

Dominik Kylies
Hannah S. Heil
Ricardo Henriques
Protocols02 Jul 2025
Nature Protocols

P: 1-33
The origin of the major cystic fibrosis mutation (ΔF508) in European populations

N. Morral
J. Bertranpetit
L. Kadasi
Research01 Jun 1994
Nature Genetics

Volume: 7, P: 169-175
Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band

Jordi Frigola
Jenny Song
Susan J Clark
Research23 Apr 2006
Nature Genetics

Volume: 38, P: 540-549
A mutualistic interaction between Streptomyces bacteria, strawberry plants and pollinating bees

Microbes can establish mutualistic interactions with plants and insects. Here, Kim et al. show that Streptomyces bacteria can protect strawberry plants and honeybees from pathogens, can move into the plant vascular tissue from soil and from flowers, and are transferred among flowers by the pollinators.

Da-Ran Kim
Gyeongjun Cho
Youn-Sig Kwak
ResearchOpen Access22 Oct 2019
Nature Communications

Volume: 10, P: 1-10
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

Infection or chronic inflammation is a risk factor for childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors show that the DNA editing enzyme AID is expressed in infected B cells but using genetic mouse models show that it does not contribute to leukemia pathogenesis.

Guillermo Rodríguez-Hernández
Friederike V. Opitz
Arndt Borkhardt
ResearchOpen Access05 Dec 2019
Nature Communications

Volume: 10, P: 1-10
Macrophages protect against sensory axon loss in peripheral neuropathy

A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.

Sara Hakim
Aakanksha Jain
Clifford J. Woolf
ResearchOpen Access12 Feb 2025
Nature

Volume: 640, P: 212-220
Cytopathic Effects of the Parainfluenza Virus SV₅ in Vero Cells

JOHAG S. RHIM
KLAUS SCHELL
Research21 Oct 1967
Nature

Volume: 216, P: 271-272
Diversity oriented biosynthesis via accelerated evolution of modular gene clusters

Reengineering polyketide synthase encoding genes to produce analogues of natural products can be slow and low-yielding. Here the authors use accelerated evolution to recombine the gene cluster for rapid production of rapamycin-related products.

Aleksandra Wlodek
Steve G. Kendrew
Matthew A. Gregory
ResearchOpen Access31 Oct 2017
Nature Communications

Volume: 8, P: 1-10
Neutron Activation Analyses of Snake Venoms: Presence of Copper

S. GITTER
S. AMIEL
Y. WELWART
Research26 Jan 1963
Nature

Volume: 197, P: 383-384
A fossil smut fungus from the anthers of an Eocene angiosperm

R. S. Currah
R. A. Stockey
Research25 Apr 1991
Nature

Volume: 350, P: 698-699
Drug-Resistance Shown by Trypanosomes Following 'Antrycide' Treatment

S. G. WILSON
Research04 Jun 1949
Nature

Volume: 163, P: 873-874
Ongoing declines for the world’s amphibians in the face of emerging threats

The second Global Amphibian Assessment finds that the status of amphibians is continuing to deteriorate globally, driven predominantly by climate change, disease and habitat loss.

Jennifer A. Luedtke
Janice Chanson
Simon N. Stuart
ResearchOpen Access04 Oct 2023
Nature

Volume: 622, P: 308-314
Non-antigenicity of Gelatin

A. WORMALL
Research09 Sept 1944
Nature

Volume: 154, P: 332
Influence of Streptomycin and Mineral Salts in the Action of Ribonuclease

G. CERIOTTI
Research04 Jun 1949
Nature

Volume: 163, P: 874
A Mucolytic Enzyme in Testis Extracts

E. CHAIK
E. S. DUTHIE
Research09 Dec 1939
Nature

Volume: 144, P: 977-978
Cause of the ‘inhibitor’ phenotype in the haemophilias

F. GIANNELLI
G. G. BROWNLEE
Research13 Mar 1986
Nature

Volume: 320, P: 196
Antibody Production in Mice with Isologous Tumours

W. DAVID MACKAY
Research18 Sept 1965
Nature

Volume: 207, P: 1306-1307
MLL oncoprotein levels influence leukemia lineage identities

The effects of chromosomal translocations involving the mixed-lineage leukemia (MLL) locus on gene expression regulation remain to be explored. Here, the authors find that MLL oncoproteins support lineage-switching events through dynamic chromatin binding.

