Nature Search

Accumulation of eight heavy metals in water chestnut (Trapa natans L.) of four major water bodies of Jammu and Kashmir, India

Mohssen Elbagory
Faizah Amer Altihani
Pankaj Kumar
ResearchOpen Access19 Feb 2026
Scientific Reports

Volume: 16, P: 1-15
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Circadian rhythm profiles derived from accelerometer measures of the sleep-wake cycle in two cohort studies

Accelerometers measures multiple dimensions of circadian rhythm but studies tend to examine these dimensions separately. Here, the authors show this might be an oversimplification, as demonstrated by the nine identified clusters related to rest-activity rhythm, daytime activity, sleep, and chronotype.

Sam Vidil
Ian Meneghel Danilevicz
Séverine Sabia
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 16, P: 1-14
Active Relaxation of Unstriated Muscle

SUNITA INDERJIT SINGH
INDERJIT SINGH
Research14 Oct 1950
Nature

Volume: 166, P: 647
Development of fuzzy-based ranking alternatives by hybrid RSM-fuzzy AHP-fuzzy CoCoSo framework sustainable ultrasonic-assisted turning of magnesium alloys

S. P. Sundar Singh Sivam
V. G. Umasekar
Adebayo Samuel Olabisi
ResearchOpen Access09 Jan 2026
Scientific Reports

Volume: 16, P: 1-26
Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

Shilpa Singh
Catherine E. Gleason
Matthew G. Oser
ResearchOpen Access20 Aug 2025
Nature

Volume: 646, P: 734-745
Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction

Multi-ancestry genome-wide and transcriptome-wide association studies of aortic stenosis identify more than 200 independent risk loci and provide insights into its genetic architecture.

Aeron M. Small
Ta-Yu Yang
George Thanassoulis
ResearchOpen Access19 Dec 2025
Nature Genetics

Volume: 58, P: 57-66
A food system transformation pathway reconciles 1.5 °C global warming with improved health, environment and social inclusion

This study applies a global food and land system modelling framework to quantify the impact of 23 food system measures on 15 outcome indicators related to public health, the environment, social inclusion and the economy—from today until 2050.

Benjamin Leon Bodirsky
Felicitas Beier
Alexander Popp
ResearchOpen Access19 Dec 2025
Nature Food

Volume: 6, P: 1133-1152
Identification of MHC Class II Binders/ Non-binders using Negative Selection Algorithm

S.S. Soam
Feroz Khan
B. N. Mishra
ResearchOpen Access16 Nov 2011
Nature Precedings

P: 1
Microbial signals in primary and metastatic brain tumors

A combination of high-resolution spatial imaging, spatial proteomics and transcriptional data reveals sparse and heterogeneous bacterial signals in gliomas and brain metastases.

Golnaz Morad
Ashish V. Damania
Jennifer A. Wargo
ResearchOpen Access14 Nov 2025
Nature Medicine

Volume: 31, P: 3675-3688
A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons

Prabhati Ray
Bal Ram Singh
Michael Adler
ResearchOpen Access13 Aug 2008
Nature Precedings

P: 1
Pressure-tuned plethora of ferroelectric phases in CuInP₂S₆

Sambridhi Shah
Pegah Mohammadi
Janice L. Musfeldt
ResearchOpen Access17 Jan 2026
npj 2D Materials and Applications

P: 1-10
An ER-resident lipid scramblase is crucial for biogenesis and function of apicomplexan parasite secretory organelles

The authors identify the DedA superfamily protein VMP1 as an ER-resident lipid transporter in human parasites T. gondii and P. falciparum. VMP1 is crucial for the function of secretory organelles, ER maintenance, and homeostasis of lipid droplets.

G. Srinivas Reddy
Somesh M. Gorde
Puran Singh Sijwali
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 16, P: 1-25
Is REST a regulator of pluripotency?

Noel J. Buckley
Rory Johnson
Lawrence W. Stanton
Research26 Feb 2009
Nature

Volume: 457, P: E5-E6
Correlates of HIV-1 control after combination immunotherapy

Combination immunotherapy approaches might be effective in inducing sustained control of HIV by slowing rebound and improving CD8⁺ T cell responses.

