Nature Search

Global potential for natural regeneration in deforested tropical regions

An estimated area of 215 million hectares has the potential for natural forest regeneration across tropical forested countries and biomes, representing an above-ground carbon sequestration potential of 23.4 Gt C.

Brooke A. Williams
Hawthorne L. Beyer
Renato Crouzeilles
ResearchOpen Access30 Oct 2024
Nature

Volume: 636, P: 131-137
IL-17A-producing NKp44(−) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue

Familial adenomatous polyposis (FAP) is an inherited gastrointestinal syndrome associated with duodenal adenoma formation. Here the authors show that IL17A-producing NKp44- group 3 innate lymphoid cells accumulate in FAP duodenal tissue and are associated with duodenal adenoma formation in patients with FAP.

Kim M. Kaiser
Jan Raabe
Jacob Nattermann
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Engineered transcription-associated Cas9 targeting in eukaryotic cells

Cas9 DNA targeting is inherently sequence specific but not temporally controlled. Here, authors spatiotemporally couple Cas9 activity to target site transcription in eukaryotes and exploit this to preferentially edit the more highly transcribed of two alleles that harbor identical Cas9 targets.

Gregory W. Goldberg
Manjunatha Kogenaru
Jef D. Boeke
ResearchOpen Access27 Nov 2024
Nature Communications

Volume: 15, P: 1-19
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Correction: RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer

Derek Dustin
Guowei Gu
Suzanne A. W. Fuqua
Amendments and Corrections01 Sept 2025
British Journal of Cancer

Volume: 133, P: 913-915
Author Correction: Global potential for natural regeneration in deforested tropical regions

Brooke A. Williams
Hawthorne L. Beyer
Renato Crouzeilles
Amendments and CorrectionsOpen Access06 Dec 2024
Nature

Volume: 637, P: E9
PIONEER big data platform for prostate cancer: lessons for advancing future real-world evidence research

PIONEER is a European network of excellence for big data in prostate cancer, which brings together private and public stakeholders from nine countries in one multidisciplinary research consortium. In this Perspectives, members of the consortium detail the achievements of PIONEER and describe its goal of maximizing the potential of big data to improve prostate cancer care in the future.

Ailbhe Lawlor
Katharina Beyer
Ronald Herrera
Reviews09 Sept 2024
Nature Reviews Urology

Volume: 22, P: 116-124
Viral modulation of type II interferon increases T cell adhesion and virus spread

Here, Jacobsen et al show that Varicella zoster virus glycoprotein C binds interferon gamma and induces biased signalling through its receptor, leading to higher expression of adhesion molecules, more T cell adhesion and viral spread from epithelial cells.

Carina Jacobsen
Nina Plückebaum
Abel Viejo-Borbolla
ResearchOpen Access22 Jun 2024
Nature Communications

Volume: 15, P: 1-18
Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

Multi-ancestry genome-wide association analyses identify new risk loci for Parkinson’s disease, and fine-mapping and co-localization analyses implicate candidate genes whose expression is associated with disease susceptibility.

Jonggeol Jeffrey Kim
Dan Vitale
Ignacio Mata
ResearchOpen Access28 Dec 2023
Nature Genetics

Volume: 56, P: 27-36
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy

Food allergy is an increasing public health problem. In a genome-wide scan of children diagnosed by oral food challenge, Marenholz et al. find new genetic associations underlying food allergy, implicating the immune system and the epithelial barrier.

Ingo Marenholz
Sarah Grosche
Young-Ae Lee
ResearchOpen Access20 Oct 2017
Nature Communications

Volume: 8, P: 1-10
Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Gerber, Russ et al. show that the H3.3 chaperone Daxx, which represses endogenous retroviral and retrotransposable elements, acts as an epigenetic barrier to control haematopoietic progenitor plasticity and protect against PU.1-mediated inflammation.

