Nature Search

Control of photoreceptor axon target choice by transcriptional repression of Runt

Joshua S. Kaminker
Jude Canon
Utpal Banerjee
Research15 Jul 2002
Nature Neuroscience

Volume: 5, P: 746-750
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism

Phillip Dicker
Enrique Rozengurt
Research16 Oct 1980
Nature

Volume: 287, P: 607-612
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Is there evidence for universal rotation?

E. S. PHINNEY
R. L. WEBSTER
Research24 Feb 1983
Nature

Volume: 301, P: 735-736
Elastic distortion of myosin heads and repriming of the working stroke in muscle

Vincenzo Lombard
Gabriella Piazzesi
Malcolm Irving
Research06 Apr 1995
Nature

Volume: 374, P: 553-555
Myeloid colony-forming cells express human B lymphocyte antigens

JOSEPH KAPLAN
SUSUMU INOUE
MARK J. OTTENBREIT
Research02 Feb 1978
Nature

Volume: 271, P: 458-459
Orphan receptor GPR37L1 remains unliganded

Tony Ngo
Brendan P. Wilkins
Nicola J. Smith
Research01 Mar 2021
Nature Chemical Biology

Volume: 17, P: 383-386
Pt-induced atomic-level tailoring towards paracrystalline high-entropy alloy

Paracrystalline state is still challenging to reach in alloy systems in a controlled manner. Here, the authors present an atomic-level tailoring route to create paracrystalline Zr-Nb-Hf-Ta-Mo high-entropy alloy through local amorphization induced by atomic-level Pt with negative mixing enthalpy.

Xingjia He
Yu Zhang
Weitao Zheng
ResearchOpen Access11 Feb 2023
Nature Communications

Volume: 14, P: 1-13
Isolation of Radioactive Bismuth from Metallic Lead and its Compounds

J. R. W. KERR
D. I. COOMBER
D. T. LEWIS
Research11 Nov 1961
Nature

Volume: 192, P: 547-548
Allosteric modulation and biased signalling at free fatty acid receptor 2

Structural, pharmacological and computational studies reveal how different classes of positive allosteric modulators bind to distinct allosteric sites and use noncanonical mechanisms to activate the free-fatty acid receptor FFA2.

Xuan Zhang
Abdul-Akim Guseinov
Cheng Zhang
Research18 Jun 2025
Nature

Volume: 643, P: 1428-1438
The proper motion of Geminga's optical counterpart

G. F. Bignami
P. A. Caraveo
S. Mereghetti
Research25 Feb 1993
Nature

Volume: 361, P: 704-706
Modern light microscopy

Michael Spencer
News & Views02 Jul 1981
Nature

Volume: 292, P: 9-10
Spin-down episode of the X-ray pulsar Vela X-1

F. Nagase
S. Hayakawa
K. Yamashita
Research16 Apr 1981
Nature

Volume: 290, P: 572-573
Experimental investigation of geologically produced antineutrinos with KamLAND

T. Araki
S. Enomoto
F. Piquemal
Research28 Jul 2005
Nature

Volume: 436, P: 499-503
Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa

Authors analyzed a large dihydroartemisinin–piperaquine (DHA-PPQ) repetitive treatment efficacy trial including a 2-year follow-up period, monitoring the evolution of the protective effect of this antimalarial over time.

Leyre Pernaute-Lau
Mario Recker
José Pedro Gil
ResearchOpen Access18 Mar 2025
Nature Communications

Volume: 16, P: 1-7
Clinical application of a lung cancer organoid (tumoroid) culture system

Etsuko Yokota
Miki Iwai
Tomoki Yamatsuji
ResearchOpen Access12 Apr 2021
npj Precision Oncology

Volume: 5, P: 1-12
Structural insights into serpin—protease complexes reveal the inhibitory mechanism of serpins

Analysis of native serpin–protease complexes indicate that inhibition by serpins involves reactive centre cleavage and partial loop insertion, whereby the covalently linked protease migrates from the position of the initial attack to a position on the surface of the inhibitor β-sheet A to form a virtually irreversible complex.

