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Showing 1–50 of 57 results

Advanced filters: Author: S E Dobbins Clear advanced filters

An emerging protagonist: Sodium Glucose Co-transporters (SGLTs) as a burgeoning target for the treatment of diabetes mellitus

Danish Ahmed
Manju Sharma
Pankaj S Yadav
ResearchOpen Access02 Apr 2012
Nature Precedings

P: 1
Androgen transport and receptor mechanisms in testis and epididymis

V. Hansson
O. Trygstad
E. M. Ritzén
Research02 Aug 1974
Nature

Volume: 250, P: 387-391
Endstopped neurons in the visual cortex as a substrate for calculating curvature

Allan Dobbins
Steven W. Zucker
Max S. Cynader
Research01 Oct 1987
Nature

Volume: 329, P: 438-441
Hyperoxaluria in chronic renal disease associated with spinal cord injury

N D Vaziri
B Nikakhtar
S Gordon
Research01 Feb 1982
Spinal Cord

Volume: 20, P: 48-53
De novo design of protein minibinder agonists of TLR3

This study reports the computational design of miniprotein binders of the pattern recognition receptor TLR3. When oligomerized, the miniprotein binders induce TLR3 signaling in cells, suggesting they may be useful components of vaccines or treatments for infectious disease or cancer.

Chloe S. Adams
Hyojin Kim
Neil P. King
ResearchOpen Access31 Jan 2025
Nature Communications

Volume: 16, P: 1-11
Blood Cell Polyamines in Children with Short Stature in Reference to Growth Hormone Activity

S Leisti
J Perheentupa
M A Siimes
Research01 Apr 1980
Pediatric Research

Volume: 14, P: 339-341
Androgen receptors in a Syrian hamster ductus deferens tumour cell line

JAMES S. NORRIS
JACK GORSKI
PETER O. KOHLER
Research29 Mar 1974
Nature

Volume: 248, P: 422-424
Selection of exaggerated male traits by female aesthetic senses

Magnus Enquist
Anthony Arak
Research04 Feb 1993
Nature

Volume: 361, P: 446-448
Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer

The genetic factors that predispose individuals to familial colorectal cancer are poorly understood. In this study, the authors use whole exome sequencing of 1,006 patients and 1,609 healthy controls and show it is unlikely that further major high-penetrance susceptibility genes exist.

Daniel Chubb
Peter Broderick
Richard S. Houlston
ResearchOpen Access22 Jun 2016
Nature Communications

Volume: 7, P: 1-7
Systemic and Neuropathologic Effects of E. coli Endotoxin in Neonatal Dogs

Richard S K Young
Susan K Yagel
Javad Towfighi
Research01 May 1983
Pediatric Research

Volume: 17, P: 349-353
Effects of Prenatal Terbutaline Exposure on Cellular Development in Lung and Liver of Neonatal Rat: Ornithine Decarboxylase Activity and Macromolecules

E M Kudlacz
H A Navarro
T A Slotkin
Research01 Jun 1989
Pediatric Research

Volume: 25, P: 617-622
Effects of Inspiratory Resistive Loading on Chest Wall Motion and Ventilation: Differences between Preterm and Full-Term Infants

Kiran S Deoras
Jay S Greenspan
Julian L Allen
Research01 Nov 1992
Pediatric Research

Volume: 32, P: 589-594
Elucidating the polycyclic aromatic hydrocarbons involved in soot inception

Polycyclic aromatic hydrocarbons (PAHs) are the main precursors to soot particles in combustion systems, but the transition from gas-phase species to organic soot clusters is still not fully understood. Here, the authors study infant soot particles with mass spectrometry and kinetic Monte Carlo simulations and identify peri-condensed PAHs to be the most thermodynamically stable species.

Can Shao
Qi Wang
S. Mani Sarathy
ResearchOpen Access16 Oct 2023
Communications Chemistry

Volume: 6, P: 1-8
Intestinal γ/δ Receptor-Bearing T Lymphocytes in Celiac Disease and Inflammatory Bowel Diseases in Children. Constant Increase in Celiac Disease

E Savilahti
A Arato
M Verkasalo
Research01 Dec 1990
Pediatric Research

Volume: 28, P: 579-581
The Distribution of T and B Lymphocyte Populations and MHC Class II Expression in Human Fetal and Postnatal Intestine

Gary J Russell
Atul K Bhan
Harland S Winter
Research01 Mar 1990
Pediatric Research

Volume: 27, P: 239-244
Synthetic DNA spike-ins (SDSIs) enable sample tracking and detection of inter-sample contamination in SARS-CoV-2 sequencing workflows

An amplicon-based sequencing protocol that includes synthetic DNA spike-ins improves the quality and efficiency of SARS-CoV-2 high-throughput sequencing and detects common errors in genomic data.