M. J. Peluso
D. A. Sandel
R. L. Rutishauser
ResearchOpen Access01 Dec 2025
Nature

Volume: 650, P: 187-195
Concurrent TB and HIV therapies control TB reactivation during co-infection but not chronic immune activation

The basis for inefficient Mtb control in PLWH despite treatment is unclear. Here, the authors show that combined TB/HIV therapy in Mtb/SIV co-infected macaques reduces bacterial and viral burden and improved lung pathology, but failed to fully restore immune balance, revealing persistent inflammation.

Riti Sharan
Yi Zou
Deepak Kaushal
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 17, P: 1-16
Contractile Systems of Unstriated Muscle

SUNITA INDERJIT SINGH
INDERJIT SINGH
Research07 Apr 1951
Nature

Volume: 167, P: 564
Sleep deprivation disrupts lacrimal gland homeostasis via hypothalamic-pituitary-adrenal axis and gut dysbiosis in mice

Sleep deprivation disrupts the HPA–gut microbiome axis, depleting SCFAs and triggering IL-17–driven lacrimal gland inflammation in mice. Pharmacological HPA inhibition and microbiome-based interventions restore immune balance and gland homeostasis.

Shenzhen Huang
Shufan Yu
Zhijie Li
ResearchOpen Access06 Feb 2026
Communications Biology

P: 1-18
Glycolipid recognition and binding by Siglec-6 hinges on interactions with the cell membrane

Siglecs are immunoregulatory lectins with very similar architectures. The authors show how the V-set domain of Siglec-6 allows it to select for precise sialylation patterns in specific biological environments, recasting Siglecs as molecular precision tools

Silvia D’Andrea
Edward N. Schmidt
Elisa Fadda
ResearchOpen Access28 Jan 2026
Communications Biology

P: 1-13
Be⁺ assisted, simultaneous confinement of more than 15000 antihydrogen atoms

Antimatter remains an enigma – its absence in the universe is hitherto unexplained. Here, the authors report a breakthrough in the ability to study antihydrogen atoms to test fundamental symmetries. Antihydrogen atoms can now be accumulated at CERN at the previously unattainable rate of 2000 per hour.

R. Akbari
L. O. de Araujo Azevedo
J. S. Wurtele
ResearchOpen Access18 Nov 2025
Nature Communications

Volume: 16, P: 1-11
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull

Amare Eshetu Gemeda
Mahak Singh
S. K. Ghosh
ResearchOpen Access03 Feb 2026
Scientific Reports

Volume: 16, P: 1-16
Unveiling causal regulatory mechanisms through cell-state parallax

Single-cell multimodal data has the potential to unveil noncoding disease mechanisms. Here, authors introduce GrID-Net, a graph-based Granger causal approach that links noncoding variants to genes by exploiting the time lag between epigenomic and transcriptional cell states.

Alexander P. Wu
Rohit Singh
Bonnie Berger
ResearchOpen Access29 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Structure of a human Clara cell phospholipid-binding protein–ligand complex at 1. 9 Å resolution

Timothy C. Umland
S. Swaminathan
Martin Sax
Research01 Aug 1994
Nature Structural Biology

Volume: 1, P: 538-545
Sterile protection of monkeys against malaria after administration of interleukin-12

S.L. Hoffman
J.M. Crutcher
M. Sedegah
Research01 Jan 1997
Nature Medicine

Volume: 3, P: 80-83
Multi-omic profiling reveals age-related immune dynamics in healthy adults

This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes with age, including responses to cytomegalovirus infection and influenza vaccination.

Qiuyu Gong
Mehul Sharma
Claire E. Gustafson
ResearchOpen Access29 Oct 2025
Nature

Volume: 648, P: 696-706
Automation and machine learning drive rapid optimization of isoprenol production in Pseudomonas putida

Laboratory automation, machine learning, and metabolic engineering may be combined to quickly and efficiently build productive microbial strains. Here the authors used these techniques in P. putida to boost isoprenol titers 5-fold over six DBTL cycles while sampling a reduced design space.

