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Showing 1–17 of 17 results
Advanced filters: Author: S. Massberg Clear advanced filters

  • During sterile inflammation, emigrating leukocytes sequentially engage subsets of pericytes associated with blood vessels and acquire adhesive, migratory and survival signals.

    • Ronen Alon
    • Sussan Nourshargh
    News & Views
    Nature Immunology
    Volume: 14, P: 14-15

  • Premature infants can suffer from an anatomical defect in which the ductus arteriosus, a blood vessel that connects the pulmonary artery and the aorta during fetal development, fails to close at birth. Katrin Echtler et al. now show that platelets are needed for closure in mice and that reduced platelet function may be clinically relevant: in a retrospective study of preterm human infants, low platelet counts were associated with the presence of an unclosed ductus arteriosus.

    • Katrin Echtler
    • Konstantin Stark
    • Steffen Massberg
    Research
    Nature Medicine
    Volume: 16, P: 75-82

  • Thrombosis is the most frequent cause of mortality worldwide. In this Review, the authors propose that thrombosis might also have a conserved physiological role in immune defence via a process termed immunothrombosis. However, if uncontrolled, immunothrombosis facilitates pathological clot formation.

    • Bernd Engelmann
    • Steffen Massberg
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 34-45

  • Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating monocytes are recruited to maintain homeostasis, while arterial macrophages of yolk sac origin carry out tissue repair.

    • Tobias Weinberger
    • Dena Esfandyari
    • Christian Schulz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Metabolomics analyses reported an increased risk of cardiovascular disease associated with the artificial sweetener erythritol, supported by mechanistic studies showing that high levels of erythritol enhanced platelet reactivity and thrombosis formation.

    • Marco Witkowski
    • Ina Nemet
    • Stanley L. Hazen
    Research
    Nature Medicine
    Volume: 29, P: 710-718

  • Tissue-resident macrophages are derived from yolk sac progenitors but how and when these progenitors enter is unclear. Here the authors use fate mapping and intravital microscopy to track the movement of resident macrophage precursors from the yolk sac to fetal tissues during development.

    • C. Stremmel
    • R. Schuchert
    • C. Schulz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Cathelicidins are antimicrobial peptides that eliminate pathogens and contribute to the innate immune response. Here the authors show that neutrophil-derived LL-37/CRAMP induces platelet activation and promotes arterial thrombosis and thrombo-inflammation.

    • Joachim Pircher
    • Thomas Czermak
    • Christian Schulz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Zekavat, Matesanz, Viana-Huete et al. show an increased risk of peripheral artery disease and atherosclerosis in different vascular beds in patients with clonal hematopoiesis of indeterminate potential (CHIP) caused by mutations in DNA damage repair genes, such as TP53. Validations in a mouse model support the causal contribution of TP53-mutant CHIP to atherosclerosis.

    • Seyedeh M. Zekavat
    • Vanesa Viana-Huete
    • Derek Klarin
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 144-158

  • In this Perspectives article, the authors highlight what is known about cardiovascular sequelae in survivors of COVID-19 and discuss important questions that need to be addressed in prospective studies to understand and mitigate these lasting cardiovascular consequences, including in post-acute COVID-19 syndrome.

    • Benjamin A. Satterfield
    • Deepak L. Bhatt
    • Bernard J. Gersh
    Reviews
    Nature Reviews Cardiology
    Volume: 19, P: 332-341

  • In addition to their well-established role in haemostasis, platelets also have an active role in the immune response. Here the authors summarize the evidence linking platelet activation to immune dysregulation and organ damage in immune-mediated inflammatory diseases, and discuss the therapeutic potential of targeting platelets.

    • Marc Scherlinger
    • Christophe Richez
    • Patrick Blanco
    Reviews
    Nature Reviews Immunology
    Volume: 23, P: 495-510