Proposed mechanism linking small vessel disease, typically white matter hyperintensity/lacune, with poor functional outcome. Seven incident events, neoplasm, heart disease, stroke, dementia, falls, pneumonia, and motor function impairment, potentially related to poor functional outcomes. In elderly patients, SVD significantly increases the risk of stroke, and moderately raises the risk of dementia, pneumonia, and motor impairment which may be related to senility. This relationship helps explain why patients with SVD are more likely to experience poor functional outcomes compared to those without SVD.
- Kazuo Kitagawa
- Sono Toi
- Kenichi Todo
