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Showing 1–50 of 74 results

Advanced filters: Author: S Perreault Clear advanced filters

Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance

Melissa L Perreault
Ahmed Hasbi
Susan R George
Reviews18 Jun 2013
Neuropsychopharmacology

Volume: 39, P: 156-168
Evidence for heterogeneity in heterochromatin of Drosophila melanogaster

S. PIMPINELLI
M. GATTI
A. DE MARCO
Research24 Jul 1975
Nature

Volume: 256, P: 335-337
Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases

Paloma Jordà
Yiwei Lai
Rafik Tadros
ResearchOpen Access29 Sept 2025
npj Genomic Medicine

Volume: 10, P: 1-22
Magnetic energy conversion, magnetospheric substorms and solar flares

S.-I. Akasofu
Research20 Mar 1980
Nature

Volume: 284, P: 248-249
North–south component of the interplanetary magnetic field and large scale auroral dynamics

S.-I. AKASOFU
Research17 Jul 1975
Nature

Volume: 256, P: 191-192
Nitric oxide: a new player in the modulation of energy metabolism

S Kapur
F Picard
A Marette
Research01 Nov 2000
International Journal of Obesity

Volume: 24, P: S36-S40
Discovery of the widespread site-specific single-stranded nuclease family Ssn

Site-specific endonucleases that exclusively cut single-stranded DNA have hitherto never been described and constitute a barrier to the development of ssDNA-based technologies. Here the authors identify and characterize a family of such enzymes that could be the basis of innovative molecular tools.

Martin Chenal
Alex Rivera-Millot
Frédéric J. Veyrier
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-15
An international study presenting a federated learning AI platform for pediatric brain tumors

Federated learning (FL) has emerged as a potential solution to train machine learning models in multiple clinical datasets while preserving patient privacy. Here, the authors develop an MRI-based FL platform for pediatric posterior fossa brain tumors—FL-PedBrain—and evaluate it on a diverse multi-center cohort.

Edward H. Lee
Michelle Han
Kristen W. Yeom
ResearchOpen Access02 Sept 2024
Nature Communications

Volume: 15, P: 1-11
Ionic interactions and the global conformations of the hammerhead ribozyme

Gurminder S. Bassi
Niels-Erik Møllegaard
David M.J. Lilley
Research01 Jan 1995
Nature Structural Biology

Volume: 2, P: 45-55
Normal glucose levels should be the goal

Type 2 diabetes mellitus (T2DM) is a major public health problem. However, few clinicians screen routinely to detect this problem early or manage hyperglycaemia aggressively if it is found. As even transient normalization of glucose levels in prediabetes reduces the risk of developing T2DM, these practices should change.

Lawrence S. Phillips
Darin E. Olson
News & Views31 Jul 2012
Nature Reviews Endocrinology

Volume: 8, P: 510-512
Metal ion catalysis in the Tetrahymena ribozyme reaction

Joseph A. Piccirilli
Joseph S. Vyle
Thomas R. Cech
Research07 Jan 1993
Nature

Volume: 361, P: 85-88
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial

Lindsay B. Kilburn
Dong-Anh Khuong-Quang
Karsten Nysom
Amendments and CorrectionsOpen Access16 Apr 2025
Nature Medicine

Volume: 31, P: 2454
Altered glucose and lipid homeostasis in liver and adipose tissue pre-dispose inducible NOS knockout mice to insulin resistance

Babu Nageswararao Kanuri
Jitendra S. Kanshana
Madhu Dikshit
ResearchOpen Access20 Jan 2017
Scientific Reports

Volume: 7, P: 1-14
The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial

In a phase 2 trial, the oral type II RAF inhibitor tovorafenib exhibited an overall response rate of 67% in patients with BRAF-altered relapsed/refractory pediatric low-grade glioma.

Lindsay B. Kilburn
Dong-Anh Khuong-Quang
Karsten Nysom
ResearchOpen Access17 Nov 2023
Nature Medicine

Volume: 30, P: 207-217
A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo

Olweus and colleagues identify a T cell receptor reactive against the recurrent D835Y driver mutation in FLT3 in acute myeloid leukemia and show that engineered T cells against this neoantigen provide efficient immunotherapy.

Eirini Giannakopoulou
Madeleine Lehander
Johanna Olweus
ResearchOpen Access02 Oct 2023
Nature Cancer

Volume: 4, P: 1474-1490
Earth's air pressure 2.7 billion years ago constrained to less than half of modern levels

The composition of the Earth’s early atmosphere is uncertain. The morphology of vesicles in basalts suggests that the air pressure 2.7 billion years ago was less than half of modern levels.

Sanjoy M. Som
Roger Buick
David C. Catling
Research09 May 2016
Nature Geoscience

Volume: 9, P: 448-451
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas

Comprehensive genomic profiling of human H3K27M mutant diffuse midline gliomas, combining single-cell RNA sequencing and ATAC sequencing with bulk ChIP sequencing and other data, proposes distinct oligodendrocyte populations as potential cells of origin.

