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Showing 51–100 of 206 results

Advanced filters: Author: S Mochizuki Clear advanced filters

Orexin neurons inhibit sleep to promote arousal

Sleep and wakefulness is stabilized by a population of orexin-expressing neurons. In this study, the authors demonstrate how these neurons drive arousal by silencing sleep-promoting neurons in the ventrolateral preoptic nucleus.

Roberto De Luca
Stefano Nardone
Elda Arrigoni
ResearchOpen Access18 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins

Chemical and mechanical cues coordinately regulate angiogenesis. Here, the authors show that blood flow-driven intraluminal pressure regulates wound angiogenesis. Findings indicate that TOCA family of F-BAR proteins act as actin regulators required for endothelial cell migration and sense mechanical cell stretching to regulate wound angiogenesis.

Shinya Yuge
Koichi Nishiyama
Shigetomo Fukuhara
ResearchOpen Access12 May 2022
Nature Communications

Volume: 13, P: 1-25
Immune mechanisms in autoimmune ocular disease

S Lightman
Research01 May 1988
Eye

Volume: 2, P: 260-266
T lymphocyte effector mechanisms in the retina in posterior uveitis

K Barton
S Lightman
Research01 Jan 1994
Eye

Volume: 8, P: 60-65
Functional variants in a TTTG microsatellite on 15q26.1 cause familial nonautoimmune thyroid abnormalities

Noncoding variants in a TTTG microsatellite on 15q26.1 are identified in Japanese patients with childhood and adult-onset thyroid abnormalities. Functional analyses suggest that these variants affect the role of the microsatellite as a potential regulator of thyroid cell growth.

Satoshi Narumi
Keisuke Nagasaki
Tomonobu Hasegawa
ResearchOpen Access07 May 2024
Nature Genetics

Volume: 56, P: 869-876
Decreased Stimulated GM-CSF Production and GM-CSF Gene Expression but Normal Numbers of GM-CSF Receptors in Human Term Newborns Compared with Adults

Mitchell S Cairo
Y U Suen
Leonard Sender
Research01 Oct 1991
Pediatric Research

Volume: 30, P: 362-367
Ontogeny of Hepatic Peroxisomal Uricase Activity in the Mongrel Puppy

Peter F Whitington
F Bruder Stapleton
Sharon R Gross
Research01 Sept 1983
Pediatric Research

Volume: 17, P: 714-716
Glycine Cleavage System in Ketotic Hyperglycinemia: a Reduction of H-Protein Activity

Kiyoshi Hayasaka
Kuniaki Narisawa
Noritake Matsuo
Research01 Jan 1982
Pediatric Research

Volume: 16, P: 5-7
Detection of varicella-zoster virus DNA in ocular samples from patients with uveitis but no cutaneous eruption

P Stavrou
S M Mitchell
P I Murray
Research01 Nov 1994
Eye

Volume: 8, P: 684-687
Influence of minor trauma to the neck on the neurological outcome in patients with ossification of the posterior longitudinal ligament (OPLL) of the cervical spine

S Katoh
T Ikata
K Nakauchi
Research01 Jun 1995
Spinal Cord

Volume: 33, P: 330-333
A Patient with Nonketotic Hyperglycinemia: Biochemical Findings and Therapeutic Approaches

J M F Trijbels
L A H Monnens
E D A M Schretlen
Research01 May 1974
Pediatric Research

Volume: 8, P: 598-605
Nonketotic Hyperglycinemia: Two Patients with Primary Defects of P-Protein and T-Protein, Respectively, in the Glycine Cleavage System

Kiyoshi Hayasaka
Keiya Tada
William L Nyhan
Research01 Dec 1983
Pediatric Research

Volume: 17, P: 967-970
A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo

Naphthyridine-azaquinolone specifically binds slipped-CAG DNA intermediates, induces contractions of expanded repeats and reduces mutant HTT protein aggregates in cell and animal models of Huntington’s disease.

Masayuki Nakamori
Gagan B. Panigrahi
Christopher E. Pearson
Research14 Feb 2020
Nature Genetics

Volume: 52, P: 146-159
Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing

Attaching a syndecan-binding domain to vascular endothelial and platelet-derived growth factor variants enhances their binding to syndecans and triggers tonic signalling for enhanced bone regeneration and wound repair in mice.

Mayumi Mochizuki
Esra Güç
Mikaël M. Martino
Research04 Nov 2019
Nature Biomedical Engineering

Volume: 4, P: 463-475
Observation of electroweak production of two jets and a Z-boson pair

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access09 Feb 2023
Nature Physics

Volume: 19, P: 237-253
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

Mutations in the EZH2 gene are found in myelodysplastic syndrome (MDS) and are often accompanied by mutations in RUNX1. Here, the authors develop a mouse model of MDS and show that EZH2loss enhances the RUNX1-mediated MDS pathology.

