Nature Search

The response and management of species sensitive to altered fire regimes

In many locations globally, wildfires are becoming more frequent, intense and/or larger in area compared with historical fire regimes. This Review discusses the factors that determine how species and ecosystems respond to changing fire regimes and outlines important conservation and management considerations.

David Lindenmayer
Philip Zylstra
Sarah Legge
Reviews18 Sept 2025
Nature Reviews Biodiversity

P: 1-12
Author Correction: Ex situ seed banks and the IUCN Red List

Sarah E. Dalrymple
Thomas Abeli
Amendments and Corrections08 Aug 2019
Nature Plants

Volume: 5, P: 1022
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

A new GWAS of schizophrenia (11,260 cases and 24,542 controls) and meta-analysis identifies 50 new associated loci and 145 loci in total. The common variant association signal is highly enriched in mutation-intolerant genes and in regions under strong background selection.

Antonio F. Pardiñas
Peter Holmans
James T. R. Walters
Research26 Feb 2018
Nature Genetics

Volume: 50, P: 381-389
c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression.

Wen Jing Sim
Prasanna Vasudevan Iyengar
Jean Paul Thiery
ResearchOpen Access25 Sept 2019
Nature Communications

Volume: 10, P: 1-19
Complement genes contribute sex-biased vulnerability in diverse disorders

Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

Nolan Kamitaki
Aswin Sekar
Steven A. McCarroll
Research11 May 2020
Nature

Volume: 582, P: 577-581
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

Lucia Trastulla
Georgii Dolgalev
Michael J. Ziller
ResearchOpen Access01 Jul 2024
Nature Communications

Volume: 15, P: 1-28
Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

Antonio F. Pardiñas
Peter Holmans
James T. R. Walters
Amendments and Corrections03 Jun 2019
Nature Genetics

Volume: 51, P: 1193
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Research25 Mar 2019
Nature Genetics

Volume: 51, P: 659-674
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

The CNV analysis group of the Psychiatric Genomic Consortium analyzes a large schizophrenia cohort to examine genomic copy number variants (CNVs) and disease risk. They find an enrichment of CNV burden in cases versus controls and identify 8 genome-wide significant loci as well as novel suggestive loci conferring either risk or protection to schizophrenia.

Christian R Marshall
Daniel P Howrigan
Jonathan Sebat
Research21 Nov 2016
Nature Genetics

Volume: 49, P: 27-35
Extraterritorial hunting expeditions to intense fire scars by feral cats

Hugh W. McGregor
Sarah Legge
Christopher N. Johnson
ResearchOpen Access02 Mar 2016
Scientific Reports

Volume: 6, P: 1-7
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

Russell L. McLaughlin
Dick Schijven
Michael C. O’Donovan
ResearchOpen Access21 Mar 2017
Nature Communications

Volume: 8, P: 1-12
Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia is a highly heritable genetic disorder, however, identification of specific genetic risk variants has proven difficult because of its complex polygenic nature—a large multi-stage genome-wide association study identifies 128 independent associations in over 100 loci (83 of which are new); key findings include identification of genes involved in glutamergic neurotransmission and support for a link between the immune system and schizophrenia.

Stephan Ripke
Benjamin M. Neale
Michael C. O’Donovan
Research22 Jul 2014
Nature

Volume: 511, P: 421-427
Australia’s mammal fauna requires a strategic and enhanced network of predator-free havens

Jeremy Ringma
Sarah Legge
Michael Bode
Correspondence15 Jan 2018
Nature Ecology & Evolution

Volume: 2, P: 410-411
A polygenic resilience score moderates the genetic risk for schizophrenia

Jonathan L. Hess
Daniel S. Tylee
Stephen J. Glatt
ResearchOpen Access06 Sept 2019
Molecular Psychiatry

Volume: 26, P: 800-815
Ex situ seed banks and the IUCN Red List

Extinct, or just extinct in the wild? Plants lost from in situ habitat, but represented in seed banks, are labelled extinct despite the potential for restoration. A change in the International Union for Conservation of Nature Red List definition of extinct in the wild is needed to improve the status and prospects of threatened plant species.

Sarah E. Dalrymple
Thomas Abeli
Comments & Opinion08 Feb 2019
Nature Plants

Volume: 5, P: 122-123
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Amendments and Corrections13 May 2019
Nature Genetics

Volume: 51, P: 1068
SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy

Delnaz Roshandel
Eric J. Sanders
Helen Cockerill
ResearchOpen Access28 Sept 2023
npj Genomic Medicine

Volume: 8, P: 1-11
Stable-isotope probing and metagenomics reveal predation by protozoa drives E. coli removal in slow sand filters

Sarah-Jane Haig
Melanie Schirmer
Christopher Quince
Research03 Oct 2014
The ISME Journal

Volume: 9, P: 797-808
Age at first birth in women is genetically associated with increased risk of schizophrenia

Guiyan Ni
Jacob Gratten
Michael C. O’Donovan
ResearchOpen Access05 Jul 2018
Scientific Reports

Volume: 8, P: 1-14

Search

The response and management of species sensitive to altered fire regimes

Author Correction: Ex situ seed banks and the IUCN Red List

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

Complement genes contribute sex-biased vulnerability in diverse disorders

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Extraterritorial hunting expeditions to intense fire scars by feral cats

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Biological insights from 108 schizophrenia-associated genetic loci

Australia’s mammal fauna requires a strategic and enhanced network of predator-free havens

A polygenic resilience score moderates the genetic risk for schizophrenia

Ex situ seed banks and the IUCN Red List

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy

Stable-isotope probing and metagenomics reveal predation by protozoa drives E. coli removal in slow sand filters

Age at first birth in women is genetically associated with increased risk of schizophrenia

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