Nature Search

Sediment loads in the Amazon River

ROBERT H. MEADE
CARL F. NORDIN Jr
JOHN M. EDMOND
Research01 Mar 1979
Nature

Volume: 278, P: 161-163
Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance

Ambroziak, Nencini, Pohle and colleagues identify a slowly emerging plasticity mechanism in a discrete set of hypothalamic preoptic neurons that is triggered by long-term heat exposure and that drives thermal acclimation to promote heat tolerance in mice.

Wojciech Ambroziak
Sara Nencini
Jan Siemens
ResearchOpen Access09 Dec 2024
Nature Neuroscience

Volume: 28, P: 346-360
A brave new world for dynein

Lawrence S. B. Goldstein
Ron D. Vale
News & Views15 Aug 1991
Nature

Volume: 352, P: 569-570
Rapid, biphasic CRF neuronal responses encode positive and negative valence

Animals must determine quickly whether any given environmental stimuli are beneficial or detrimental. This work reveals a novel strategy to encode opposing valences by a single population of CRF neurons in the hypothalamus.

Jineun Kim
Seongju Lee
Greg S. B. Suh
Research04 Mar 2019
Nature Neuroscience

Volume: 22, P: 576-585
RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS

The RNA methyltransferase activity of SPOUT1/CENP-32 is crucial for accurate mitotic spindle organization. Here, the authors describe a neurodevelopmental disorder caused by bi-allelic pathogenic SPOUT1 variants with reduced activity and compromised function in spindle organization.

Avinash V. Dharmadhikari
Maria Alba Abad
Jun Liao
ResearchOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1-24
Crystal structure of the intensely sweet protein monellin

Craig Ogata
Marcos Hatada
Sung-Hou Kim
Research20 Aug 1987
Nature

Volume: 328, P: 739-742
The murine T-cell receptor uses a limited repertoire of expressed V_β gene segments

Richard K. Barth
Byung S. Kim
Leroy Hood
Research01 Aug 1985
Nature

Volume: 316, P: 517-523
Greenwich as a Meteorological Observatory

H. S. EATON
Research03 May 1877
Nature

Volume: 16, P: 7-8
Highly active cyclic and bicyclic somatostatin analogues of reduced ring size

DANIEL F. VEBER
FREDERICK W. HOLLY
RICHARD SAPERSTEIN
Research01 Aug 1979
Nature

Volume: 280, P: 512-514
Mining drives extensive deforestation in the Brazilian Amazon

Industrial mining contributes to deforestation in the Amazon, and the extent of effect could occur beyond areas of land explicitly permitted for mining. Here, Sonter et al. show that deforestation in 70-km buffer zones around mines has led to an estimated 9% of Brazilian Amazon deforestation since 2005.

Laura J. Sonter
Diego Herrera
Britaldo S. Soares-Filho
ResearchOpen Access18 Oct 2017
Nature Communications

Volume: 8, P: 1-7
Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells

Interleukin-2 (IL-2) is a T-cell proliferating factor used for cancer immunotherapy. Here, the authors develop a long-lived variant of IL-2 that, mutated in its binding domain, drives a much more potent tumour regression by depleting CD25⁺ CD4⁺regulatory T-cells via targeting them for phagocytosis.

Rodrigo Vazquez-Lombardi
Claudia Loetsch
Daniel Christ
ResearchOpen Access12 May 2017
Nature Communications

Volume: 8, P: 1-12
A short timescale for terrestrial planet formation from Hf–W chronometry of meteorites

Qingzhu Yin
S. B. Jacobsen
F. Albarède
Research29 Aug 2002
Nature

Volume: 418, P: 949-952
Regional variations in hepatocellular carcinoma incidence, routes to diagnosis, treatment and survival in England

Anya Burton
Vinay K. Balachandrakumar
Tim J. S. Cross
ResearchOpen Access26 Nov 2021
British Journal of Cancer

Volume: 126, P: 804-814
The muscle in kinesin

The first high resolution structures of the kinesin and NCD motor proteins reveal their surprising similarity to myosin but leave open the tantalizing question of what properties determine the directionality of movement along microtubules.

Roman Sakowicz
Lawrence S.B. Goldstein
News & Views01 May 1996
Nature Structural Biology

Volume: 3, P: 404-407
Possible Systematic Error in the Measurement of Normal Stress Differences in Polymer Solutions in Steady Shear Flow

J. M. BROADBENT
A. KAYE
D. G. VALE
Research06 Jan 1968
Nature

Volume: 217, P: 55-56
Microscale geometrical modulation of PIEZO1 mediated mechanosensing through cytoskeletal redistribution

Cells sense mechanical force through PIEZO1 channels. Here, authors show that both microgeometry and aspiration force mediate the PIEZO1 activity, and also alter F-actin organization, further amplifying PIEZO1 activity along membrane.