Malgorzata Wilczynska
Ming Fa
Tor Ny
Correspondence01 May 1997
Nature Structural Biology

Volume: 4, P: 354-357
Reaching the pinnacle of high-capacity optical transmission using a standard cladding diameter coupled-core multi-core fiber

Space division multiplexing offers increased capacity over current fiber networks. Here, the authors demonstrate petabit/s transmission in a standard-sized 19-core multi-core fiber, while minimizing the required digital signal processing complexity.

Menno van den Hout
Ruben S. Luís
Georg Rademacher
ResearchOpen Access23 Apr 2025
Nature Communications

Volume: 16, P: 1-8
Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer

Yew S. Ho
Lora Swenson
Zygmunt S. Derewenda
Research02 Jan 1997
Nature

Volume: 385, P: 89-93
Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation

Robbins and colleagues show that cigarette smoke-induced endothelial dysfunction enables atherosclerotic plaque macrophages to drive abdominal aortic aneurysm formation in a mouse model of atherosclerosis.

Danya Thayaparan
Takuo Emoto
Clinton S. Robbins
Research22 Apr 2025
Nature Immunology

Volume: 26, P: 706-721
Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

Laura Lara-Castor
Meghan O’Hearn
Rubina Hakeem
ResearchOpen Access06 Jan 2025
Nature Medicine

Volume: 31, P: 552-564
Evidence for deep mantle circulation from global tomography

R. D. van der Hilst
S. Widiyantoro
E. R. Engdahl
Research10 Apr 1997
Nature

Volume: 386, P: 578-584
The evolution of flowers with deep corolla tubes

L. Anders Nilsson
Research14 Jul 1988
Nature

Volume: 334, P: 147-149
Regulation of PLC-mediated signalling in vivo by CDP-diacylglycerol synthase

Louisa Wu
Barbara Niemeyer
Charles S. Zuker
Research19 Jan 1995
Nature

Volume: 373, P: 216-222
Identification of a thymic inhibitor (‘chalone’) of lymphocyte transformation as a spermine complex

J. C. ALLEN
C. J. SMITH
J. M. GAUGAS
Research16 Jun 1977
Nature

Volume: 267, P: 623-625
Control of topology and mode of assembly of a polytopic membrane protein by positively charged residues

Gunnar vonHeijne
Research05 Oct 1989
Nature

Volume: 341, P: 456-458
Effect of transplantation of pancreas on development of hypothalamic obesity

SHUJI INOUE
GEORGE A. BRAY
YOKO S. MULLEN
Research21 Apr 1977
Nature

Volume: 266, P: 742-744
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

Hiroshi Inoue
Yukio Tanizawa
M. Alan Permutt
Research01 Oct 1998
Nature Genetics

Volume: 20, P: 143-148
The reeler gene encodes a protein with an EGF–like motif expressed by pioneer neurons

S. Hirotsune
T. Takahara
Y. Hayashizaki
Research01 May 1995
Nature Genetics

Volume: 10, P: 77-83
Reconstituting the complete biosynthesis of D-lysergic acid in yeast

The ergot alkaloids are a class of natural products known for their pharmacologically privileged molecular structure that are used in the treatment of neurological ailments. Here the authors report on the production of the ergot (fungus)-derived therapeutic precursor, D-lysergic acid (DLA), in baker’s yeast.

Garrett Wong
Li Rong Lim
Wen Shan Yew
ResearchOpen Access07 Feb 2022
Nature Communications

Volume: 13, P: 1-10
The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

Rommel G. Tirona
Wooin Lee
Richard B. Kim
Research06 Jan 2003
Nature Medicine

Volume: 9, P: 220-224
Massively parallel characterization of transcriptional regulatory elements

Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.

Vikram Agarwal
Fumitaka Inoue
Nadav Ahituv
ResearchOpen Access15 Jan 2025
Nature

Volume: 639, P: 411-420
Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis

Autoimmune pulmonary alveolar proteinosis (aPAP) is a complex lung disease caused by abnormal surfactant homeostasis. Here, the authors carry out a genome-wide association study of aPAP in a Japanese cohort, finding variants in the MHC and suggesting predisposition to abnormal antibody production.

Saori Sakaue
Etsuro Yamaguchi
Yukinori Okada
ResearchOpen Access15 Feb 2021
Nature Communications

Volume: 12, P: 1-6
On-shelf circulation of warm water toward the Totten Ice Shelf in East Antarctica

The Totten Glacier in East Antarctica is grounded below sea level and vulnerable to ocean forcing. Observations and simulations demonstrate warm water access from offshore to the glacier, facilitated by deep topography off the Sabrina Coast.