Derek H. Janssens
Melodie Duran
Steven Henikoff
ResearchOpen Access29 Oct 2024
Nature Communications

Volume: 15, P: 1-13
Deciphering the genetics and mechanisms of predisposition to multiple myeloma

Multiple myeloma (MM) is an incurable blood malignancy. Here, the authors report 35 MM risk loci and two causal mechanisms for genetic MM risk: longer telomeres and elevated plasma B-cell maturation antigen (BCMA) and interleukin−5 receptor alpha (IL5RA) levels.

Molly Went
Laura Duran-Lozano
Björn Nilsson
ResearchOpen Access05 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Coelomic Water Volume Control in the Antarctic Sea-star Odontaster validus

J. S. PEARSE
Research01 Dec 1967
Nature

Volume: 216, P: 1118-1119
Children’s and adolescents’ rising animal-source food intakes in 1990–2018 were impacted by age, region, parental education and urbanicity

An analysis based on data from the Global Dietary Database shows mean animal-sourced food intakes among children and adolescents increased modestly from 1990 to two portions per day in 2018, but remain low in sub-Saharan Africa, India and Bangladesh.

Victoria Miller
Patrick Webb
Rubina Hakeem
ResearchOpen Access20 Apr 2023
Nature Food

Volume: 4, P: 305-319
The crystallization water of gypsum rocks is a relevant water source for plants

Some minerals, such as gypsum, hold water in their crystalline structure. Palacio et al. show that shallow-rooted plants growing on gypsum are able to make use of this crystallization water, suggesting an alternative water source for plants under conditions of severe drought.

Sara Palacio
José Azorín
Juan Pedro Ferrio
Research18 Aug 2014
Nature Communications

Volume: 5, P: 1-7
Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach

Einav and colleagues characterize peripheral immune blood cells from pediatric patients with severe natural dengue infections. Their findings suggest that disease progression is associated with an inflammatory phenotype accompanied by impaired interferon response, defective antigen presentation and regulation of effector lymphocyte responses.

Luca Ghita
Zhiyuan Yao
Shirit Einav
Research23 Oct 2023
Nature Immunology

Volume: 24, P: 2150-2163
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia

Single-cell genomic and transcriptomic analyses of longitudinal samples of patients with Richter syndrome reveal the presence and dynamics of clones driving transformation from chronic lymphocytic leukemia years before clinical manifestation

Ferran Nadeu
Romina Royo
Elías Campo
ResearchOpen Access11 Aug 2022
Nature Medicine

Volume: 28, P: 1662-1671
Effect of energetic ions on edge-localized modes in tokamak plasmas

Edge-localized plasma modes in a tokamak can damage its innermost wall. Simulations now show that fast ions can modify the spatio-temporal structure of these modes. These effects need to be considered in the optimization of control techniques.

J. Dominguez-Palacios
S. Futatani
M. Zuin
ResearchOpen Access06 Jan 2025
Nature Physics

Volume: 21, P: 43-51
Conditions which eliminate Inflammation to Homografts in Rabbits

RICHARD H. ANDRESEN
CLARENCE W. MONROE
DOROTHY A. MADDEN
Research22 Nov 1958
Nature

Volume: 182, P: 1452
Molecular map of chronic lymphocytic leukemia and its impact on outcome

A genomic, transcriptomic and epigenomic analysis of chronic lymphocytic leukemia identifies genetic drivers and molecular subtypes associated with clinical outcomes.

