The ageing of haematopoietic stem cells (HSCs) might underlie immune system-associated pathologies such as autoimmunity and leukaemias in the elderly. In this Review, the authors summarize the cell-intrinsic and cell-extrinsic mechanisms that have been associated with HSC ageing and discuss how these mechanisms could be targeted to rejuvenate HSCs.
- Hartmut Geiger
- Gerald de Haan
- M. Carolina Florian