Goro Sashida
Hironori Harada
Atsushi Iwama
Research23 Jun 2014
Nature Communications

Volume: 5, P: 1-14
Episodic stress and fluid pressure cycling in subducting oceanic crust during slow slip

Stress cycling in subducting crust before and during slow slip events is due to accumulation and release of fluid pressure, according to analysis of small earthquakes in the Hikurangi subduction zone.

E. Warren-Smith
B. Fry
S. Lebedev
Research20 May 2019
Nature Geoscience

Volume: 12, P: 475-481
Néel-type skyrmion lattice with confined orientation in the polar magnetic semiconductor GaV₄S₈

A Néel-type skyrmion lattice is found to be formed in the lacunar spinel GaV₄S₈—a polar magnetic semiconductor with rhombohedral symmetry and easy axis anisotropy.

I. Kézsmárki
S. Bordács
A. Loidl
Research07 Sept 2015
Nature Materials

Volume: 14, P: 1116-1122
Identification of mutations in the α3(IV) and α4(IV) collagen genes in autosomal recessive Alport syndrome

Toshio Mochizuki
Henny H. Lemmink
Stephen T. Reeders
Research01 Sept 1994
Nature Genetics

Volume: 8, P: 77-82
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

Histamine causes vascular leakage by a direct and yet mechanistically poorly defined effect on endothelium. Here, the authors show that histamine elicits endothelial RhoA/Rock signaling and that inhibition of this pathway preserves the vascular barrier, thereby identifying novel pharmacological targets for histamine-mediated diseases.

Constantinos M. Mikelis
May Simaan
J. Silvio Gutkind
Research10 Apr 2015
Nature Communications

Volume: 6, P: 1-11
Test of the universality of τ and μ lepton couplings in W-boson decays with the ATLAS detector

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access05 Jul 2021
Nature Physics

Volume: 17, P: 813-818
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses

Michael Lazarus
Kyoko Yoshida
Clifford B Saper
Research05 Aug 2007
Nature Neuroscience

Volume: 10, P: 1131-1133
Search for charged-lepton-flavour violation in Z-boson decays with the ATLAS detector

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access01 Jul 2021
Nature Physics

Volume: 17, P: 819-825
North Atlantic climate far more predictable than models imply

Current models are too noisy to predict climate usefully on decadal timescales, but two-stage post-processing of model outputs greatly improves predictions of decadal variations in North Atlantic winter climate.

D. M. Smith
A. A. Scaife
L. Zhang
Research29 Jul 2020
Nature

Volume: 583, P: 796-800
Cloning of inv, a gene that controls left/right asymmetry and kidney development

Toshio Mochizuki
Yukio Saijoh
Takahiko Yokoyama
Research10 Sept 1998
Nature

Volume: 395, P: 177-181
Effects of Hydrophobic Solvents on X-Ray Diffraction Patterns of Regenerated Cellulose Membrane

Kazuishi Sato
Hisaya Mochizuki
Chihiro Yamane
Research15 Jun 2004
Polymer Journal

Volume: 36, P: 478-482
Global assessment of water challenges under uncertainty in water scarcity projections

Designing interventions to address water scarcity under climate change is challenging given the large uncertainties in projected water availability. In this study, changes in the uncertainty range of anticipated water scarcity conditions are identified, and a general decision-making framework to support policy decisions is developed.

P. Greve
T. Kahil
Y. Wada
Research14 Sept 2018
Nature Sustainability

Volume: 1, P: 486-494
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

Ten years after the discovery of the Higgs boson, the ATLAS experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 52-59
Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form

Raj S Mitra
Zhaocheng Zhang
Nisha J D'Silva
Research18 Sept 2003
Oncogene

Volume: 22, P: 6243-6256
Administration-route and gender-independent long-term therapeutic correction of phenylketonuria (PKU) in a mouse model by recombinant adeno-associated virus 8 pseudotyped vector-mediated gene transfer

Z Ding
P Georgiev
B Thöny
Research01 Dec 2005
Gene Therapy

Volume: 13, P: 587-593
Effect of fluctuation of oxygenation on the development of severe retinopathy of prematurity in extremely preterm infants

Yousuke Imanishi
Katsuya Hirata
Kazuko Wada
Research06 Jan 2020
Journal of Perinatology

Volume: 40, P: 515-521
Microscopic ordering of supercooled water on the ice basal face

The melt growth of ice - crystallization from supercooled water - has complex anisotropic kinetics, closely related to the rich variety of snowflake crystals. Here, molecular dynamics simulations shed light on its microscopic mechanism, identifying a layer of ultralow density water at the growth interface.

Kenji Mochizuki
Ken-ichiro Murata
Xuan Zhang
ResearchOpen Access19 May 2023
Communications Materials

Volume: 4, P: 1-10
Futile complete recanalization: patients characteristics and its time course

Takaya Kitano
Kenichi Todo
Takeshi Morimoto
ResearchOpen Access18 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Machine learning for morbid glomerular hypertrophy

Yusuke Ushio
Hiroshi Kataoka
Kosaku Nitta
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-12
Particle-size dependent structural transformation of skyrmion lattice

Skyrmions are topological spin textures and are of great interest due to their impressive stability. Here, by sweeping an applied magnetic field, the authors observe a change in the skyrmion lattice structure, shedding light on the relation between skyrmion size and stability.