Binyamin A. Knisbacher
Ziao Lin
Gad Getz
Research04 Aug 2022
Nature Genetics

Volume: 54, P: 1664-1674
Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

Analyses of neuroimaging datasets from 5,306 participants across 15 countries found generally larger brain-age gaps in Latin American compared with non-Latin American populations, which were influenced by disparities in socioeconomic and health-related factors.

Sebastian Moguilner
Sandra Baez
Agustin Ibanez
ResearchOpen Access26 Aug 2024
Nature Medicine

Volume: 30, P: 3646-3657
Sugar-sweetened beverage intakes among adults between 1990 and 2018 in 185 countries

Recent estimates of sugar-sweetened beverages (SSBs) intake are generally unavailable. Here the authors show a global SSBs intake of 2.7 servings/week in 2018 in adults (range: 0.7 South Asia, 7.8 Latin America/Caribbean); intakes were higher among males, younger, more educated, and urban adults.

Laura Lara-Castor
Renata Micha
Rubina Hakeem
ResearchOpen Access03 Oct 2023
Nature Communications

Volume: 14, P: 1-19
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance

Necroptosis is a form of cell death characterized by membrane rupture via MLKL oligomerization, although mechanistic details remain unclear. Here, the authors show that MLKL ubiquitylation of K219 facilitates high-order membrane assembly and subsequent rupture, promoting cytotoxicity.

Laura Ramos Garcia
Tencho Tenev
Pascal Meier
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe

Fruit flies need to appropriately respond to mixtures of attractive and repellent odors in their natural environment. Here, the authors propose that lateral inhibition between glomeruli activated by attractants or repulsive odors mediates the appropriate response.

Ahmed A. M. Mohamed
Tom Retzke
Silke Sachse
ResearchOpen Access13 Mar 2019
Nature Communications

Volume: 10, P: 1-17
Experimental evidence of pollination in marine flowers by invertebrate fauna

Marine plants reproduce by hydrophilly, that is, the movement of pollen by water. Here, the authors show that invertebrates can also carry pollen from male to female Thalassia testudinum plants.

Brigitta I. van Tussenbroek
Nora Villamil
Vivianne Solis-Weiss
ResearchOpen Access29 Sept 2016
Nature Communications

Volume: 7, P: 1-6
Targeting CSF-1 signaling between tumor cells and macrophages at TMEM doorways inhibits breast cancer dissemination

Camille L. Duran
Chinmay R. Surve
John S. Condeelis
ResearchOpen Access11 Jul 2025
Oncogene

Volume: 44, P: 3297-3309
Single-cell analysis of regions of interest (SCARI) using a photosensitive tag

The development of a photocage-nanobody based technology enabled in-depth analysis of live cells from tissues while retaining their spatial information.

Anne M. van der Leun
Mirjam E. Hoekstra
Ton N. Schumacher
Research09 Sept 2021
Nature Chemical Biology

Volume: 17, P: 1139-1147
Unforeseen plant phenotypic diversity in a dry and grazed world

Analysis of 20 chemical and morphological plant traits at diverse sites across 6 continents shows that the transition from semi-arid to arid zones is associated with an unexpected 88% increase in trait diversity.

Nicolas Gross
Fernando T. Maestre
Yoann Le Bagousse-Pinguet
Research07 Aug 2024
Nature

Volume: 632, P: 808-814
Paired proteomic analysis reveals protein alterations in sun-exposed skin of professional drivers

Amanda C. Camillo-Andrade
Lucas A. Sales
Paulo C. Carvalho
ResearchOpen Access31 Mar 2025
Scientific Reports

Volume: 15, P: 1-7
Plant DNA polymerases α and δ mediate replication of geminiviruses

Geminiviruses cause substantial damage to crops worldwide. Here Wu et al. show that geminivirus replication relies upon the host DNA polymerases α and δ, which produce double-stranded DNA intermediates and new copies of the viral genome, respectively, and is modulated by the viral C3 protein.

Mengshi Wu
Hua Wei
Rosa Lozano-Durán
ResearchOpen Access13 May 2021
Nature Communications

Volume: 12, P: 1-10
Vulnerability of mineral-associated soil organic carbon to climate across global drylands

Protection afforded by inorganic minerals is assumed to make mineral-associated organic carbon less susceptible to loss under climate change than particulate organic carbon. However, a global study of soil organic carbon from drylands suggests that this is not the case.

