Nature Search

Host control of persistent Epstein–Barr virus infection

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
Research19 Feb 2026
Nature

P: 1-5
Drawing boundaries between feasible and unfeasible zeolite intergrowths using high-throughput computational screening with synthesis validation

Determining the feasibility of intergrowths between zeolites is investigated using high-throughput atomistic simulations and experimental verification. Interfacial energy is an effective descriptor for identifying the feasibility of zeolite intergrowths and a zincosilicate zeolite intergrowth with three and nine rings is realized by hydrothermal syntheses.

Kota Oishi
Koki Muraoka
Akira Nakayama
Research20 Oct 2025
Nature Materials

Volume: 24, P: 1978-1984
Real-space observation of a two-dimensional electron gas at semiconductor heterointerfaces

Differential phase contrast scanning transmission electron microscopy probes the electric field distribution across a GaN-based semiconductor heterointerface.

Satoko Toyama
Takehito Seki
Naoya Shibata
Research20 Mar 2023
Nature Nanotechnology

Volume: 18, P: 521-528
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice

Hikari Takeshita
Koichi Yamamoto
Hiromi Rakugi
ResearchOpen Access08 Feb 2017
Scientific Reports

Volume: 7, P: 1-9
Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector

Satoko Kise
Ayano Iijima
Toshiyuki Sakaki
ResearchOpen Access28 Oct 2023
Scientific Reports

Volume: 13, P: 1-10
Direct observation of space-charge-induced electric fields at oxide grain boundaries

Here the authors directly observe space-charge-induced electric fields at yttria-stabilized zirconia grain boundaries, revealing how space charge layers corelate with grain boundary orientations, core atomic structures, and yttrium segregation amounts.

Satoko Toyama
Takehito Seki
Naoya Shibata
ResearchOpen Access18 Oct 2024
Nature Communications

Volume: 15, P: 1-9
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity

Chalcone synthase is the first committed enzyme in the plant flavonoid biosynthesis pathway, yet shows low product specificity in vitro. Here Waki et al. show that chalcone isomerase-like proteins bind to and reduce the catalytic promiscuity of chalcone synthase, ensuring efficient flavonoid production in planta.

Toshiyuki Waki
Ryo Mameda
Toru Nakayama
ResearchOpen Access13 Feb 2020
Nature Communications

Volume: 11, P: 1-14
Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

Yuki Murakami
Takaaki Ishibashi
Kuniaki Saito
ResearchOpen Access20 Jul 2016
Scientific Reports

Volume: 6, P: 1-12
Small extracellular vesicles in follicular fluids for predicting reproductive outcomes in assisted reproductive technology

Muraoka et al. assess the potential of small non-coding RNAs derived from small extracellular vesicles contained within ovarian follicular fluid to determine in predicting assisted reproductive technology outcomes. They find that a combination of small ncRNAs were differentially expressed between reproductive outcomes.

Ayako Muraoka
Akira Yokoi
Hiroaki Kajiyama
ResearchOpen Access28 Feb 2024
Communications Medicine

Volume: 4, P: 1-9
Nanoscale electromagnetic field imaging by advanced differential phase-contrast STEM

Direct characterization of nanoscale electromagnetic fields is crucial for propelling device development. This Review summarizes recent developments and applications of high-resolution electromagnetic field imaging by scanning transmission electron microscopy, demonstrating the real-space electromagnetic field and charge observations at device interfaces.

Satoko Toyama
Takehito Seki
Naoya Shibata
Reviews26 Nov 2024
Nature Reviews Electrical Engineering

Volume: 2, P: 27-41
An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection

Shiho Chiba
Maki Kiso
Yoshihiro Kawaoka
ResearchOpen Access14 Oct 2024
npj Vaccines

Volume: 9, P: 1-5
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Yukari Yada
Akihide Ohkuchi
Mariko Hida
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-13
Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax

Yan Liu
Yin Wang
Isao Kitajima
Research03 May 2001
Oncogene

Volume: 20, P: 2514-2526
Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia

Keizo Takao
Katsunori Kobayashi
Tsuyoshi Miyakawa
ResearchOpen Access06 Feb 2013
Neuropsychopharmacology

Volume: 38, P: 1409-1425
Comparison of drug sensitivity and genotypes of clinically isolated strains of levofloxacin-resistant Streptococcus pneumoniae obtained from Okinawa Island, the Japanese main island and Hong Kong

Satoko Sunagawa
Jiro Fujita
Tsukasa Uno
Research18 May 2011
The Journal of Antibiotics

Volume: 64, P: 539-545

Search

Host control of persistent Epstein–Barr virus infection

Drawing boundaries between feasible and unfeasible zeolite intergrowths using high-throughput computational screening with synthesis validation

Real-space observation of a two-dimensional electron gas at semiconductor heterointerfaces

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice

Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector

Direct observation of space-charge-induced electric fields at oxide grain boundaries

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Blood DNA virome associates with autoimmune diseases and COVID-19

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity

Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

Small extracellular vesicles in follicular fluids for predicting reproductive outcomes in assisted reproductive technology

Nanoscale electromagnetic field imaging by advanced differential phase-contrast STEM

An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax

Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia

Comparison of drug sensitivity and genotypes of clinically isolated strains of levofloxacin-resistant Streptococcus pneumoniae obtained from Okinawa Island, the Japanese main island and Hong Kong

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