Kim A. Lagerborg
Erica Normandin
Katherine J. Siddle
Research14 Dec 2021
Nature Microbiology

Volume: 7, P: 108-119
TCF12 is mutated in anaplastic oligodendroglioma

Anaplastic oligodendrogliomas are rare and incurable primary brain tumours with few treatment options. Here Labrecheet al. perform whole-exome sequencing and identify recurring mutations in transcription factor TCF12, which are associated with aggressive tumours.

Karim Labreche
Iva Simeonova
Michel Wager
ResearchOpen Access12 Jun 2015
Nature Communications

Volume: 6, P: 1-9
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

Richard Houlston and colleagues report a new risk locus for childhood acute lymphoblastic leukemia. The associated variant is located in the CDKN2A gene at chromosome 9p21.

Amy L Sherborne
Fay J Hosking
Richard S Houlston
Research09 May 2010
Nature Genetics

Volume: 42, P: 492-494
Erratum: Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Claire Palles
Jean-Baptiste Cazier
Ian Tomlinson
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 713
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

Richard Houlston, Kari Hemminki and colleagues report a meta-analysis of genome-wide association studies of multiple myeloma and identify a variant in the CCDN1 gene that influences risk for developing a specific tumor karyotype with the t(11;14)(q13;q32) translocation.

Niels Weinhold
David C Johnson
Kari Hemminki
Research17 Mar 2013
Nature Genetics

Volume: 45, P: 522-525
Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex

Polycystic kidney disease family proteins form heteromeric complexes with transient receptor potential channel subunits of the TRPP subfamily. Yu and colleagues find that the polycystic kidney disease protein, PKD1L3, is an ion channel pore-forming subunit in the acid-sensing PKD1L3/TRPP3 complex.

Yong Yu
Maximilian H. Ulbrich
Jian Yang
Research04 Dec 2012
Nature Communications

Volume: 3, P: 1-11
Common variation at 10p12.31 near MLLT10 influences meningioma risk

Richard Houlston, Matthias Simon and colleagues report that common variation at 10p12.31 influences meningioma susceptibility. The risk variants are located upstream of MLLT10, which encodes an activator of Wnt-dependent transcription.

Sara E Dobbins
Peter Broderick
Richard S Houlston
Research31 Jul 2011
Nature Genetics

Volume: 43, P: 825-827
The psychophysiological mechanisms of real-world time experience

Ruth S. Ogden
Chelsea Dobbins
Stephen Fairclough
ResearchOpen Access28 Jul 2022
Scientific Reports

Volume: 12, P: 1-10
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants

A microfluidic CRISPR-based platform enables multiplexed and high-throughput identification of a wide range of respiratory viruses, including the ability to identify specific SARS-CoV-2 variants such as Delta and Omicron.

Nicole L. Welch
Meilin Zhu
Cameron Myhrvold
ResearchOpen Access07 Feb 2022
Nature Medicine

Volume: 28, P: 1083-1094
Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death

In a new study including 200 families who experienced perinatal death, adding genomic analyses to standard autopsies improved the identification of underlying pathogenic causes and informed genetic counseling.

Alicia B. Byrne
Peer Arts
Hamish S. Scott
ResearchOpen Access19 Jan 2023
Nature Medicine

Volume: 29, P: 180-189
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Ian Tomlinson and colleagues report the identification of germline variants in POLE and POLD1 that are susceptibility alleles for colorectal cancer. POLE and POLD1 encode DNA polymerases that function in DNA replication.

Claire Palles
Jean-Baptiste Cazier
Ian Tomlinson
Research23 Dec 2012
Nature Genetics

Volume: 45, P: 136-144
Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer

Promoter capture Hi-C in colorectal cancer cells integrated with cancer genome and expression data identifies a noncoding, cis-regulatory element that is recurrently mutated in cancer, affecting ETV1 expression, cell viability and patient survival.

Giulia Orlando
Philip J. Law
Richard S. Houlston
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1375-1380
Reflex Modification Audiometry: Assessment of Acoustic Sensory Processing in the Term Neonate

Endla K Anday
Michelle E Cohen
Howard S Hoffman
Research01 Apr 1988
Pediatric Research

Volume: 23, P: 357-363
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

Richard Houlston and colleagues report results of a genome-wide association study of Hodgkin's lymphoma. They identify three new susceptibility loci at 2p16 (REL), 8q24 and 10p14 (GATA3) and confirm a strong role for the HLA region in disease etiology.

Victor Enciso-Mora
Peter Broderick
Richard S Houlston
Research31 Oct 2010
Nature Genetics

Volume: 42, P: 1126-1130
Correspondence: SEMA4A variation and risk of colorectal cancer

Ben Kinnersley
Daniel Chubb
Richard S. Houlston
CorrespondenceOpen Access10 Mar 2016
Nature Communications

Volume: 7, P: 1-3
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

Ian Tomlinson, Richard Houlston, Malcolm Dunlop and colleagues report results of a large genome-wide association study of colorectal cancer. They identify four new risk loci and suggest that many more loci of similar effect size are likely to exist.

