Maladaptive immunity negatively impacts Alzheimer’s disease (AD). Here, the authors show dysfunctional CD38-expressing CD4+ T cells in individuals with familial AD before symptom onset. Targeting CD38 in an AD mouse model restored metabolic fitness, improved cognition, and modified meningeal immunity.
- Javier María Peralta Ramos
- Giulia Castellani
- Michal Schwartz