Selin Jessa
Abdulshakour Mohammadnia
Claudia L. Kleinman
Research05 Dec 2022
Nature Genetics

Volume: 54, P: 1865-1880
A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer

Super-enhancers and their associated transcription factor networks have been shown to influence ovarian cancer biology. Here, based on an integrated set of genomic and epigenomic datasets, the authors identify clinically relevant super-enhancers amplified in ovarian cancer patients and functionally validate their activity.

Michael R. Kelly
Kamila Wisniewska
Hector L. Franco
ResearchOpen Access22 Jul 2022
Nature Communications

Volume: 13, P: 1-22
Broad-scale lake expansion and flooding inundates essential wood bison habitat

Climate change can affect lake water level and nearby landscape. Korosi and colleagues show recent expansion of shallow lakes in the Canadian Northwest Territories is flooding critical habitat for the wood bison, and demonstrate the trickle-down effect of climate change on ecosystem functioning.

Jennifer B. Korosi
Joshua R. Thienpont
Jules M. Blais
ResearchOpen Access23 Feb 2017
Nature Communications

Volume: 8, P: 1-8
Endothelin-A Receptor Blockade in Porcine Pulmonary Hypertension

Namasivayam Ambalavanan
Joseph B Philips
Yiu-Fai Chen
Research01 Dec 2002
Pediatric Research

Volume: 52, P: 913-921
Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate

The human gut microbiome has a substantial impact on human health. Here, the authors find that prominent human gut microbes express functionally distinct surface endo-β-N-acetylglucosaminidases encoded by different polysaccharide utilization loci to optimally metabolize the same oligomannose N-glycan substrate in the gastrointestinal tract.

Diego E. Sastre
Nazneen Sultana
Eric J. Sundberg
ResearchOpen Access15 Jun 2024
Nature Communications

Volume: 15, P: 1-17
Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor signalling - which could be targeted with MEK/EGFR inhibitors.

Dustin J. Flanagan
Raheleh Amirkhah
Owen J. Sansom
ResearchOpen Access07 Dec 2022
Nature Communications

Volume: 13, P: 1-18
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations

Shlien and colleagues report on 300 patients from the SickKids Cancer Sequencing program and identify clinically actionable variants in 56% of the patients by profiling somatic and germline data at multiple clinical time points.

Anita Villani
Scott Davidson
Adam Shlien
ResearchOpen Access30 Dec 2022
Nature Cancer

Volume: 4, P: 203-221
Resource nationalism: the intersection of politics and economics

Deyi Xu
Shiquan Dou
Jinhua Cheng
ResearchOpen Access25 Oct 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-15
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial

Lindsay B. Kilburn
Dong-Anh Khuong-Quang
Karsten Nysom
Amendments and CorrectionsOpen Access11 Mar 2024
Nature Medicine

Volume: 30, P: 1500
Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and antiproliferative effects of prolonged pharmacological mTOR inhibition.

Yoshinori Tsukumo
Tommy Alain
Nahum Sonenberg
ResearchOpen Access20 Jun 2016
Nature Communications

Volume: 7, P: 1-13
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection

MHC class I presentation of viral peptides aids CD8⁺ T cell recognition of infected cells. Desjardins and colleagues describe an MHC class I viral peptide presentation pathway that integrates autophagosomes and proteasome-dependent processes.

Luc English
Magali Chemali
Michel Desjardins
Research22 Mar 2009
Nature Immunology

Volume: 10, P: 480-487
Importance of residue 248 in Escherichia coli RNase P RNA mediated cleavage

Guanzhong Mao
Abhishek S. Srivastava
Leif A. Kirsebom
ResearchOpen Access29 Aug 2023
Scientific Reports

Volume: 13, P: 1-21
Stroke prevention strategies in high-risk patients with atrial fibrillation

Effective stroke prevention with oral anticoagulation is a cornerstone of the management of patients with atrial fibrillation. Caution is required in patients with atrial fibrillation at high risk of stroke and bleeding. In this Review, Lip and colleague discuss strategies for reducing the risk of stroke in patients with atrial fibrillation.

Agnieszka Kotalczyk
Michał Mazurek
Gregory Y. H. Lip
Reviews27 Oct 2020
Nature Reviews Cardiology

Volume: 18, P: 276-290
Kinetics of chimerism during the early post-transplant period in pediatric patients with malignant and non-malignant hematologic disorders: implications for timely detection of engraftment, graft failure and rejection

J Dubovsky
H Daxberger
T Lion
Research02 Dec 1999
Leukemia

Volume: 13, P: 2060-2069
LIPID CLEARING IN PREMATURE INFANTS. RESPONSE TO INCREASING DOSES OF INTRALIPID (IL): I-CIRCULATING LIPOPROTEIN LIPASE(LPL) AND HEPATIC LIPASE(HL)

S Berkow
M L Spear
P Hamosh
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 136
ALTERATION OF ANF SYSTEM IN HYPOXIA-INDUCED PULMONARY HYPERTENSION IN NEWBORN PIGS. † 418

