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Showing 101–150 of 316 results

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Expression of peroxisome proliferator-activated receptor (PPAR)γ in gastric cancer and inhibitory effects of PPARγ agonists

H Sato
S Ishihara
Y Kinoshita
ResearchOpen Access24 Oct 2000
British Journal of Cancer

Volume: 83, P: 1394-1400
Mathematical models for the evolution of multigene families by unequal crossing over

Alan S. Perelson
George. I. Bell
Research27 Jan 1977
Nature

Volume: 265, P: 304-310
Evolution of the Altaid tectonic collage and Palaeozoic crustal growth in Eurasia

A. M. C. Şengör
B. A. Natal'in
V. S. Burtman
Research22 Jul 1993
Nature

Volume: 364, P: 299-307
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

Sven Enerbäck
Anders Jacobsson
Leslie P. Kozak
Research01 May 1997
Nature

Volume: 387, P: 90-94
Identification and processing of proglucagon in pancreatic islets

C. Patzelt
H. S. Tager
D. F. Steiner
Research15 Nov 1979
Nature

Volume: 282, P: 260-266
Biochemistry of Heredity: A General Hypothesis

IAN LESLIE
Research28 Jan 1961
Nature

Volume: 189, P: 260-268
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

Blocking ERK/MAP kinases improves insulin sensitivity thorough a mechanism similar to the actions of the anti-diabetic thiazolidinediones drugs on PPARγ.

Alexander S. Banks
Fiona E. McAllister
Bruce M. Spiegelman
Research17 Nov 2014
Nature

Volume: 517, P: 391-395
Human leptin levels are pulsatile and inversely related to pituitary–ardenal function

Julio Licinio
Christos Mantzoros
Philip W. Gold
Research01 May 1997
Nature Medicine

Volume: 3, P: 575-579
Determination of the Helical Configuration of Ribonucleic Acid Molecules by X-Ray Diffraction Study of Crystalline Amino-Acid–transfer Ribonucleic Acid

M. SPENCER
W. FULLER
G. L. BROWN
Research16 Jun 1962
Nature

Volume: 194, P: 1014-1020
Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

Evidence from mice and humans indicates that peripartum cardiomyopathy (PPCM) is a vascular disease caused by excessive anti-angiogenic signalling in the peripartum period of pregnancy and that pre-eclampsia and multiple gestation are important risk factors for the development of PPCM.

Ian S. Patten
Sarosh Rana
Zoltan Arany
Research09 May 2012
Nature

Volume: 485, P: 333-338
Boström et al. reply

Pontus Boström
Jun Wu
Bruce M. Spiegelman
Research29 Aug 2012
Nature

Volume: 488, P: E10-E11
Is there a local source of magnetic monopoles?

S. Dimopoulos
S. L. Glashow
F. Wilczek
Research26 Aug 1982
Nature

Volume: 298, P: 824-825
A Symposium on the Use of Isotopes in Biology and Medicine Advances in Biological and Medical Physics Radioactive Indicators

A. S. MCFARLANE
Books & Arts26 Feb 1949
Nature

Volume: 163, P: 303-304
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Wei and colleagues report that phosphorylation of Sin1 by S6K or Akt results in its dissociation from mTORC2, thus suppressing mTORC2 activity. A cancer-patient-derived Sin1 mutation that impairs this phosphorylation leads to mTORC2 hyperactivation and increased tumour formation in mice.

Pengda Liu
Wenjian Gan
Wenyi Wei
Research27 Oct 2013
Nature Cell Biology

Volume: 15, P: 1340-1350
Transcriptional activation of c-jun during the G₀/G₁ transition in mouse fibroblasts

R.-P. Ryseck
S. I. Hirai
R. Bravo
Research01 Aug 1988
Nature

Volume: 334, P: 535-537
Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice

Andreas M. Reimold
Michael J. Grusby
Laurie H. Glimcher
Research18 Jan 1996
Nature

Volume: 379, P: 262-265
Infectious primate type-C virus shed by healthy gibbons

THOMAS G. KAWAKAMI
LILY SUN
TERRY S. McDOWELL
Research04 Aug 1977
Nature

Volume: 268, P: 448-450
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

Robert S. Jackson
John W.M. Creemers
Stephen O'Rahilly
Research01 Jul 1997
Nature Genetics