Julia P. Gerber
Jenny Russ
Paolo Salomoni
ResearchOpen Access07 Dec 2021
Nature Cell Biology

Volume: 23, P: 1224-1239
Functional classification of memory CD8⁺ T cells by CX₃CR1 expression

The function of memory CD8⁺ T cells is often believed to be directly correlated with their localization in tissues. Here the authors show that CD8⁺T cells with different proliferative and cytotoxic properties can be distinguished based on their expression of CX3CR1, independently of their tissue localization.

Jan P. Böttcher
Marc Beyer
Percy A. Knolle
ResearchOpen Access25 Sept 2015
Nature Communications

Volume: 6, P: 1-17
Insights into ancestral diversity in Parkinson’s disease risk: a comparative assessment of polygenic risk scores

Paula Saffie-Awad
Spencer M. Grant
Sara Bandres-Ciga
ResearchOpen Access03 Jul 2025
npj Parkinson's Disease

Volume: 11, P: 1-13
Climate-smart ocean planning in small island developing states—exploring pathways in Dominica

Josefa Beyer
Sarah Mahadeo
ResearchOpen Access12 Jul 2025
npj Ocean Sustainability

Volume: 4, P: 1-11
The genetic architecture of human brainstem structures and their involvement in common brain disorders

The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that influence common brain disorders.

Torbjørn Elvsåshagen
Shahram Bahrami
Tobias Kaufmann
ResearchOpen Access11 Aug 2020
Nature Communications

Volume: 11, P: 1-14
The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

Michael Talkowski and colleagues analyze balanced chromosomal abnormalities in 273 individuals by whole-genome sequencing. Their findings suggest that sequence-level resolution improves prediction of clinical outcomes for balanced rearrangements and provides insight into pathogenic mechanisms such as altered gene regulation due to changes in chromosome topology.

Claire Redin
Harrison Brand
Michael E Talkowski
Research14 Nov 2016
Nature Genetics

Volume: 49, P: 36-45
Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.

Xue-Ru Fan
Ye He
Xi-Nian Zuo
ResearchOpen Access05 Aug 2025
Communications Biology

Volume: 8, P: 1-16
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Julia P. Gerber
Jenny Russ
Paolo Salomoni
Amendments and Corrections04 Jan 2022
Nature Cell Biology

Volume: 24, P: 123
Myelin vs Axon Abnormalities in White Matter in Bipolar Disorder

Kathryn E Lewandowski
Dost Ongür
Fei Du
Research20 Nov 2014
Neuropsychopharmacology

Volume: 40, P: 1243-1249
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

Damaged linearized mtDNA needs to be removed from the cell for mitochondrial genome stability. Here the authors shed light into the identity of the machinery responsible for rapidly degrading linearized DNA, implicating the role of mtDNA replication factors.

Viktoriya Peeva
Daniel Blei
Wolfram S. Kunz
ResearchOpen Access30 Apr 2018
Nature Communications

Volume: 9, P: 1-11
Publisher Correction: Common brain disorders are associated with heritable patterns of apparent aging of the brain

Tobias Kaufmann
Dennis van der Meer
Lars T. Westlye
Amendments and Corrections17 Dec 2019
Nature Neuroscience

Volume: 23, P: 295
Common brain disorders are associated with heritable patterns of apparent aging of the brain

Using structural MRI data from 45,615 individuals aged 3–96 years, Kaufmann and colleagues reveal that common brain disorders are associated with heritable patterns of apparent aging of the brain.

Tobias Kaufmann
Dennis van der Meer
Lars T. Westlye
Research24 Sept 2019
Nature Neuroscience

Volume: 22, P: 1617-1623
Neuronal responses in social-emotional information processing in impulsive aggressive individuals

Emil F. Coccaro
Sarah Keedy
K. Luan Phan
Research11 Mar 2022
Neuropsychopharmacology

Volume: 47, P: 1249-1255
Author Correction: Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2)

Lara M. Lange
Micol Avenali
Masharip Atadzhanov
Amendments and CorrectionsOpen Access13 Sept 2023
npj Parkinson's Disease

Volume: 9, P: 1-3
Challenges in large-scale bioinformatics projects

Sarah Morrison-Smith
Christina Boucher
Jaime Ruiz
ResearchOpen Access08 Apr 2022
Humanities and Social Sciences Communications

