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The Ocean Equity Index provides a systematic, twelve-criteria framework to assess and improve equity in ocean initiatives, projects and policies, producing structured data that guide evidence-based decisions and support more equitable outcomes for coastal communities and ecosystems.

Antigen presentation in skull bone marrow by hematopoietic stem and progenitor cells induces myelopoiesis and generates CD4⁺ regulatory T cells in a mouse model of ependymoma, promoting immune tolerance. Treatment with anti-GM-CSF antibody has antitumor effects that are augmented by immunotherapy.

In the phase 1/2 TRIDENT-1 trial, treatment of patients with NTRK fusion–positive advanced solid tumors with the tyrosine kinase inhibitor repotrectinib—selective for ROS1, TRKA−C and ALK—was safe and resulted in durable systemic and intracranial clinical response.

Women of reproductive age may have specific concerns relating to perceived impacts on fertility and menstrual cycles that make them hesitant to receive COVID-19 vaccination. In this study, the authors explore COVID-19 vaccine uptake rates in women of reproductive age using linked data for ~13 million women in England.

Here, the authors find that time-varying brain network analysis better captures cognitive processing than static methods and reveals network measurement linked to task performance and psychopathology that offer precise neural markers for mental health risks.

Flooding threatens urban economies via direct damages and supply-chain disruptions. Losses grow nonlinearly: wealthier cities incur larger absolute losses, while poorer cities face higher relative impacts, highlighting tailored resilience measures.

Sabatino and colleagues examine expanded CD8⁺ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus, suggesting EBV reactivation may drive pathogenesis in these patients.

Genome-wide analyses in the Norwegian HUNT study with replication in Swedish and Finnish cohorts identify host genetic variants associated with gut microbiome features and provide evidence of a causal effect of body mass index on gut microbiota composition.

Biogenic–anthropogenic interactions increase the formation and prevalence of secondary organic aerosol coatings on urban black carbon in Nanjing, China. These coatings amplify radiative effects, according to a model–data analysis for 2023.

Cell-free DNA is widely used in clinical testing, but its genetic basis remains unclear. Here, the authors perform cfGWAS in 28,016 pregnant women, identifying 15 loci linked to cfDNA end motifs and confirming roles for neutrophils through validation studies.

Snow droughts are periods of unusually low snowpack driven by warming winters and reduced snowfall in regions that rely on snow. This study shows that the frequency of snow drought events increased by 5.3–6.7% per decade from 1960 to 2020 in global winter wheat croplands, and that winter wheat yield sensitivity to snow droughts has intensified in 25% of Northern Hemisphere croplands.

A new species of pantylid microsaur from the Late Carboniferous of Cape Breton Island, Nova Scotia, has teeth with dental occlusion consistent with herbivory, indicating an early transition to this condition among terrestrial tetrapods.

The isolation of catenated nitrogen compounds is difficult, in part because these chains can readily lose nitrogen, creating a strong thermodynamic push towards decomposition. Now, a series of molecules containing radical anions of four-atom nitrogen chains have been synthesized and studied under ambient conditions; the chain can cleave into N1 and N3 fragments, and can act as a source of nitrene radical anion.

Plasmacytoid dendritic cells produce type I interferons in response to viral sensing. Here the authors show that amines inhibit these plasmacytoid dendritic cell responses through CXCR4 engagement.

In a study of four brain-dead human decedents, extracorporeal liver cross-circulation using genetically modified pig livers provides essential hepatic functions, supporting the feasibility of this approach for temporary liver support as a bridge to organ transplantation.

