In some men, increased age is associated with a reduction in testosterone, with a range of sexual, physical and psychological symptoms. Although this syndrome is referred to by many names, late-onset hypogonadism (LOH) is the most scientifically accurate. In this Review, Huhtaniemi and Forti summarize the pathophysiology, diagnostic criteria and treatment options for LOH, and discuss the controversies that surround the LOH diagnosis and the use of androgen replacement therapy.
- Ilpo Huhtaniemi
- Gianni Forti
