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Prion protein promotes copper toxicity in Wilson disease

This study reveals that prion protein (PrP) promotes copper toxicity in Wilson disease by facilitating copper endocytosis. The authors demonstrate that suppressing PrP reduces copper overload and liver damage, offering a potential therapeutic strategy for this fatal inherited disorder.

Raffaella Petruzzelli
Federico Catalano
Roman S. Polishchuk
ResearchOpen Access08 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Associations between the C677T and A1298C polymorphisms of MTHFR and the toxicity of methotrexate in childhood malignancies: a meta-analysis

C Zhu
Y W Liu
X L Wang
Research11 Jul 2017
The Pharmacogenomics Journal

Volume: 18, P: 450-459
A guide for the diagnosis and management of gastrointestinal stromal cell tumors

Gastrointestinal stromal cell tumors (GISTs) always have a degree of malignant potential, and, increasingly, they are diagnosed only on routine endoscopy. Sepe and Brugge provide a gastroenterologist's guide for GIST diagnosis and assessment of malignant potential. The authors of this Review also propose an algorithm for the treatment of localized GISTs that is especially useful for the management of incidentally diagnosed tumors.

Paul S. Sepe
William R. Brugge
Reviews14 Apr 2009
Nature Reviews Gastroenterology & Hepatology

Volume: 6, P: 363-371
Collagen and calcium-binding EGF domains 1 is frequently inactivated in ovarian cancer by aberrant promoter hypermethylation and modulates cell migration and survival

C A Barton
B S Gloss
P M O'Brien
ResearchOpen Access24 Nov 2009
British Journal of Cancer

Volume: 102, P: 87-96
DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

ERCC1 is involved in a number of DNA repair pathways including nucleotide excision repair. Here the authors showed that reduced transcription in Ercc1-deficient mouse livers and cells increases ATP levels, suppressing glycolysis and rerouting glucose into the pentose phosphate shunt that generates reductive stress.

Chiara Milanese
Cíntia R. Bombardieri
Pier G. Mastroberardino
ResearchOpen Access25 Oct 2019
Nature Communications

Volume: 10, P: 1-16
Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth

Tumour suppressors can be inactivated in cancer not only as a result of mutation, but also by proteolytic degradation. Here the authors show that, during glioma development, the accumulation of the ubiquitin ligase praja2 sustains tumour growth by degrading MOB1—a core component of the Hippo pathway.

Luca Lignitto
Antonietta Arcella
Antonio Feliciello
ResearchOpen Access07 May 2013
Nature Communications

Volume: 4, P: 1-13
5-AZA-2′-deoxycytidine synergic action with thymidine: kinetic interaction of its monophosphate and triphosphate with dCMP deaminase: 135

R L Momparler
M Rossi
S Sepe
Research01 Jul 1985
Pediatric Research

Volume: 19, P: 766
Association between methylenetetrahydrofolate reductase polymorphisms and the relapse of acute lymphoblastic leukemia: a meta-analysis

H-R He
S-Y Chen
J Lu
Research18 Mar 2014
The Pharmacogenomics Journal

Volume: 14, P: 432-438
Bacteria in cancer initiation, promotion and progression

The role of the microbiota in tumorigenesis has garnered considerable attention over the past two decades. In this Review, El Tekle and Garrett explore the current and evolving understanding of microbiota in cancers of various internal organs, as well as highlighting opportunities for targeting bacteria for cancer prevention, diagnostics and treatment.

Geniver El Tekle
Wendy S. Garrett
Reviews03 Jul 2023
Nature Reviews Cancer

Volume: 23, P: 600-618
112 ELEVATION OF PROSTAGLANDIN LEVELS IN PREGNANCIES COMPLICATED BY PREMATURE RUPTURE OF THE MEMBRANES (PROM)

Peter J Thompson
Anne Greenough
Andre‘ Lopez-Bernal
Research01 Dec 1991
Pediatric Research

Volume: 30, P: 646
912 CILIARY MORPHOLOGY AND CARDIAC MALROTATION

Park S Gerald
Samuel R Schuster
Eveline E Schneeberqer
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 515
FUNCTIONALLY ABNORMAL α₂-MACROGLOBULIN (α₂M) IN CYSTIC FIBROSIS (CF)

Emmanuel Shapira
Christina Martin
Hanry Nadlar
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 464
CYSTIC FIBROSIS: EVIDENCE OF RELATIONSHIP BETWEEN SEX OF THE CARRIER AND SEX RATIO OF ITS OFFSPRING

