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Showing 101–150 of 227 results

Advanced filters: Author: S Varghese Clear advanced filters

Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation

CRISPR–Cas9-based method to introduce site-specific S-GlcNAcylation enables dissection of the roles of protein O-GlcNAcylation. S-GlcNAc, a hydrolytically stable structural mimic of O-GlcNAc, is recognized by a range of O-GlcNAc-binding proteins.

Andrii Gorelik
Sergio Galan Bartual
Daan M. F. van Aalten
Research06 Nov 2019
Nature Structural & Molecular Biology

Volume: 26, P: 1071-1077
1037 ADHERENCE OF HAEMOPHILUS INFLUENZAE b TO EPITHELIAL CELLS OF CHILDREN

Richard M Lampe
Sheldon L Kaplan
Ralph D Feigin
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 615
Detecting vertical root fractures

V. S. Varghese
P. K. Atwal
J. M. Cherian
Research26 Nov 2021
British Dental Journal

Volume: 231, P: 601-602
HYPERTENSION IN A NEW YORK CITY HIGH SCHOOL POPULATION: PREVALENCE AND EVALUATION

Lenore S Levine
John E Lewy
Maria I New
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 352
Author Correction: A MHz-repetition-rate hard X-ray free-electron laser driven by a superconducting linear accelerator

W. Decking
S. Abeghyan
D. Zybin
Amendments and Corrections27 Jul 2020
Nature Photonics

Volume: 14, P: 650
Structural basis of autoregulation of phenylalanine hydroxylase

Bostjan Kobe
Ian G. Jennings
Bruce E. Kemp
Research01 May 1999
Nature Structural Biology

Volume: 6, P: 442-448
Effect of material deprivation on Epstein–Barr virus infection in Hodgkin’s disease in the West Midlands

K Flavell
C Constandinou
P Murray
ResearchOpen Access09 Apr 1999
British Journal of Cancer

Volume: 80, P: 604-608
Variants in CPA1 are strongly associated with early onset chronic pancreatitis

Heiko Witt, Miklós Sahin-Tóth and colleagues show that loss-of-function variants in CPA1 are strongly associated with early onset chronic pancreatitis. On the basis of their findings, they propose that the mechanism may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity.

Heiko Witt
Sebastian Beer
Miklós Sahin-Tóth
Research18 Aug 2013
Nature Genetics

Volume: 45, P: 1216-1220
Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection

Rumen microbiome biology gets a boost with the release of 410 high-quality reference genomes from the Hungate1000 project.

Rekha Seshadri
Sinead C Leahy
William J Kelly
ResearchOpen Access19 Mar 2018
Nature Biotechnology

Volume: 36, P: 359-367
Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

Changes in active chromatin marks in old activated satellite cells lead to Hoxa9 activation, which induces the expression of developmental pathway genes with a known inhibitory effect on satellite cell function and muscle regeneration in aged mice.

Simon Schwörer
Friedrich Becker
K. Lenhard Rudolph
Research30 Nov 2016
Nature

Volume: 540, P: 428-432
What are the information priorities for cancer patients involved in treatment decisions? An experienced surrogate study in Hodgkin's disease

S Turner
EJ Maher
G Vaughan Hudson
Research01 Jan 1996
British Journal of Cancer

Volume: 73, P: 222-227
Otolith chemistry suggests population heterogeneity within a genetically homogeneous Indian scad population along Indian coast

Anjaly Jose
Sandhya Sukumaran
A. Gopalakrishnan
ResearchOpen Access08 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Author Correction: A genomic catalog of Earth’s microbiomes

Stephen Nayfach
Simon Roux
Emiley A. Eloe-Fadrosh
Amendments and CorrectionsOpen Access01 Apr 2021
Nature Biotechnology

Volume: 39, P: 521
Publisher Correction: A genomic catalog of Earth’s microbiomes

Stephen Nayfach
Simon Roux
Emiley A. Eloe-Fadrosh
Amendments and CorrectionsOpen Access18 Nov 2020
Nature Biotechnology

Volume: 39, P: 520
Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage: a randomized, crossover, placebo-controlled trial

Queralt Asla
Maite Garrido
Anna Aulinas
ResearchOpen Access18 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
Priorities for cancer research in low- and middle-income countries: a global perspective

Radical rethinking is needed to address the burning issues in cancer care in low- and middle-income countries. In this Perspective, the authors outline the main challenges and top priorities for cancer research now and into the future.

