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Showing 1–10 of 10 results
Advanced filters: Author: Samantha Zepeda Clear advanced filters

  • Alfajaro et al identify that a bat MERS-like coronavirus HKU5 uses ACE2 as a receptor from its natural bat reservoir Pipistrellus abramus and American mink. Structural analyses demonstrate a unique interaction between the HKU5 receptor binding domain and bat ACE2. This highlights the receptor flexibility of merbecoviruses and identifies mink as potential intermediate hosts, informing viral surveillance and countermeasure development.

    • Mia Madel Alfajaro
    • Emma L. Keeler
    • Craig B. Wilen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • ACE2 binding is an ancestral, widespread trait of sarbecovirus receptor-binding domains, and many single mutations enable binding to different ACE2 receptors.

    • Tyler N. Starr
    • Samantha K. Zepeda
    • Jesse D. Bloom
    ResearchOpen Access
    Nature
    Volume: 603, P: 913-918

  • Pseudovirus assays and surface plasmon resonance show that the Omicron receptor-binding domain binds to human ACE2 with increased affinity relative to the ancestral virus, and that most neutralizing antibodies are considerably less potent against Omicron.

    • Elisabetta Cameroni
    • John E. Bowen
    • Davide Corti
    Research
    Nature
    Volume: 602, P: 664-670

  • The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.

    • Bo Meng
    • Adam Abdullahi
    • Ravindra K. Gupta
    ResearchOpen Access
    Nature
    Volume: 603, P: 706-714

  • The human monoclonal antibody S2X259 cross-reacts with spike proteins from all clades of sarbecovirus, and provides prophylactic and therapeutic protection in vivo against parental SARS-CoV-2 and emerging variants of concern.

    • M. Alejandra Tortorici
    • Nadine Czudnochowski
    • Matteo Samuele Pizzuto
    Research
    Nature
    Volume: 597, P: 103-108

  • Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

    • Andrey Ziyatdinov
    • Jason Torres
    • Roberto Tapia-Conyer
    ResearchOpen Access
    Nature
    Volume: 622, P: 784-793

  • Michael Talkowski and colleagues analyze balanced chromosomal abnormalities in 273 individuals by whole-genome sequencing. Their findings suggest that sequence-level resolution improves prediction of clinical outcomes for balanced rearrangements and provides insight into pathogenic mechanisms such as altered gene regulation due to changes in chromosome topology.

    • Claire Redin
    • Harrison Brand
    • Michael E Talkowski
    Research
    Nature Genetics
    Volume: 49, P: 36-45