Conventional methods for human motion analysis using sensors tightly attached to the body are often uncomfortable. Here, the authors demonstrate motion recognition and prediction using sensors embedded in garments. The results provide guidance for the development of wearable technology integrated into everyday clothing.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Pangenomic and epidemiological analyses reveal a genetic shift in U.S. Salmonella Hadar populations during 2019–20, driven by expansion of a lineage carrying a prophage-like element that likely arose in commercial poultry and spread to backyard flocks.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

The HIV-1 RNA-binding protein rev facilitates nuclear export of viral RNA. Here, the authors use native mass spectrometry to study the interactions between rev-derived peptides and rev response elements of HIV-1 RNA, providing mechanistic insights into rev recognition and recruitment.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

The role of normally silenced transposable elements (TEs) in tumorigenesis remains unclear. Here, the authors show that increased expression of TEs in both patients and mice with colitis or by DNA hypomethylating drugs elicits a viral mimicry response that suppresses tumorigenesis. This viral mimicry response inhibits the stemness of cancer initiating cells in a cell autonomous manner.

Here the authors spatially map tuberculosis granulomas from nonhuman primates to link structure and immune organization with bacterial control. They find that a conserved hypoxic myeloid core is associated with dysfunctional immunity, restricted lymphocyte access and increased bacterial burden.

Application of multiancestry and ensemble-based approaches yields improved polygenic risk prediction models for breast cancer and its subtypes among women of African ancestry.

Producing valuable hydrocarbons electrochemically from carbon monoxide (CO) is an energy-efficient pathway, but reliance on costly pure CO as a feedstock limits its economic viability. This article shows that abundant CO-rich syngas can be directly used to synthesize ethylene.

Saccadic eye movements during free viewing exhibit patterns that reflect a strategy to increase neural responses by matching motor behavior with the statistics of the natural world and with the processing limitations of sensory systems.

This study detects Chlamydia pneumoniae in human retina and brain, increasing with AD severity. Retinal pathogen load with Aβ₄₂ may predict AD stage. In models, infection drives Aβ deposition and NLRP3 activation, worsening pathology and cognition.

Juno radio occultations precisely redefine Jupiter’s shape, measuring a polar diameter of 66,842 km and an equatorial diameter of 71,488 km, both smaller than long-used values, bringing models of the planet’s interior into better agreement with observations.

Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibitors in mixed-lineage leukaemia.

Energy deposition inside silicon with ultrashort laser pulses is intrinsically restricted. Here, authors demonstrate that this filamentation-driven ceiling is universal in semiconductors. Extreme nonlinearities are quantified to predict and optimize involume laser-semiconductor interaction.

The authors describe the discovery of a series of potent non-competitive allosteric inhibitors of the ZIKV NS2B-NS3 protease, which exhibit antiviral activity in vitro and robust oral efficacy against ZIKV infections in a mouse model.

Spatiotemporal insight into photoactivation of the prototypical B₁₂ photoreceptor CarH is revealed across nine orders of magnitude in time, identifying a transient adduct that distinguishes it from thermally activated B₁₂ enzymes.

González-Gualda, Reinius et al. demonstrate that platinum-based chemotherapy-induced senescence promotes malignancy in ovarian and lung cancer via TGFβ ligands, with evidence in mouse models validated in clinical samples. Concomitantly blocking TGFβ signaling with chemotherapy reduces tumor burden and increases survival in mice.

An anti-HIV-1 antibody that targets an N332_gp120 glycan-independent V3 epitope, a site of Env vulnerability, can decline viremia in HIV-1-infected humanized mice while overcoming classical V3 escape mutations.

PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.

Using a regioirregular polymerization strategy, diverse polymer structures containing urethane, carbonate and urea linkages are synthesized from a single tetramethylene urethane monomer. Mixed polymers can be depolymerized to the starting monomer in a closed-loop manner.

The Akt-mTOR axis influences cell activation, differentiation and metabolism. Jordan and colleagues show that thymic and inducible T_H17 cells exhibit different requirements for mTORC1 and mTORC2 as well as Akt isoforms.

Earth’s core dynamo, which produces the magnetic field, may have been influenced by spatial variations in heat flux across the core–mantle boundary, according to combined palaeomagnetic datasets and geodynamo simulations.