Daisuke Hirano
Takeshi Tamura
Shigeru Aoki
ResearchOpen Access17 Aug 2023
Nature Communications

Volume: 14, P: 1-15
Discovery of an unusual hard X-ray source in the region of supernova 1987A

T. Dotani
K. Hayashida
D. H. Reading
Research19 Nov 1987
Nature

Volume: 330, P: 230-231
A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAF^V600E colorectal tumors

Coppé and colleagues define a resistance mechanism to combination BRAF- and EGFR-targeted therapy in BRAF^V600E colorectal cancers that could be overcome in vitro and in vivo by repurposing COX2 inhibitors.

Ana Ruiz-Saenz
Chloe E. Atreya
Jean-Philippe Coppé
ResearchOpen Access09 Feb 2023
Nature Cancer

Volume: 4, P: 240-256
Pancytopenia in Propionic Acidemia: Hematologic Evaluation and Studies of Hematopoiesis in Vitro

Linda C Stork
Daniel R Ambruso
Edward R B McCabe
Research01 Aug 1986
Pediatric Research

Volume: 20, P: 783-788
No IR burst from the X-ray rapid burster MXB1730–335

S. Sato
K. Kawara
J. Jugaku
Research14 Aug 1980
Nature

Volume: 286, P: 688-689
Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103

GPR103, a GPCR activated by pyroglutamylated RF-amide peptide QRFP, has various physiological functions, such as energy metabolism and appetite regulation. Here, the authors determined the cryoEM structure of the QRFP26- GPR103-Gq complex, revealing its peptide recognition mechanism.

Aika Iwama
Ryoji Kise
Osamu Nureki
ResearchOpen Access19 Jun 2024
Nature Communications

Volume: 15, P: 1-13
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Anisotropy of Young's modulus of bone

J. Lawrence Katz
Research03 Jan 1980
Nature

Volume: 283, P: 106-107
Deacetylation as a receptor-regulated direct activation switch for pannexin channels

Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that involves HDAC6- mediated lysine deacetylation of PANX1.

Yu-Hsin Chiu
Christopher B. Medina
Douglas A. Bayliss
ResearchOpen Access23 Jul 2021
Nature Communications

Volume: 12, P: 1-14
Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

Kyriakopoulou et al. report that adeno-associated virus-mediated delivery of PKP2 in PKP2^{c.2013delC/WT} induced pluripotent stem cell-derived cardiomyocytes and heterozygous Pkp2^c.1755delA knock-in mice restores cardiomyocyte junctions, enhances cardiac function and mitigates arrhythmogenic substrates leading to arrhythmogenic cardiomyopathy.

Eirini Kyriakopoulou
Danielle Versteeg
Eva van Rooij
ResearchOpen Access07 Dec 2023
Nature Cardiovascular Research

Volume: 2, P: 1262-1276
Cloning and characterization of a gene that regulates cell adhesion

W. E. Pullman
W. F. Bodmer
Research09 Apr 1992
Nature

Volume: 356, P: 529-532
A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density

N. Ota
T. Nakajima
M. Emi
Research01 Apr 2001
Journal of Human Genetics

Volume: 46, P: 267-272
Comparison of radiobiological effective depths in 65-MeV modulated proton beams

JT Tang
T Inoue
K Hatanaka
Research01 Jul 1997
British Journal of Cancer

Volume: 76, P: 220-225
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke

Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and treats MH and heat stroke in various MH mouse models.

Toshiko Yamazawa
Takuya Kobayashi
Takashi Murayama
ResearchOpen Access13 Jul 2021
Nature Communications

Volume: 12, P: 1-14
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Children’s and adolescents’ rising animal-source food intakes in 1990–2018 were impacted by age, region, parental education and urbanicity

An analysis based on data from the Global Dietary Database shows mean animal-sourced food intakes among children and adolescents increased modestly from 1990 to two portions per day in 2018, but remain low in sub-Saharan Africa, India and Bangladesh.

Victoria Miller
Patrick Webb
Rubina Hakeem
ResearchOpen Access20 Apr 2023
Nature Food

Volume: 4, P: 305-319

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