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Showing 1–9 of 9 results
Advanced filters: Author: Sarah C. Lowery Clear advanced filters
  • Changes in glycoprotein expression are correlates of disease, but secreted glycoproteins cannot be accurately traced to their cell line of origin. Here, the authors develop a strategy to chemically tag and profile glycoproteins in a cell line-specific manner in co-culture systems and in vivo.

    • Anna Cioce
    • Beatriz Calle
    • Benjamin Schumann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18
  • Pleiotropy is the effect of a single locus on multiple traits, which can lead to undesirable outcomes during crop improvement. Here, the authors reveal regulatory variation controlling pleiotropy between maize leaf angle and tassel branching, two important agronomic traits.

    • Edoardo Bertolini
    • Brian R. Rice
    • Andrea L. Eveland
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • MSK-IMPACT is a clinical sequencing platform able to detect genomic mutations, copy number alterations and structural variants in a panel of cancer-related genes. This assay is implemented prospectively to inform patient enrollment in genomically matched clinical trials at Memorial Sloan Kettering Cancer Center (MSKCC). Sequencing results of tumor and matched normal tissue from a cohort of >10,000 patients with detailed clinical annotation provide an overview of the genomic landscape of advanced solid cancers and bring new insights into molecularly guided cancer therapy.

    • Ahmet Zehir
    • Ryma Benayed
    • Michael F Berger
    Research
    Nature Medicine
    Volume: 23, P: 703-713
  • This is a ductal-dependent lesion and the baby will need prostaglandin infusion to maintain a patent ductus arteriosus to provide systemic blood flow. Given that the lesion is ductal dependent,we would recommend neonatology attendance at delivery with initial stabilization and treatment of the infant in the NEST (Newborn Evaluation, Stabilization, and Treatment Room) with prostaglandin initiation, umbilical line placement and an echocardiogram prior to admission to the PCTU (Pediatric Cardiothoracic ICU). We anticipate that the baby will be stable from a cardiovascular standpoint at delivery and for a short time thereafter as the ductus arteriosus will be open. Initial oxygen saturations above 75% are acceptable for this heart lesion. Therefore, if the baby appears well in the delivery room we would encourage a lot of family a brief period of time for appearance parent-baby bonding either before initial assessment in the NEST or after initial assessment in the NEST and prior to line placement.

    • Ian Thomas
    • Naomi T. Laventhal
    • Sarah Gelehrter
    Research
    Journal of Perinatology
    Volume: 40, P: 1531-1536
  • The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

    • Sanjay Jain
    • Liming Pei
    • Michael P. Snyder
    Reviews
    Nature Cell Biology
    Volume: 25, P: 1089-1100