Ataxia telangiectasia mutated (ATM) directly interacts with and phosphorylates the V-ATPase V1 subunit ATP6V1G1, thereby decreasing V1-V0 assembly in the V-ATPase. Attenuation of ATM activity results in lysosomal pH acidification, recovery of autophagy and alleviation of senescence.
- Hyun Tae Kang
- Joon Tae Park
- Sang Chul Park