Haoqing Jerry Wang
Yao Wang
Lining Arnold Ju
ResearchOpen Access29 Jun 2024
Nature Communications

Volume: 15, P: 1-17
Allele-specific replication timing of imprinted gene regions

D. Kitsberg
S. Selig
H. Cedar
Research29 Jul 1993
Nature

Volume: 364, P: 459-463
The β-subunit of follicle-stimulating hormone is deleted in patients with aniridia and Wilms' tumour, allowing a further definition of the WAGR locus

Tom Glaser
William H. Lewis
D. E. Housman
Research26 Jun 1986
Nature

Volume: 321, P: 882-887
A Numerical Coincidence

H. P. HOLLIS
Research15 Apr 1933
Nature

Volume: 131, P: 550
A role for melanin-concentrating hormone in the central regulation of feeding behaviour

Daqing Qu
David S. Ludwig
Eleftheria Maratos-Flier
Research21 Mar 1996
Nature

Volume: 380, P: 243-247
Is somatostatin an excitatory transmitter in the hippocampus?

JANE DODD
J. S. KELLY
Research22 Jun 1978
Nature

Volume: 273, P: 674-675
Age and pattern of the southern high-latitude continental end-Permian extinction constrained by multiproxy analysis

The continental record of the end Permian mass extinction is limited, especially from high paleolatitudes. Here, Fielding et al. report a multi-proxy Permo-Triassic record from Australia, resolving the timing of local terrestrial plant extinction and the relationship with environmental changes.

Christopher R. Fielding
Tracy D. Frank
James L. Crowley
ResearchOpen Access23 Jan 2019
Nature Communications

Volume: 10, P: 1-12
Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose that type II NKT TCRs may adapt multiple CD1d docking modes to maximise antigen recognition efficacy.

Catarina F. Almeida
Srinivasan Sundararaj
Jamie Rossjohn
ResearchOpen Access20 Nov 2019
Nature Communications

Volume: 10, P: 1-14
A_2AR eGFP reporter mouse enables elucidation of A_2AR expression dynamics during anti-tumor immune responses

Adenosine is an immunosuppressive metabolite known to limit anti-tumor immune responses. Here the authors report the characterization of an adenosine A2A receptor (A2AR) eGFP reporter mouse, providing immunological insights into the biology of A2AR expression in the context of anti-tumor immunity.

Kirsten L. Todd
Junyun Lai
Paul A. Beavis
ResearchOpen Access01 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Gonadotropin releasing hormone agonists stimulate meiotic maturation of follicle-enclosed rat oocytes in vitro

T. Hillensjö
W. J. LeMaire
Research11 Sept 1980
Nature

Volume: 287, P: 145-146
Retrograde step for microtubules

Jeremy S. Hyams
News & Views18 Nov 1987
Nature

Volume: 330, P: 106
Genomic history of coastal societies from eastern South America

The authors report genome-wide data from 34 ancient individuals spanning the Holocene, from what is now Brazil, illuminating connections and disjoints between Sambaqui shellmound societies and preceding and later peoples.

Tiago Ferraz
Ximena Suarez Villagran
Cosimo Posth
ResearchOpen Access31 Jul 2023
Nature Ecology & Evolution

Volume: 7, P: 1315-1330
New reptile shows dinosaurs and pterosaurs evolved among diverse precursors

A well-preserved partial skeleton (Upper Triassic, Brazil) of the new lagerpetid Venetoraptor gassenae gen. et sp. nov. offers a more comprehensive look into the skull and ecology of dinosaur and pterosaur precursors.

Rodrigo T. Müller
Martín D. Ezcurra
Sterling J. Nesbitt
Research16 Aug 2023
Nature

Volume: 620, P: 589-594
Erythrocyte ATP: D-Fructose-6-phosphate I-Phosphotransferase (Phosphofructokinase) Activity in Children with Normal/G Trisomic Mosaic Down's Syndrome and in Normal and Down's Syndrome Controls

PHILIP F. BENSON
BRIAN LINACRE
ANGELA I. TAYLOR
Research21 Dec 1968
Nature

Volume: 220, P: 1235-1236
Heavyweight funders back central site for life-sciences preprints

Coalition of scientists and research agencies argue for a one-stop shop server.

Ewen Callaway
News16 Feb 2017
Nature

Volume: 542, P: 283-284
Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster

Lucy Anderson
M. Florencia Camus
Pedro F. Vale
ResearchOpen Access28 Jun 2022
Heredity

Volume: 129, P: 225-232
Human β-thromboglobulin inhibits PGI₂ production and binds to a specific site in bovine aortic endothelial cells

W. Hope
T. J. Martin
F. J. Morgan
Research08 Nov 1979
Nature

Volume: 282, P: 210-212
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice

Using several orthogonal loss-of-function approaches, Huang et al. provide a detailed assessment of the quantitative contribution of δ cell paracrine signalling to the glycaemic set point in mice.