Johanne Baribeau
Jolanta Gutkowska
Thérèse Perreault
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 72
ROLE OF ENDOTHELIN-1 IN HYPOXIA-INDUCED PULMONARY HYPERTENSION IN NEWBORN PIGLETS. • 426

Richard Gosselin
Johanne Baribeau
Thérèse Perreault
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 73
Discrete roles of canonical and non-canonical Wnt signaling in hematopoiesis and lymphopoiesis

F Famili
B A E Naber
F J T Staal
ResearchOpen Access19 Nov 2015
Cell Death & Disease

Volume: 6, P: e1981
Self-biting with multiple finger amputations following spinal cord injury

Patricia A Dahlin
Nancy E Van Buskirk
John George
Research01 Oct 1985
Spinal Cord

Volume: 23, P: 306-318
Striatal Neurons Expressing D₁ and D₂ Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice

D. Gagnon
S. Petryszyn
M. Parent
ResearchOpen Access27 Jan 2017
Scientific Reports

Volume: 7, P: 1-16
Novel therapies with precision mechanisms for type 2 diabetes mellitus

More than 7,000 clinical trials are currently ongoing involving new drugs for type 2 diabetes mellitus (T2DM). This Review summarizes the novel drugs in development for T2DM that improve insulin sensitivity, stimulate insulin secretion or the incretin axis, or suppress hepatic glucose production.

Leigh Perreault
Jay S. Skyler
Julio Rosenstock
Reviews04 May 2021
Nature Reviews Endocrinology

Volume: 17, P: 364-377
Cas3 of type I-Fa CRISPR-Cas system upregulates bacterial biofilm formation and virulence in Acinetobacter baumannii

Deletion of cas3(type I-Fa) significantly reduced the biofilm formation, virulence and pathogenicity to mice. Mechanism analysis proved that this maybe because cas3 can lead to the down-regulation of biofilm formation related factors and ompA.

Tingting Guo
Jie Yang
Guocai Li
ResearchOpen Access14 May 2025
Communications Biology

Volume: 8, P: 1-10
NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Gα

LIN-5 acts at the cortex with Ga to control spindle positioning but is also localized at spindle poles. The LIN-5 interacting protein ASPM-1 and calmodulin are required for its recruitment to spindle poles and the LIN-5/ASPM-1/calmodulin complex regulates meiotic spindle positioning.

Monique van der Voet
Christian W. H. Berends
Sander van den Heuvel
Research15 Feb 2009
Nature Cell Biology

Volume: 11, P: 269-277
The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans

R. Mako Saito
Audrey Perreault
Sander van den Heuvel
Research11 Jul 2004
Nature Cell Biology

Volume: 6, P: 777-783
A novel minor histocompatibility antigen recognized by HLA-A31 restricted cytotoxic T lymphocytes generated from HLA-identical bone marrow donor lymphocytes

M Yazaki
T Takahashi
Y Wada
Research23 Jul 1999
Bone Marrow Transplantation

Volume: 24, P: 129-137
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Bone marrow transplantation in pediatric patients with therapy-related myelodysplasia and leukemia

AM Leahey
DL Friedman
NJ Bunin
Research22 Dec 1998
Bone Marrow Transplantation

Volume: 23, P: 21-25
Unmodified RNA sequences form unusual stable G-quadruplexes with potential anti-RSV and anti-angiogenesis applications

Stable G-quadruplex RNA sequences (90% in serum for 96 h) bind cell surface nucleolin, showing anti-viral (respiratory syncytial virus) and anti-angiogenic effects with low toxicity, offering potential for tumor and viral therapies.

Rui-Qing Tian
Yue Gao
Chao-Da Xiao
ResearchOpen Access21 Mar 2025
Communications Biology

Volume: 8, P: 1-14
A late Middle Pleistocene Denisovan mandible from the Tibetan Plateau

Fossil evidence indicates that Denisovans occupied the Tibetan Plateau in the Middle Pleistocene epoch and successfully adapted to this high-altitude hypoxic environments long before the regional arrival of modern Homo sapiens.

Fahu Chen
Frido Welker
Jean-Jacques Hublin
Research01 May 2019
Nature

Volume: 569, P: 409-412
Differential expression of SMAD3 transcripts is not regulated by cis-acting genetic elements but has a gender specificity

L Busque
C Belisle
C Perreault
Research08 Jan 2009
Genes & Immunity

Volume: 10, P: 192-196
Early career investigator highlight: May

Wissam Shalish
Comments & Opinion11 Apr 2018
Pediatric Research

Volume: 83, P: 917
TBC3711, an ET_A Receptor Antagonist, Reduces Neonatal Hypoxia-Induced Pulmonary Hypertension in Piglets

Thérèse Perreault
John W Berkenbosch
Johanne Baribeau
Research01 Sept 2001
Pediatric Research

Volume: 50, P: 374-383
Changes in Expression of Vascular Endothelial Growth Factor and Its Receptors in Neonatal Hypoxia-Induced Pulmonary Hypertension

Sophie Nadeau
Johanne Baribeau
Thérèse Perreault
Research01 Aug 2005
Pediatric Research

Volume: 58, P: 199-205

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