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Showing 1–8 of 8 results
Advanced filters: Author: S. Dyda Clear advanced filters

  • Dynamin is a protein that catalyses the fission of clathrin-coated endocytic vesicles from cellular membranes. To carry out fission, it must hydrolyse GTP. The mechanism by which it does so is unknown, although it does require dynamin's GTPase effector domain (GED). Here, the structure of a minimal GTPase–GED fusion protein constructed from human dynamin 1 is presented. The structure reveals the catalytic machinery and provides new insight into the mechanisms underlying dynamin-catalysed membrane fission.

    • Joshua S. Chappie
    • Sharmistha Acharya
    • Fred Dyda
    Research
    Nature
    Volume: 465, P: 435-440

  • Many mobile genetic elements, such as transposons, plasmids and viruses, must cleave their own DNA to effect transposition, replication or conjugation. Here, Chandler and colleagues describe the HUH endonucleases, which use a unique mechanism to cleave and rejoin single-stranded DNA in order to mobilize and disseminate such elements.

    • Michael Chandler
    • Fernando de la Cruz
    • Bao Ton-Hoang
    Reviews
    Nature Reviews Microbiology
    Volume: 11, P: 525-538

  • The integrase protein of retroviruses such as HIV-1 catalyses insertion of the viral genome into that of the host. Here, the long-awaited structure of the full-length integrase complex is predicted, revealing not only details of the biochemistry of the integration reaction, but also the means by which current inhibitors affect this process.

    • Stephen Hare
    • Saumya Shree Gupta
    • Peter Cherepanov
    Research
    Nature
    Volume: 464, P: 232-236

  • Coastal ecosystems are sensitive to changes in the quantity and lability of terrigenous dissolved organic matter (DOM) delivered by rivers. The lability of DOM is thought to decrease with age, but this view stems from work in watersheds where terrestrial plant and soil sources dominate streamwater DOM. Here, glaciated watersheds on the Gulf of Alaska are shown to be a source of old but labile dissolved organic matter, suggesting that glacial runoff is an important source of labile reduced carbon to marine ecosystems.

    • Eran Hood
    • Jason Fellman
    • Durelle Scott
    Research
    Nature
    Volume: 462, P: 1044-1047

  • Insertion of retrovirus genome into host genome to replicate is mediated by a tetramer of the virus-encoded integrase protein. The structure of a related integrase from prototype foamy virus bound to the cleaved viral DNA ends, a complex called the intasome, was previously revealed. These authors solve the structure of the intasome interacting with the target host DNA both before and after it is cleaved, revealing new details of the integration process that may help in designing improved inhibitors of HIV.

    • Goedele N. Maertens
    • Stephen Hare
    • Peter Cherepanov
    Research
    Nature
    Volume: 468, P: 326-329