David N. Carruthers
Patrick C. Kinnunen
Taek Soon Lee
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 16, P: 1-16
Isolation of new racemic sugar (D/L galacturonic acid) from leaves of Paederia foetida Linn.

Vikas Kumar
Yadav Pankajkumar S
Md. Ali
ResearchOpen Access01 Mar 2011
Nature Precedings

P: 1
Chemical Synthesis of Porphobilinogen: Initiation of Explosion by Light and by Flying Fragments

J. S. COURTNEY-PRATT
G. T. ROGERS
Research09 Apr 1955
Nature

Volume: 175, P: 632-633
Translational genomics of osteoarthritis in 1,962,069 individuals

A genome-wide association study meta-analysis combined with multiomics data of osteoarthritis identifies 700 effector genes as well as biological processes with a convergent involvement of multiple effector genes; 10% of these genes express the target of approved drugs.

Konstantinos Hatzikotoulas
Lorraine Southam
Eleftheria Zeggini
ResearchOpen Access09 Apr 2025
Nature

Volume: 641, P: 1217-1224
Divergent transcriptional regulation of redox-homeostasis and permeability modulate rifampicin tolerance and sensitivity in Mycobacterium tuberculosis

Drug tolerance can delay treatment response to Mycobacterium tuberculosis infection. Here, the authors identify transcription factors and their effector genes that impact tolerance and hypersusceptibility and may serve as potential new drug targets.

Jees Sebastian
Shuyi Ma
David Alland
ResearchOpen Access14 Dec 2025
Nature Communications

Volume: 17, P: 1-15
Generation and Analysis of Ultrasonic Noise

S. C. GHOSE
Research14 Jan 1950
Nature

Volume: 165, P: 66-67
Dramatic expansion of bimodal redox window of indigo by two-electron redox processes

Indigo is an extremely popular molecule in dye industry, however, its use in photochemical transformations is surprisingly scarce. This report explores its photocatalytic activity over an unusually wide excited-state redox window.

Monojit Roy
Shyamali Maji
Debashis Adhikari
ResearchOpen Access16 Dec 2025
Nature Communications

Volume: 16, P: 1-9
Experimental investigation and optimization of mechanical and tribological performances of bio-based sustainable hybrid composites incorporating Nano-SiO₂ fillers

G. Velmurugan
Jasgurpreet Singh Chohan
Mukesh Kumar
ResearchOpen Access04 Feb 2026
Scientific Reports

Volume: 16, P: 1-26
A temperature- and impedance-aware LSTM–PINN framework for physically consistent battery SOH prediction

Prajakth N. Kumar
Praneeth R. Upadhya
Rashmi K. B.
ResearchOpen Access06 Feb 2026
Scientific Reports

Volume: 16, P: 1-11
Rhenium adsorption from an organic impurity–containing solution

Svetlana Yefremova
Askhat Kablanbekov
ResearchOpen Access05 Feb 2026
Scientific Reports

Volume: 16, P: 1-18
Intrathecal onasemnogene abeparvovec in treatment-naive patients with spinal muscular atrophy: a phase 3, randomized controlled trial

The phase 3 STEER trial showed that a single intrathecal dose of onasemnogene abeparvovec significantly improved motor function in children and adolescents with spinal muscular atrophy versus sham, with a similar and acceptable safety profile.

Crystal M. Proud
Dũng Chí Vũ
Yuh-Jyh Jong
ResearchOpen Access08 Dec 2025
Nature Medicine

Volume: 32, P: 481-487
Heparin and Blood Lipids in Fasted Individuals

A. N. GRANITSAS
A. S. ACHIMASTOS
Research13 Oct 1962
Nature

Volume: 196, P: 173-174
Energy-efficient strategies for maize-safflower cropping systems: comparative analysis of tillage and weed management practices

Kasa Kiran Kumar Reddy
K. P. Vani
L. Peace Raising
ResearchOpen Access11 Nov 2025
Scientific Reports

Volume: 15, P: 1-15
SBTM: epileptic seizure prediction from EEG signal using deep learning in blockchain-enabled smart healthcare monitoring with IoT networking

Abhishek Kumar
Esha Tripathi
Arshiya S. Ansari
ResearchOpen Access31 Jan 2026
Scientific Reports

Volume: 16, P: 1-28
Vacuolar-type H⁺-ATPase-mediated extra-organellar buffering resolves mitochondrial dysfunction

Mitochondrial dysfunction underlies a multitude of human diseases. Here, the authors show that partial inhibition of the vacuolar-type H⁺-ATPase enhances cell fitness under mitochondrial stress.