C. S. Pramesh
Rajendra A. Badwe
Elisabete Weiderpass
Reviews19 Apr 2022
Nature Medicine

Volume: 28, P: 649-657
The BRCA mutation spectrum among breast and ovarian cancers in India: highlighting the need to screen BRCA1 185delAG among South Indians

Ajoy Oommen John
Ashish Singh
Aaron Chapla
Research28 Mar 2024
European Journal of Human Genetics

Volume: 32, P: 1319-1326
Monomeric, porous type II collagen scaffolds promote chondrogenic differentiation of human bone marrow mesenchymal stem cells in vitro

M. Tamaddon
M. Burrows
E. Gentleman
ResearchOpen Access03 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Phase I/pharmacokinetic/biochemical study of the nitroimadazole hypoxic cell sensitiser SR2508 (etanidazole) in combination with cyclophosphamide

PJ O'Dwyer
FP LaCreta
RL Comis
Research01 Oct 1993
British Journal of Cancer

Volume: 68, P: 756-766
Comparative Microarray Analysis of Gene Expression During Activation of Human Peripheral Blood T Cells and Leukemic Jurkat T Cells

Zhaosheng Lin
G Chris Fillmore
Megan S Lim
Research01 Jun 2003
Laboratory Investigation

Volume: 83, P: 765-776
Selective toxicity of nitracrine to hypoxic mammalian cells

W R Wilson
W A Denny
J C Probert
Research01 Feb 1984
British Journal of Cancer

Volume: 49, P: 215-223
Structure–function assessment in glaucoma based on perimetric sensitivity and en face optical coherence tomography images of retinal nerve fiber bundles

Muhammed S. Alluwimi
William H. Swanson
Rizwan Malik
ResearchOpen Access13 Feb 2023
Scientific Reports

Volume: 13, P: 1-8
Genetic variability in the regulation of gene expression in ten regions of the human brain

Expression quantitative trait loci (eQTLs) are genomic regions that regulate gene expression. Here the authors provide a publicly available data set of exon-level eQTLs across the human brain. This includes many genome-wide association study (GWAS) hits for neurological and psychiatric disorders.

Adaikalavan Ramasamy
Daniah Trabzuni
Michael E Weale
Research31 Aug 2014
Nature Neuroscience

Volume: 17, P: 1418-1428
De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development

Jeanne Amiel, Bernd Wollnik, Bruno Reversade and colleagues report de novo missense mutations in SMCHD1 in patients with Bosma arhinia microphthalmia syndrome (BAMS) and isolated arhinia. Mechanistic studies support a key role for SMCHD1 in nasal development and suggest that the mutations in patients may function via a gain-of-function mechanism.

Christopher T Gordon
Shifeng Xue
Bruno Reversade
Research09 Jan 2017
Nature Genetics

Volume: 49, P: 249-255
Outcome of children with resistant and relapsed Hodgkin's disease

ND James
JE Kingston
JS Malpas
Research01 Dec 1992
British Journal of Cancer

Volume: 66, P: 1155-1158
Psychological distress after cancer cure: a survey of 459 Hodgkin's disease survivors

JH Loge
AF Abrahamsen
S Kaasa
Research01 Sept 1997
British Journal of Cancer

Volume: 76, P: 791-796
A series of genetically confirmed congenital lipodystrophy and diabetes in adult southern Indian patients

Remya Rajan
Aaron Chapla
Nihal Thomas
ResearchOpen Access16 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
Adipose-derived stem cells: an upcoming novel therapeutic in the management of Erectile dysfunction post radical prostatectomy in prostate cancer patients

Gargi Digholkar
Ryan Varghese
Rohit Sharma
Reviews05 Mar 2024
International Journal of Impotence Research

Volume: 36, P: 818-819
Tidings from the Tides–De novo transcriptome assembly of the endemic estuarine bivalve Villorita cyprinoides

Summaya Rahuman
N. S. Jeena
P. K. Asokan
ResearchOpen Access02 Jul 2024
Scientific Data

Volume: 11, P: 1-10
Anthropometric prediction models of body composition in 3 to 24month old infants: a multicenter international study

Vithanage Pujitha Wickramasinghe
Shabina Ariff
Ayesha Yameen
ResearchOpen Access20 Sept 2024
European Journal of Clinical Nutrition

Volume: 78, P: 943-951
Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model

K A Scott
H Holdsworth
S Dias
ResearchOpen Access14 Nov 2000
British Journal of Cancer

Volume: 83, P: 1538-1543
CD36 in chronic kidney disease: novel insights and therapeutic opportunities

CD36 has important roles in lipid homeostasis, metabolic inflammation, reprogramming of energy metabolism, apoptosis and kidney fibrosis. Here, the authors discuss these roles as well as the regulation and post-translational modification of CD36 and its potential as a biomarker and a therapeutic target for kidney disease.

Xiaochun Yang
Daryl M. Okamura
Xiong Z. Ruan
Reviews18 Sept 2017
Nature Reviews Nephrology

Volume: 13, P: 769-781
Evaluation of adjuvant psychological therapy for clinically referred cancer patients

S Greer
S Moorey
J Baruch
Research01 Feb 1991
British Journal of Cancer

Volume: 63, P: 257-260
Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Non-lysine ubiquitination activity of the E3 ubiquitin ligase MYCBP2 is identified by activity-based profiling; biochemical and structural analysis of MYCBP2 suggests the basis for its mechanism and specificity.