R. Takagi
Y. Yamasaki
S. Seki
ResearchOpen Access11 Nov 2020
Nature Communications

Volume: 11, P: 1-7
Imaging magnetic spiral phases, skyrmion clusters, and skyrmion displacements at the surface of bulk Cu₂OSeO₃

Surfaces can significantly influence magnetic order by breaking bulk symmetries, introducing roughness, or hosting defects. Here, a microscopy study of the surface of bulk Cu₂OSeO₃ reveals magnetic textures associated with distinct surface states, such as in-plane magnetic stripes that are absent in the bulk, and demonstrates the local displacement of individual skyrmions by an applied electric field.

Estefani Marchiori
Giulio Romagnoli
Martino Poggio
ResearchOpen Access28 Sept 2024
Communications Materials

Volume: 5, P: 1-12
Regulated selection of germinal-center cells into the memory B cell compartment

T cells provide help to B cells in germinal centers. Kurosaki and colleagues show that B cells of lower affinity receive weaker T cell help. This scenario results in higher expression of the transcriptional repressor Bach2 and promotes the development of memory B cells.

Ryo Shinnakasu
Takeshi Inoue
Tomohiro Kurosaki
Research09 May 2016
Nature Immunology

Volume: 17, P: 861-869
Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins

This paper identifies a gene, kintoun (ktu), which is important for dynein arm formation resulting in the formation of motile cilia. It is conserved from ciliated unicellular organisms to higher mammals. Mutations in the homologous gene of two human primary ciliary dyskinesia families are also identified.

Heymut Omran
Daisuke Kobayashi
Hiroyuki Takeda
Research01 Dec 2008
Nature

Volume: 456, P: 611-616
Blockage of Akt activation suppresses cadmium-induced renal tubular cellular damages through aggrephagy in HK-2 cells

Kota Fujiki
K. Tanabe
M. Matsuoka
ResearchOpen Access24 Jun 2024
Scientific Reports

Volume: 14, P: 1-14
Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish

Following spinal injury in zebrafish, non-neural cells establish an extracellular matrix to promote axon re-growth but how this is regulated is unclear. Here, the authors show that Wnt/β-catenin signaling in fibroblast-like cells at a lesion activates axon re-growth via deposition of Collagen XII.

Daniel Wehner
Themistoklis M. Tsarouchas
Catherina G. Becker
ResearchOpen Access25 Jul 2017
Nature Communications

Volume: 8, P: 1-17
Dispersion of metallic/ceramic matrix nanocomposite material through porous surfaces in magnetized hybrid nanofluids flow with shape and size effects

M. Zubair Akbar Qureshi
S. Bilal
Yong-Min Li
ResearchOpen Access10 Jun 2021
Scientific Reports

Volume: 11, P: 1-19
Impact of kidney function and kidney volume on intracranial aneurysms in patients with autosomal dominant polycystic kidney disease

Hiroshi Kataoka
Hiroyuki Akagawa
Toshio Mochizuki
ResearchOpen Access27 Oct 2022
Scientific Reports

Volume: 12, P: 1-9
Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma

Anaïs Prouteau
Jérôme Alexandre Denis
Benoît Hédan
ResearchOpen Access13 Jan 2021
Scientific Reports

Volume: 11, P: 1-12
A one-base deletion (183delC) and a missense mutation (D276H) in the T-protein gene from a Japanese family with nonketotic hyperglycinemia

S. Kure
Toshikatsu Shinka
Kuniaki Narisawa
Research01 Jun 1998
Journal of Human Genetics

Volume: 43, P: 135-137
Acute Neonatal Nonketotic Hyperglycinemia: Normal Propionate and Methylmalonate Metabolism

E Regula Baumgartner
Claude Bachmann
Hugo Wick
Research01 Jul 1975
Pediatric Research

Volume: 9, P: 559-564
Ab initio molecular dynamics of liquid water using embedded-fragment second-order many-body perturbation theory towards its accurate property prediction

Soohaeng Yoo Willow
Michael A. Salim
So Hirata
ResearchOpen Access24 Sept 2015
Scientific Reports

Volume: 5, P: 1-14
Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line

P S Mackie
J L Fisher
P F M Choong
ResearchOpen Access03 Apr 2001
British Journal of Cancer

Volume: 84, P: 951-958
NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression

D Komatsu
M Kato
T Kamata
Research05 May 2008
Oncogene

Volume: 27, P: 4724-4732
2D NMR Analysis of Acrylonitrile/2-Methoxyethyl Acrylate Copolymers Synthesized by Atom Transfer Radical Polymerization

A S Brar
Tripta Saini
Reviews30 Aug 2006
Polymer Journal

Volume: 38, P: 1023-1034

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