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Showing 1–12 of 12 results
Advanced filters: Author: Sara E Howden Clear advanced filters

  • Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular human cardiac organoids, enabling modeling of desmoplakin cardiomyopathy dysfunction, which could be rescued using the bromodomain and extra-terminal inhibitor INCB054329.

    • Mark W. Pocock
    • Janice D. Reid
    • James E. Hudson
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 821-840

  • A transcriptional analysis of kidney organoids reveals batch effects as the key drivers of variation, mainly through differences in maturity, and provides a list of highly variable genes and a method for estimating differentiation stage for improved disease modeling.

    • Belinda Phipson
    • Pei X. Er
    • Melissa H. Little
    Research
    Nature Methods
    Volume: 16, P: 79-87

  • Proximal nephron in pluripotent stem cell derived kidney organoids are immature with limited support for functional solute channels. Vanslambrouck et al report improved metanephric specification, generating enhanced kidney organoids with superior proximal tubules, spatially arranged nephrons, and applications for disease research, and drug screening.

    • Jessica M. Vanslambrouck
    • Sean B. Wilson
    • Melissa H. Little
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-23

  • Extrusion-based bioprinting has been shown to rapidly and reproducibly generate kidney organoids from a cell-only paste, with the number and maturation of functional units within the kidney tissue capable of being further improved by bioprinting tissue sheets.

    • Kynan T. Lawlor
    • Jessica M. Vanslambrouck
    • Melissa H. Little
    Research
    Nature Materials
    Volume: 20, P: 260-271

  • A defined and simplified culture system for the derivation and growth of human induced pluripotent stem cells is reported. It permits increased efficiency of human reprogramming with an episomal approach. Also in this issue, Okita et al. describe methods for more efficient episomal reprogramming of human cells.

    • Guokai Chen
    • Daniel R Gulbranson
    • James A Thomson
    Research
    Nature Methods
    Volume: 8, P: 424-429

  • Studies examining human podocytopathies have utilised 2D cultured primary or immortalised podocyte cell lines. Here, the authors demonstrate that 3D human glomeruli sieved from induced pluripotent stem cell-derived kidney organoids retain an improved podocyte identity in vitro facilitating disease modelling and toxicity testing.

    • Lorna J. Hale
    • Sara E. Howden
    • Melissa H. Little
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • This is a one-step protocol for reprogramming and CRISPR/Cas9 gene editing in human fibroblasts, enabling rapid and clonal derivation of multiple gene-targeted iPSC lines.

    • Sara E Howden
    • James A Thomson
    • Melissa H Little
    Protocols
    Nature Protocols
    Volume: 13, P: 875-898

  • A high-quality sequence assembly of the zebrafish genome reveals the largest gene set of any vertebrate and provides information on key genomic features, and comparison to the human reference genome shows that approximately 70% of human protein-coding genes have at least one clear zebrafish orthologue.

    • Kerstin Howe
    • Matthew D. Clark
    • Derek L. Stemple
    ResearchOpen Access
    Nature
    Volume: 496, P: 498-503

  • Studies of lineage relationships in the mouse have advanced the understanding of kidney development and repair. Here, the authors discuss these advances as well as how the application of lineage tools to kidney organoids will facilitate studies of human lineage relationships.

    • Melissa H. Little
    • Sara E. Howden
    • Jessica M. Vanslambrouck
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 8-21