Kuan-Chuan Pao
Nicola T. Wood
Satpal Virdee
Research11 Apr 2018
Nature

Volume: 556, P: 381-385
An analysis of attitude toward infant sleep safety and SIDS risk reduction behavior among caregivers of newborns and infants

S Varghese
D Gasalberti
J C Chang
Research03 Sept 2015
Journal of Perinatology

Volume: 35, P: 970-973
Oncolytic herpes simplex virus armed with xenogeneic homologue of prostatic acid phosphatase enhances antitumor efficacy in prostate cancer

P Castelo-Branco
B J Passer
R L Martuza
Research11 Mar 2010
Gene Therapy

Volume: 17, P: 805-810
A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors

M Shimamura
H Nagasawa
S Inayama
ResearchOpen Access28 Jan 2003
British Journal of Cancer

Volume: 88, P: 307-313
Real-time study of spatio-temporal dynamics (4D) of physiological activities in alive biological specimens with different FOVs and resolutions simultaneously

Aiswarya K. S.
Sohela Sarkar
Mayanglambam Suheshkumar Singh
ResearchOpen Access12 Feb 2024
Scientific Reports

Volume: 14, P: 1-17
Cancer incidence among the south Asian and non-south Asian population under 30 years of age in Yorkshire, UK

M van Laar
P A McKinney
R G Feltbower
ResearchOpen Access14 Sept 2010
British Journal of Cancer

Volume: 103, P: 1448-1452
Financial toxicity associated with treatment of localized prostate cancer

Imber et al. summarize current knowledge of the risks of financial toxicity in patients with localized prostate cancer, proposing a framework of contributing factors, and discuss emerging assessment strategies to inform future research efforts.

Brandon S. Imber
Melissa Varghese
Daniel Gorovets
Reviews02 Dec 2019
Nature Reviews Urology

Volume: 17, P: 28-40
Functional kinomics establishes a critical node of volume-sensitive cation-Cl⁻ cotransporter regulation in the mammalian brain

Jinwei Zhang
Geng Gao
Kristopher T. Kahle
ResearchOpen Access26 Oct 2016
Scientific Reports

Volume: 6, P: 1-19
Fluorescence-based multifunctional light sheet imaging flow cytometry for high-throughput optical interrogation of live cells

One main obstacle of flow cytometry techniques is the inability to image internal structure of live cells on the go, posing challenges in deciphering their biological mechanisms. To overcome this limit, the authors devise a light-sheet-based multichannel, multisheet and multicolor volume imaging cytometry for interrogating cells flowing simultaneously through microfluidic channels.

Prakash Joshi
Prashant Kumar
Partha Pratim Mondal
ResearchOpen Access11 Jan 2024
Communications Physics

Volume: 7, P: 1-12
Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

Ana Catarina Ferreira
Brittany M. Hemmer
Joseph M. Castellano
ResearchOpen Access02 Nov 2023
Molecular Psychiatry

Volume: 28, P: 3943-3954
Milliwatt terahertz harmonic generation from topological insulator metamaterials

Topological insulator metamaterials bring nonlinear terahertz photonic technology a step closer by producing a third-harmonic output power close to a milliwatt.

Klaas-Jan Tielrooij
Alessandro Principi
Sergey Kovalev
ResearchOpen Access01 Nov 2022
Light: Science & Applications

Volume: 11, P: 1-8
Exosomal tau with seeding activity is released from Alzheimer’s disease synapses, and seeding potential is associated with amyloid beta

A novel assay quantifies depolarization of synaptosomes from Alzheimer’s cortex, and the authors show that tau released from these samples is unphosphorylated and C-terminal-truncated. Most tau is exosomal, and free-floating tau did not seed aggregation. Seeding activity was lower in tauopathy than AD, and strongly related to amyloid level.

Emily Miyoshi
Tina Bilousova
Karen Hoppens Gylys
ResearchOpen Access30 Aug 2021
Laboratory Investigation

Volume: 101, P: 1605-1617
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice

Melanie Schoof
Gefion Dorothea Epplen
Ulrich Schüller
ResearchOpen Access05 Jul 2023
Oncogenesis

Volume: 12, P: 1-11
A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model

Jesus Campagna
Patricia Spilman
Varghese John
ResearchOpen Access04 Dec 2018
Scientific Reports

Volume: 8, P: 1-15
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-4
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-4
Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine

S. Pützer
L. Varghese
M. Herling
Research25 Feb 2020
Leukemia

Volume: 34, P: 2513-2518

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