Nature Search

Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty

To better understand the etiology of frailty, the authors perform a large genetic study. They identified 45 additional variants and implicated MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism and cellular signaling.

Jonathan K. L. Mak
Chenxi Qin
Juulia Jylhävä
ResearchOpen Access05 Aug 2025
Nature Aging

Volume: 5, P: 1589-1600
Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

A genome-wide association study suggests 41 previously unreported loci on top of the 23 known loci that influence the disease risk for lumbar disc herniations. Many of these loci harbour genes implicated in disc structure and inflammation, as well as genes related to the nervous system and nerve function.

Ville Salo
Juhani Määttä
Johannes Kettunen
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Cardiovascular diseases (CVD) are associated with plasma lipid levels. Here, Tabassum et al. perform genome-wide association studies for lipidomic profiles with 141 (non-standard) lipid species which highlights shared genetic loci with CVD and that traditional lipids have low genetic correlation with other lipids.

Rubina Tabassum
Joel T. Rämö
Samuli Ripatti
ResearchOpen Access24 Sept 2019
Nature Communications

Volume: 10, P: 1-14
The epigenome as a therapeutic target in prostate cancer

Epigenetic changes, such as gain and loss of DNA methylation and altered histone modifications, are a hallmark of human cancer. The role of the epigenome in prostate cancer is well recognized. In this Review, the authors discuss the different epigenetic modifications which can contribute to cancer progression, and consider the therapeutic potential of targeting the epigenome in patients with prostate cancer.

Antoinette S. Perry
R. William G. Watson
Donal Hollywood
Reviews09 Nov 2010
Nature Reviews Urology

Volume: 7, P: 668-680
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Narcolepsy has genetic and environmental risk factors, but the specific genetic risk loci and interaction with environmental triggers are not well understood. Here, the authors identify genetic loci for narcolepsy, suggesting infection as a trigger and dendritic and helper T cell involvement.

Hanna M. Ollila
Eilon Sharon
Emmanuel J. Mignot
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-13
Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Many genetic factors that contribute to uterine leiomyomata (UL) - the most common tumours of the female genital tract - remain to be discovered. Here, the authors conduct a UL meta-genome-wide association study, and find loci related to altered muscle tissue biology that are associated with UL.

Eeva Sliz
Jaakko S. Tyrmi
Johannes Kettunen
ResearchOpen Access01 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

The burden of mosaic chromosomal alterations in blood-derived DNA, a type of clonal hematopoiesis, is associated with an increased risk for diverse types of infections, including sepsis and pneumonia.

Seyedeh M. Zekavat
Shu-Hong Lin
Pradeep Natarajan
Research07 Jun 2021
Nature Medicine

Volume: 27, P: 1012-1024
Providing patients with pharmacogenetic test results affects adherence to statin therapy: results of the Additional KIF6 Risk Offers Better Adherence to Statins (AKROBATS) trial

S L Charland
B C Agatep
E J Stanek
Research27 Aug 2013
The Pharmacogenomics Journal

Volume: 14, P: 272-280
miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

E J Noonan
R F Place
R Dahiya
Research02 Mar 2009
Oncogene

Volume: 28, P: 1714-1724
Narcolepsy as a potential risk factor for Schizophrenia

Reyhane Eghtedarian
Anniina M. Tervi
Hanna M. Ollila
ResearchOpen Access17 Feb 2025
Translational Psychiatry

Volume: 15, P: 1-10
Novel loci and biomedical consequences of iron homoeostasis variation

The largest meta-analysis of GWASs of hepcidin and sTfR identified 43 genomic loci, of which 15 new. Mendelian randomisation revealed associations of systemic iron status and iron-related loci with selected health outcomes across multiple domains.

Elias Allara
Steven Bell
Emanuele Di Angelantonio
ResearchOpen Access06 Dec 2024
Communications Biology

Volume: 7, P: 1-17
Role of diet in prostate cancer: the epigenetic link

D P Labbé
G Zadra
M Brown
ReviewsOpen Access22 Dec 2014
Oncogene

Volume: 34, P: 4683-4691
A FinnGen pilot clinical recall study for Alzheimer’s disease

Valtteri Julkunen
Claudia Schwarz
Heiko Runz
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-15
BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation

S Shabbeer
D Omer
R I Yarden
Research17 Dec 2012
Oncogene

Volume: 32, P: 5005-5016
NTHL1 is a recessive cancer susceptibility gene

Anna K. Nurmi
Liisa M. Pelttari
Heli Nevanlinna
ResearchOpen Access30 Nov 2023
Scientific Reports

Volume: 13, P: 1-14
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

A genome-wide association study identifies MFGE8 as protective against coronary atherosclerosis in European and East Asian populations.

Sanni E. Ruotsalainen
Ida Surakka
Samuli Ripatti
ResearchOpen Access17 Aug 2022
Communications Biology

Volume: 5, P: 1-16
Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

Max Tamlander et al. combine polygenic risk scores and clinical assessments to improve prediction of coronary artery disease and type 2 diabetes in European cohorts. Taken together, their results provide a useful method for preliminary cardiometabolic risk assessment in patients.

Max Tamlander
Nina Mars
Samuli Ripatti
ResearchOpen Access23 Feb 2022
Communications Biology

Volume: 5, P: 1-13

Search

Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

The epigenome as a therapeutic target in prostate cancer

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Providing patients with pharmacogenetic test results affects adherence to statin therapy: results of the Additional KIF6 Risk Offers Better Adherence to Statins (AKROBATS) trial

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

Narcolepsy as a potential risk factor for Schizophrenia

Novel loci and biomedical consequences of iron homoeostasis variation

Role of diet in prostate cancer: the epigenetic link

A FinnGen pilot clinical recall study for Alzheimer’s disease

BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation

NTHL1 is a recessive cancer susceptibility gene

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

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