TLR4 signaling shifts from plasma membrane TIRAP-MyD88–mediated pathways to endosomal TRAM-TRIF–mediated signaling. Vanhaesebroeck and colleagues show that the kinase PI(3)K p110δ is required for TLR4 internalization and degradation of TIRAP.
- Ezra Aksoy
- Salma Taboubi
- Bart Vanhaesebroeck
