Targeting proinflammatory/oxidative enzymes is a promising approach to treat inflammatory diseases. Here the authors present a dual-specificity inhibitor for the simultaneous targeting of Vascular Adhesion Protein-1 and Myeloperoxidase, two cooperative but functionally independent enzymes, and report potent anti-inflammatory effects of the dual inhibitor in multiple animal models of inflammatory disease.
- Elias Glaros
- Jonathan Foot
- Shane R. Thomas
