Rho GTPases, which cycle between a GTP-bound active form and a GDP-bound inactive form, regulate cytoskeletal and cell adhesion dynamics and thus are crucial for the coordination of cell migration, cell polarity and cell cycle progression. Rho GTPases and their regulators (GEFs, GAPs and GDIs) are also regulated by post-translational modifications and the formation of regulatory complexes to ensure precise spatiotemporal Rho GTPase activation.
- Richard G. Hodge
- Anne J. Ridley