Geoffray Monteuuis
Ryan Awadhpersad
Christopher B. Jackson
ResearchOpen Access03 Dec 2025
Nature Communications

Volume: 17, P: 1-16
Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

Here authors show loss of AKAP11, a strong genetic risk factor for bipolar disorder and schizophrenia, disrupts PKA proteostasis and signaling, leading to widespread transcriptomic alterations across the brain, particularly in striatal neurons, as well as altered behavior.

Bryan J. Song
Yang Ge
Morgan Sheng
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-25
Torsion is a dynamic regulator of DNA replication stalling and reactivation

DNA replication generates torsional stress. Here, the authors found the T7 replisome to be a powerful rotary motor. Helicase-DNA polymerase interactions stabilize stalled forks, enabling restart after gyrase torsional relaxation, highlighting torsion as a key regulator of replication.

Xiaomeng Jia
Xiang Gao
Michelle D. Wang
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Nutrient release in leaf litter

A. S. RAGHUBANSHI
S. C. SRIVASTAVA
J. S. SINGH
Research19 Jul 1990
Nature

Volume: 346, P: 227
Direct introgression of untapped diversity into elite wheat lines

Ancestral wheat relatives can enrich the genetic diversity of modern cultivars and contribute to stress adaptation. A meta-genome-wide association study identifies the exotic genome footprints in a wheat pre-breeding population, as well as some exotic-specific agronomic traits.

Sukhwinder Singh
A. Jighly
N. S. Bains
Research07 Oct 2021
Nature Food

Volume: 2, P: 819-827
A place-based assessment of biodiversity intactness in sub-Saharan Africa

Regional, place-based biodiversity information is used to comprehensively map and quantify biodiversity intactness of sub-Saharan Africa to inform national and global sustainability policies and planning.

Hayley S. Clements
Reinette Biggs
Andrew L. Skowno
ResearchOpen Access03 Dec 2025
Nature

Volume: 649, P: 113-121
A nickel gallium oxide chlorophyll mimic for green methanol synthesis

Here the authors report NiGa₂O_4–x(OH)_y for light-driven CO₂ hydrogenation to methanol. The surface Lewis acid–base pairs and -OH groups act as conduits for H^- /H⁺ transport to active sites, enhancing photocatalytic methanol production.

Rui Song
Zhiwen Chen
Geoffrey A. Ozin
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-14
SH3 domains selectively activate the PI3 kinase through non-conventional tertiary contacts

Structural and functional analysis shows that only SH3 domains forming tertiary contacts with p85 release p110 inhibition, revealing a binding-mode–based selection mechanism that ensures specific activation of PI3K.

Safia S. Aljedani
Anandsukeerthi Sandholu
Stefan T. Arold
ResearchOpen Access19 Jan 2026
Communications Biology

P: 1-18
Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial

To address an evidence gap for the efficacy of hypertension therapy using dual drug combinations in patients of South Asian origin, a randomized clinical trial conducted in India found that three types of dual drug combinations, each administered in a single pill, had similarly large effects on reducing blood pressure.

Dorairaj Prabhakaran
Ambuj Roy
Neil R. Poulter
ResearchOpen Access25 Jul 2025
Nature Medicine

Volume: 31, P: 3169-3175
Structure of Rhombohedral 2 Zinc Insulin Crystals

M. J. ADAMS
T. L. BLUNDELL
S. SHEAT
Research01 Nov 1969
Nature

Volume: 224, P: 491-495
Regional variation in fruitflies

Rama S. Singh
Larry R. Hale
Research09 Jun 1994
Nature

Volume: 369, P: 450

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