Volume: 16, P: 303-306
Trade-offs between life-history traits and a secondary sexual character in male collared flycatchers

Lars Gustafsson
Anna Qvarnström
Ben C. Sheldon
Research25 May 1995
Nature

Volume: 375, P: 311-313
Compositions of near-solidus peridotite melts from experiments and thermodynamic calculations

M. B. Baker
M. M. Hirschmann
E. M. Stolper
Research25 May 1995
Nature

Volume: 375, P: 308-311
Detection of DNA complementary to pathogenic viroid RNA in exocortis disease

J. S. SEMANCIK
J. L. M. C. GEELEN
Research28 Aug 1975
Nature

Volume: 256, P: 753-756
Presence of antibody to a primate RNA virus in human plasma

BYUNG S. KIM
Research16 Oct 1975
Nature

Volume: 257, P: 614-616
Role of the Vagus Nerve in the Control of the Concentration of Angiotensin II in the Circulation

R. L. HODGE
R. D. LOWE
J. R. VANE
Research11 Jan 1969
Nature

Volume: 221, P: 177-179
Thyroid hormone receptor α isoforms generated by alternative splicing differentially activate myosin HC gene transcription

Seigo Izumo
Vijak Mahdavi
Research01 Aug 1988
Nature

Volume: 334, P: 539-542
Absence of Messenger RNA for Beta Globin Chain in β°-Thalassaemia

B. G. FORGET
E. J. BENZ JUN
D. HOUSMAN
Research08 Feb 1974
Nature

Volume: 247, P: 379-381
Homology between human breast tumour RNA and mouse mammary tumour virus genome

AKHIL B. VAIDYA
MAURICE M. BLACK
DAN H. MOORE
Research07 Jun 1974
Nature

Volume: 249, P: 565-567
Mutagenic Methods for determining which DNA Strand is transcribed for Individual Viral Genes

ANNE S. VANDERBILT
IRWIN TESSMAN
Research03 Oct 1970
Nature

Volume: 228, P: 54-56
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

Bradford B. Lowell
Vedrana S-Susulic
Jeffrey S. Flier
Research30 Dec 1993
Nature

Volume: 366, P: 740-742
Fibronectin inhibits the terminal differentiation of human keratinocytes

Josephine C. Adams
Fiona M. Watt
Research27 Jul 1989
Nature

Volume: 340, P: 307-309
Ribosomal DNA Connectives between Human Acrocentric Chromosomes

A. S. HENDERSON
D. WARBURTON
K. C. ATWOOD
Research14 Sept 1973
Nature

Volume: 245, P: 95-97
Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

Tony Kouzarides
Edward Ziff
Research17 Aug 1989
Nature

Volume: 340, P: 568-571
In vitro assembly of 30S ribosomal particles from precursor 16S RNA of Escherichia coli

JOHN W. WIREMAN
PAUL S. SYPHERD
Research22 Feb 1974
Nature

Volume: 247, P: 552-554
In vitro Inhibition of Peptide Synthesis and GTP Hydrolysis by Cycloheximide and Reversal of Inhibition by Glutathione

H. N. MUNRO
B. S. BALIGA
A. W. PRONCZUK
Research31 Aug 1968
Nature

Volume: 219, P: 944-946
Haemoglobin Initiation in Protein Synthesis by Animal Cells and the Universality of the Genetic Code

H. R. V. ARNSTEIN
HANNAH RAHAMIMOFF
Research31 Aug 1968
Nature

Volume: 219, P: 942-944
Evidence for a ‘mammalian’ thyroglobulin in endostyle of the ascidian Styela clava

MICHAEL C. THORNDYKE
Research01 Jan 1978
Nature

Volume: 271, P: 61-62
Seismic evidence for silicate melt atop the 410-km mantle discontinuity

J. Revenaugh
S. A. Sipkin
Research09 Jun 1994
Nature

Volume: 369, P: 474-476
Polymeric fullerene chains in RbC₆₀ and KC₆₀

Peter W. Stephens
G. Bortel
L. Forró
Research25 Aug 1994
Nature

Volume: 370, P: 636-639
Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine

Tissue nonspecific alkaline phosphatase (TNAP) within mitochondria hydrolyses phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation in thermogenic fat cells.