F Gloria-Bottini
M Antonelli
C D Cook
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 456
HYPERAMMONEMIA WITH PARTIAL CARBAMYL PHOSPHATE SYNTHASE (CPS) DEFICIENCY RESPONSIVE TO ARGININE THERAPY

Allen M Glasgow
Sheldon Orloff
Joseph P Schulman
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 456
ENZYME MANIPULATION: EVALUATION OF ORAL ZnSO₄ SUP-PLEMENTATION IN MANNOSIDOSIS TYPE II

Gregory A Grabowski
Linda L Walling
Robert J Desnick
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 456
METABOLIC PORTOSYSTEMIC SHUNTS“ IN ORNITHINE TRANS-CARBAMYLASE DEFICIENCY?

Allen M Glasgow
Wellington Hung
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 456
CLEFT PALATE: A MOLECULAR MECHANISM LINKED TO THE H-2 LOCUS

Allen S Goldman
Masuyuki Katsumata
David L Gasser
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 456
ENZYME THERAPY: EVIDENCE FOR TWO DISTINCT RECEPTORS THAT MEDIATE UPTAKE AND CLEARANCE OF HUMAN β-GLUCURONIDASE

William S Sly
Daniel T Achord
Frederick E Brot
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 464
A SINGLE SYSTEM FOR THE EVALUATION OF PURINE AND PYRIMIDINE NUCLEOSIDES AND BASES TOGETHER WITH THEIR ANALOGUES IN BIOLOGICAL FLUIDS: 137

George S Morris
H Anne Simmonds
Research01 Jul 1985
Pediatric Research

Volume: 19, P: 766
TFEB controls syncytiotrophoblast formation and hormone production in placenta

Marcella Cesana
Gennaro Tufano
Andrea Ballabio
ResearchOpen Access04 Jul 2024
Cell Death & Differentiation

Volume: 31, P: 1439-1451
Autologous SCT with a dose-reduced BU and CY regimen in older patients with non-Hodgkin's lymphoma

R Z Yusuf
B Dey
K K Ballen
Research15 Sept 2008
Bone Marrow Transplantation

Volume: 43, P: 37-42
Role of the Aspartyl-Asparaginyl-β-Hydroxylase Gene in Neuroblastoma Cell Motility

Paul S Sepe
Stephanie A Lahousse
Suzanne M de la Monte
Research01 Jul 2002
Laboratory Investigation

Volume: 82, P: 881-891
Erratum: A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

A Tosco
F De Gregorio
V Raia
Amendments and Corrections22 Jul 2016
Cell Death & Differentiation

Volume: 24, P: 1305
Mitochondrial AKAP1 supports mTOR pathway and tumor growth

Laura Rinaldi
Maria Sepe
Antonio Feliciello
ResearchOpen Access01 Jun 2017
Cell Death & Disease

Volume: 8, P: e2842
A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR

A Tosco
F De Gregorio
V Raia
ResearchOpen Access01 Apr 2016
Cell Death & Differentiation

Volume: 23, P: 1380-1393
Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis

F Rossin
M D'Eletto
M Piacentini
Research25 Jul 2014
Cell Death & Differentiation

Volume: 22, P: 408-418
Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins

M D'Eletto
M G Farrace
M Piacentini
Research10 Feb 2012
Cell Death & Differentiation

Volume: 19, P: 1228-1238
53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope

J-L Perfettini
R Nardacci
G Kroemer
Research30 Oct 2009
Cell Death & Differentiation

Volume: 17, P: 811-820
praja2 regulates KSR1 stability and mitogenic signaling

L Rinaldi
R Delle Donne
A Feliciello
ResearchOpen Access19 May 2016
Cell Death & Disease

Volume: 7, P: e2230
RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho

Maria Vittoria Barone
Leandra Sepe
Massimo Santoro
Research01 Nov 2001
Oncogene

Volume: 20, P: 6973-6982
Correspondence: Osteonecrosis in childhood acute lymphoblastic leukemia: a retrospective cohort study of the Italian Association of Pediatric Haemato-Oncology (AIEOP)

Rosanna Parasole
Maria G. Valsecchi
Valentino Conter
CorrespondenceOpen Access15 Nov 2018
Blood Cancer Journal

Volume: 8, P: 1-6

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