Paloma Díaz-Martínez
Fernando T. Maestre
César Plaza
Research30 Jul 2024
Nature Climate Change

Volume: 14, P: 976-982
Tree rings reveal globally coherent signature of cosmogenic radiocarbon events in 774 and 993 CE

Despite their extensive use, the absolute dating of tree-ring chronologies has not hitherto been independently validated at the global scale. Here, the identification of distinct ¹⁴C excursions in 484 individual tree rings, enable the authors to confirm the dating of 44 dendrochronologies from five continents.

Ulf Büntgen
Lukas Wacker
Giles H. F. Young
ResearchOpen Access06 Sept 2018
Nature Communications

Volume: 9, P: 1-7
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
Diagnostic and Therapeutic Implications of Medium-Chain Acylcarnitines in the Medium-Chain Acyl-CoA Dehydrogenase Deficiency

Charles R Roe
David S Millington
Ronald A Chalmers
Research01 May 1985
Pediatric Research

Volume: 19, P: 459-466
Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases

The association between certain mitochondrial DNA variants and increased risk of late-onset diseases in humans could be explained by a direct role of mitochondrial DNA in the regulation of cellular proteostasis.

Na Cai
Aurora Gomez-Duran
Nicole Soranzo
Research23 Aug 2021
Nature Medicine

Volume: 27, P: 1564-1575
Low-dose donor CD8⁺ cells in the CD4-depleted graft prevent allogeneic marrow graft rejection and severe graft-versus-host disease for chronic myeloid leukemia patients in first chronic phase

D Gallardo
J García-López
A Grañena
Research01 Dec 1997
Bone Marrow Transplantation

Volume: 20, P: 945-952
Milestone in predicting core plasma turbulence: successful multi-channel validation of the gyrokinetic code GENE

Plasma turbulence is the main driver to deteriorate the performance of fusion power plants. This work presents an unprecedented comparison of plasma turbulence between experiment and simulation, proving that the gyrokinetic model GENE reached a high level of maturity to predict core turbulence.

Klara Höfler
Tobias Görler
S. Zoletnik
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Adsorption–desorption behavior of the endocrine-disrupting chemical quinestrol in soils

Mingcheng Guo
Qin Lin
Tao Tang
ResearchOpen Access06 Aug 2020
Scientific Reports

Volume: 10, P: 1-9
N₂ production rates limited by nitrite availability in the Bay of Bengal oxygen minimum zone

Nitrogen losses have not been observed in the Bay of Bengal, unlike in other ocean oxygen minimum zones. Chemical and molecular analyses reveal that trace levels of oxygen inhibit nitrate formation, largely preventing microbial N₂ production.

L. A. Bristow
C. M. Callbeck
D. E. Canfield
Research05 Dec 2016
Nature Geoscience

Volume: 10, P: 24-29
Transport of β-Hydroxy-β-Methyl-Glutarate and β-Hydroxbutyrate by Renal Brushborder Membrane Vesicles

Karl S Roth
Marvin S Medow
Jack W London
Research01 Aug 1982
Pediatric Research

Volume: 16, P: 644-648
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome

Administration of exogenous mitochondria from mice or humans, or stimulation of mitochondria transfer from haematopoietic cells through bone marrow transplant from wild-type mice, is shown to improve morbidity and mortality in a mouse model of the mitochondrial disease Leigh syndrome.

Ritsuko Nakai
Stella Varnum
Jonathan R. Brestoff
Research02 Sept 2024
Nature Metabolism

Volume: 6, P: 1886-1896
Induction of erythroid leukaemia by Harvey and Kirsten sarcoma viruses

CHARLES D. SCHER
EDWARD M. SCOLNICK
RICHARD SIEGLER
Research17 Jul 1975
Nature

Volume: 256, P: 225-226
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477

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