Yizhi Sun
Janane F. Rahbani
Bruce M. Spiegelman
Research12 May 2021
Nature

Volume: 593, P: 580-585
CRD-BP mediates stabilization of βTrCP1 and c-myc mRNA in response to β-catenin signalling

β-catenin stabilizes the mRNA encoding the F-box protein βTrCP1, and the RNA-binding protein CRD–BP (coding region determinant-binding protein) is identified as a previously unknown target of β-catenin/Tcf transcription factor.

Felicite K. Noubissi
Irina Elcheva
Vladimir S. Spiegelman
Research15 Jun 2006
Nature

Volume: 441, P: 898-901
Trade-off in production between adjacent seamount chains near the East Pacific Rise

Yang Shen
Daniel S. Scheirer
Ken C. Macdonald
Research12 Jan 1995
Nature

Volume: 373, P: 140-143
Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance

S E Shoelson
J Lee
M Yuan
Research14 Nov 2003
International Journal of Obesity

Volume: 27, P: S49-S52
Overexpression of mRNA-binding protein CRD-BP in malignant melanomas

I Elcheva
R S Tarapore
V S Spiegelman
Research05 May 2008
Oncogene

Volume: 27, P: 5069-5074
Oncogenic BRAF regulates β-Trcp expression and NF-κB activity in human melanoma cells

J Liu
K G Suresh Kumar
S Y Fuchs
Research25 Sept 2006
Oncogene

Volume: 26, P: 1954-1958
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

A member of the family of bone morphogenetic proteins, BMP-7, promotes the differentiation of brown, not white, fat cells. BMP-7 switches on regulators of brown fat, among which there is PRDM16, adipogenic transcription factors, and mitochondrial biogenesis. BMP-7 can persuade mesenchymal progenitor cells to become brown adipocytes. Without BMP-7 less brown fat develops.

Yu-Hua Tseng
Efi Kokkotou
C. Ronald Kahn
Research21 Aug 2008
Nature

Volume: 454, P: 1000-1004
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

PPARγ ligands are used to control diabetes, but their anti-diabetic actions are puzzling. Here the authors show that phosphorylation of PPARγ by cyclin-dependent kinase 5 (Cdk5) in mice is linked to obesity induced by high-fat feeding, and that inhibition of the effect in humans by the drug rosiglitazone is closely associated with its anti-diabetic effects. Several anti-diabetic PPARγ ligands directly inhibit the effect, and thus support a more normal non-diabetic pattern of gene expression.

Jang Hyun Choi
Alexander S. Banks
Bruce M. Spiegelman
Research22 Jul 2010
Nature

Volume: 466, P: 451-456
PRDM16 controls a brown fat/skeletal muscle switch

Patrick Seale
Bryan Bjork
Bruce M. Spiegelman
Research21 Aug 2008
Nature

Volume: 454, P: 961-967
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

In mice, expression of PGC1-α in muscles is shown to stimulate expression of FNDC5, which is cleaved and secreted in the circulation as the newly identified hormone irisin; on exercise, this hormone stimulates browning of subcutaneous adipose tissue.

Pontus Boström
Jun Wu
Bruce M. Spiegelman
Research11 Jan 2012
Nature

Volume: 481, P: 463-468
Correction: CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

Stephan Herzig
Fanxin Long
Marc Montminy
Amendments and Corrections11 Oct 2001
Nature

Volume: 413, P: 652
The developing toolkit of continuous directed evolution

This historical Perspective on continuous directed evolution focuses on laboratory approaches that enable greater understanding of evolving molecular populations and offer investigators tools to guide the emergence of new biomolecular systems.

Mary S. Morrison
Christopher J. Podracky
David R. Liu
Reviews22 May 2020
Nature Chemical Biology

Volume: 16, P: 610-619
H⁺ transport is an integral function of the mitochondrial ADP/ATP carrier

The mitochondrial ADP/ATP carrier mediates the proton leak in mitochondria from all tissues that lack UCP1, thereby linking coupled (ATP production) and uncoupled (thermogenesis) energy conversion.

Ambre M. Bertholet
Edward T. Chouchani
Yuriy Kirichok
Research24 Jul 2019
Nature

Volume: 571, P: 515-520

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