Volume: 9, P: 1-9
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Amendments and CorrectionsOpen Access17 Mar 2021
Nature

Volume: 592, P: E8
The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population

Lara M. Lange
Kristin Levine
Masharip Atadzhanov
ResearchOpen Access25 Mar 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

Michal Minczuk, Wolfram Kunz and colleagues report that loss-of-function mutations in MGME1 impair mitochondrial DNA replication and cause a multisystemic mitochondrial disease. Their functional studies show that MGME1 encodes a RecB-type exonuclease that cleaves single-stranded DNA and processes DNA flap substrates.

Cornelia Kornblum
Thomas J Nicholls
Holger Prokisch
Research13 Jan 2013
Nature Genetics

Volume: 45, P: 214-219
LifeTime and improving European healthcare through cell-based interceptive medicine

The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Reviews07 Sept 2020
Nature

Volume: 587, P: 377-386
Unanswered questions in prostate cancer — findings of an international multi-stakeholder consensus by the PIONEER consortium

In this Consensus Statement, the authors present results from an international multi-stakeholder consensus conducted by the PIONEER consortium to identify the most important questions in the field of prostate cancer that could be addressed using big data.

Muhammad Imran Omar
Steven MacLennan
Daniel Kotik
Reviews03 Apr 2023
Nature Reviews Urology

Volume: 20, P: 494-501
Discharge protocol in acute pancreatitis: an international survey and cohort analysis

Rita Nagy
Klementina Ocskay
Péter Hegyi
ResearchOpen Access13 Dec 2023
Scientific Reports

Volume: 13, P: 1-10
Targeting senescent cells with NKG2D-CAR T cells

Yushuang Deng
Avadh Kumar
Dan Ehninger
ResearchOpen Access04 May 2024
Cell Death Discovery

Volume: 10, P: 1-14
RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer

Derek Dustin
Guowei Gu
Suzanne A. W. Fuqua
ResearchOpen Access01 Dec 2020
British Journal of Cancer

Volume: 124, P: 191-206
Hormonal modulation of ESR1 mutant metastasis

Guowei Gu
Lin Tian
Suzanne A. W. Fuqua
Research15 Dec 2020
Oncogene

Volume: 40, P: 997-1011
Correction to: Hormonal modulation of ESR1 mutant metastasis

Guowei Gu
Lin Tian
Suzanne A. W. Fuqua
Amendments and Corrections15 Nov 2021
Oncogene

Volume: 41, P: 460
Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer

Asmus Heumann
Özge Kaya
Waldemar Wilczak
ResearchOpen Access17 May 2017
Scientific Reports

Volume: 7, P: 1-10
Low immunogenic endothelial cells endothelialize the Left Ventricular Assist Device

Constanca Figueiredo
Dorothee Eicke
Bettina Wiegmann
ResearchOpen Access05 Aug 2019
Scientific Reports

Volume: 9, P: 1-13
Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Clodagh Towns
Madeleine Richer
Masharip Atadzhanov
ResearchOpen Access12 Sept 2023
npj Parkinson's Disease

Volume: 9, P: 1-6
Trends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021

Nicola L. Barclay
Edward Burn
Danielle Newby
ResearchOpen Access17 Aug 2024
Scientific Reports

Volume: 14, P: 1-16
Author Correction: Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer

Asmus Heumann
Özge Kaya
Waldemar Wilczak
Amendments and CorrectionsOpen Access21 Aug 2018
Scientific Reports

Volume: 8, P: 1-2
A longitudinal resource for population neuroscience of school-age children and adolescents in China

Xue-Ru Fan
Yin-Shan Wang
Xi-Nian Zuo
ResearchOpen Access21 Aug 2023
Scientific Data

Volume: 10, P: 1-24
Embracing model-based designs for dose-finding trials

Sharon B Love
Sarah Brown
Victoria Cornelius
ResearchOpen Access29 Jun 2017
British Journal of Cancer

Volume: 117, P: 332-339

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