Jessica L. Huang
Mohammad S. Pourhosseinzadeh
Mark O. Huising
Research09 Jan 2024
Nature Metabolism

Volume: 6, P: 61-77
Functional corticotropin releasing factor receptors in the primate peripheral sympathetic nervous system

Robert Udelsman
James P. Harwood
Greti Aguilera
Research09 Jan 1986
Nature

Volume: 319, P: 147-150
The role of the social network in the study of adherence to diabetic retinopathy screening programs

Andreia Penso Pereira
Ana Afonso
Fernando Buarque de Lima Neto
ResearchOpen Access26 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs

Here, English et al. show that after expanding in lymphoid tissues, CD4⁺ and CD8⁺ T cells recognising hepatic antigens migrate into specialised vascular liver areas where CD4⁺ T cells locally license hepatic dendritic cells and further expand CD8⁺ T cell numbers.

Kieran English
Rain Kwan
Patrick Bertolino
ResearchOpen Access10 Feb 2024
Nature Communications

Volume: 15, P: 1-17
A planet orbiting the neutron star PSR1829–10

M. Bailes
A. G. Lyne
S. L. Shemar
Research25 Jul 1991
Nature

Volume: 352, P: 311-313
Genetic evidence supports three previously described species of greater glider, Petauroides volans, P. minor, and P. armillatus

Denise C. McGregor
Amanda Padovan
Kara N. Youngentob
ResearchOpen Access06 Nov 2020
Scientific Reports

Volume: 10, P: 1-11
Bombesin suppresses feeding in rats

J. Gibbs
D. J. Fauser
S. P. Maddison
Research08 Nov 1979
Nature

Volume: 282, P: 208-210
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase

Toll-like receptor 7 (TLR7) normally recognizes exogenous single-stranded RNA for the activation of innate immunity. Here the authors show that TLR7 may also contribute, via the modulation of mast cell functions, to experimental, cigarette smoke-induced mouse models of emphysema, thereby hinting TLR7 as a potential therapeutic target for human lung inflammation.

Gang Liu
Tatt Jhong Haw
Philip M. Hansbro
ResearchOpen Access14 Nov 2023
Nature Communications

Volume: 14, P: 1-24
ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27

While HER2-targeted therapies such as trastuzumab can be effective in patients with breast cancer, resistance often develops. Here, the authors demonstrate that the histone reader ZYMND8 promotes glycerophospholipid metabolic reprogramming via c-Myc and cPLA2α to increase secretion of IL-27, mediating resistance to HER2-targeted antibodies in preclinical models of breast cancer.

Yong Wang
Yanan Wang
Weibo Luo
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-19
The resilience of postglacial hunter-gatherers to abrupt climate change

A high-resolution local palaeoclimatic archive is correlated to the early Holocene human behavioural record at the British Mesolithic site of Star Carr. Despite environmental stresses at this time, intensive human activity persisted over centuries, suggesting resilience to climate change.

Simon Blockley
Ian Candy
Nicky Milner
Research26 Mar 2018
Nature Ecology & Evolution

Volume: 2, P: 810-818
The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer

Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic reprogramming.

Emily Golden
Rabab Rashwan
Pilar Blancafort
ResearchOpen Access26 Mar 2021
Nature Communications

Volume: 12, P: 1-22
Detection of mosaic and population-level structural variants with Sniffles2

Sniffles2 detects mosaic structural variation from bulk long-read sequencing data.

Moritz Smolka
Luis F. Paulin
Fritz J. Sedlazeck
ResearchOpen Access02 Jan 2024
Nature Biotechnology

Volume: 42, P: 1571-1580
Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal disorders and common complex skeletal diseases.

Scott E. Youlten
John P. Kemp
Peter I. Croucher
ResearchOpen Access05 May 2021
Nature Communications

Volume: 12, P: 1-21
Boron isotope evidence for the involvement of non-marine evaporites in the origin of the Broken Hill ore deposits

John F. Slack
Martin R. Palmer
Brian P. J. Stevens
Research28 Dec 1989
Nature

Volume: 342, P: 913-916
γ Interferon induced by S. aureus protein A augments natural killing and ADCC

William J. Catalona
Timothy L. Ratliff
Robert E. McCool
Research07 May 1981
Nature

Volume: 291, P: 77-79
Evidence other than Optical Radar Backscatter for the Existence of an Accumulation of Dust between 70 and 140 km at Low Latitudes

S. K. POULTNEY
Research01 Dec 1966
Nature

Volume: 212, P: 1558-1559
Pain-causing stinging nettle toxins target TMEM233 to modulate Na_V1.7 function

Voltage-gated sodium channels function as multiprotein signaling complexes. Here, authors show that the dispanin TMEM233 is essential for activity of stinging nettle toxins and that co-expression of TMEM233 modulates the gating properties of Na_V1.7.

Sina Jami
Jennifer R. Deuis
Irina Vetter
ResearchOpen Access28 Apr 2023
Nature Communications

Volume: 14, P: 1-16
An Ice Age JWST inventory of dense molecular cloud ices

Using JWST, the molecules seen in planetary atmospheres can be traced back to their cold origins in ices formed in dense interstellar clouds, before the onset of star formation, revealing that chemical diversity and complexity is achieved early.

M. K. McClure
W. R. M. Rocha
H. Linnartz
Research23 Jan 2023
Nature Astronomy

Volume: 7, P: 431-443

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