Richard S Houlston
Jeremy Cheadle
Ian P M Tomlinson
Research24 Oct 2010
Nature Genetics

Volume: 42, P: 973-977
Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

Richard Houlston and colleagues identify common variants at four loci associated with risk of chronic lymphocytic leukemia, including a coding variant in FARP2 on 2q37.3 and a noncoding variant in the region upstream of MYC on 8q24.21.

Dalemari Crowther-Swanepoel
Peter Broderick
Richard S Houlston
Research10 Jan 2010
Nature Genetics

Volume: 42, P: 132-136
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

Richard Houlston and colleagues report a genome-wide association study of multiple myeloma and identify four loci associated with susceptibility to this malignancy.

Daniel Chubb
Niels Weinhold
Hartmut Goldschmidt
Research18 Aug 2013
Nature Genetics

Volume: 45, P: 1221-1225
Genome-wide association study identifies five susceptibility loci for glioma

Richard Houlston, Melissa Bondy and colleagues identify variants at five loci associated with glioma susceptibility, providing insights into the etiology of this primary brain tumor. The risk loci include common variants near TERT, CDKN2A-CDKN2B and RTEL1.

Sanjay Shete
Fay J Hosking
Richard S Houlston
Research05 Jul 2009
Nature Genetics

Volume: 41, P: 899-904
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk

Richard Houlston, Gareth Morgan, Kari Hemminki and colleagues report the results of a genome-wide association study of multiple myeloma. They identify two regions influencing susceptibility to this hematological malignancy.

Peter Broderick
Daniel Chubb
Richard S Houlston
Research27 Nov 2011
Nature Genetics

Volume: 44, P: 58-61
Increased Respiratory Drive and Limited Adaptation to Loaded Breathing in Bronchopulmonary Dysplasia

Jay S Greenspan
Marla R Wolfson
Thomas H Shaffer
Research01 Sept 1992
Pediatric Research

Volume: 32, P: 356-359
An α₁-Receptor Blocker Reduces Plasma Leptin Levels in Hypertensive Patients with Obesity and Hyperleptinemia

Shunichi Ihara
Ken Shimamoto
Masatoshi Kawana
Research01 Oct 2006
Hypertension Research

Volume: 29, P: 805-811
Molecular analysis of Japanese patients with steroid 21-hydroxylase deficiency

A. Asanuma
T. Ohura
Kazuie Iinuma
Research01 Aug 1999
Journal of Human Genetics

Volume: 44, P: 312-317
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Author Correction: Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death

Alicia B. Byrne
Peer Arts
Hamish S. Scott
Amendments and Corrections10 Jul 2023
Nature Medicine

Volume: 30, P: 302
Silicic acid limitation drives bloom termination and potential carbon sequestration in an Arctic bloom

Jeffrey W. Krause
Isabelle K. Schulz
Susana Agustí
ResearchOpen Access31 May 2019
Scientific Reports

Volume: 9, P: 1-11
Polymorphisms of the tumor necrosis factor alpha locus among autoimmune disease susceptible and resistant inbred rat strains

T Furuya
B Joe
EF Remmers
Research26 Jul 2001
Genes & Immunity

Volume: 2, P: 229-232
Mutational processes contributing to the development of multiple myeloma

Phuc H. Hoang
Alex J. Cornish
Richard S. Houlston
ResearchOpen Access06 Aug 2019
Blood Cancer Journal

Volume: 9, P: 1-11
Whole-genome sequencing of multiple myeloma reveals oncogenic pathways are targeted somatically through multiple mechanisms

Phuc H. Hoang
Sara E. Dobbins
Richard S. Houlston
ResearchOpen Access09 Apr 2018
Leukemia

Volume: 32, P: 2459-2470
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer

Nada A. Al-Tassan
Nicola Whiffin
Richard S. Houlston
ResearchOpen Access20 May 2015
Scientific Reports

Volume: 5, P: 1-11
Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Maria N. Timofeeva
Ben Kinnersley
Richard S. Houlston
ResearchOpen Access10 Nov 2015
Scientific Reports

Volume: 5, P: 1-10
Maternal smoking during pregnancy and offspring overweight: is there a dose–response relationship? An individual patient data meta-analysis

Lucia Albers
Christina Sobotzki
Rüdiger von Kries
Reviews28 Feb 2018
International Journal of Obesity

Volume: 42, P: 1249-1264
Exophthalmos and corneal edema in a young ferret

Amy J. Funk
Tiffani D. Rogers
Kelli Boyd
Comments & Opinion01 Oct 2006
Lab Animal

Volume: 35, P: 19
Brain stimulation in zero gravity: transcranial magnetic stimulation (TMS) motor threshold decreases during zero gravity induced by parabolic flight

Bashar W. Badran
Kevin A. Caulfield
Donna R. Roberts
ResearchOpen Access21 Sept 2020
npj Microgravity

Volume: 6, P: 1-7
Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer

Nada A. Al-Tassan
Nicola Whiffin
Richard S. Houlston
Amendments and Corrections03 Aug 2015
Scientific Reports

Volume: 5, P: 1

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