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Showing 1–18 of 18 results
Advanced filters: Author: Saul A Villeda Clear advanced filters

  • Platelet factors transfer the benefits of young blood to the ageing brain in mice through CXCR3, which mediates the cellular, molecular and cognitive benefits of systemic PF4 on the aged brain.

    • Adam B. Schroer
    • Patrick B. Ventura
    • Saul A. Villeda
    ResearchOpen Access
    Nature
    Volume: 620, P: 1071-1079

  • Across species, how aging leads to progressive spatial memory decline is not fully understood. This study reports dysfunctional spatial coding by aged entorhinal grid cells and networks related to impaired spatial memory and identifies implicated neuronal gene expression changes.

    • Charlotte S. Herber
    • Karishma J. B. Pratt
    • Lisa M. Giocomo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-27

  • In this Review, Villeda and colleagues describe blood-to-brain communication from a systems physiology perspective, with an emphasis on blood-derived signals as potent drivers of both age-related brain dysfunction and brain rejuvenation.

    • Gregor Bieri
    • Adam B. Schroer
    • Saul A. Villeda
    Reviews
    Nature Neuroscience
    Volume: 26, P: 379-393

  • A brain-derived hormone, CCN3, is newly identified to have a role as an osteoanabolic factor to build bone in lactating females and in the viability of offspring.

    • Muriel E. Babey
    • William C. Krause
    • Holly A. Ingraham
    ResearchOpen Access
    Nature
    Volume: 632, P: 357-365

  • Aging is associated with cognitive impairment and degenerative processes in the brain. Here, Tony Wyss-Coray and colleagues report that exposure of aged mice to young blood improves learning and memory in aged mice. This effect is associated with structural improvements in dendritic spine density in the hippocampus and functionally with increased synaptic plasticity. These findings suggest that circulating factors in young blood can reverse impairments in learning, memory and synaptic plasticity in aged mice.

    • Saul A Villeda
    • Kristopher E Plambeck
    • Tony Wyss-Coray
    Research
    Nature Medicine
    Volume: 20, P: 659-663

  • Ageing is associated with deteriorating immune function and metabolic diseases. Here, the authors show that plasma levels of the stress-response protein MANF decline with age in various organisms and that MANF has beneficial effects on immune and metabolic function, particularly in the liver, in old mice.

    • Pedro Sousa-Victor
    • Joana Neves
    • Heinrich Jasper
    Research
    Nature Metabolism
    Volume: 1, P: 276-290

  • Brigger et al. show that adipose tissue eosinophil dysfunction with age underpins physiological features of ageing, including global inflammation, loss of physical fitness and myeloid skewing. Eosinophils transferred from young to aged mice reversed these features and improved immunological fitness in old age, in part via IL-4.

    • Daniel Brigger
    • Carsten Riether
    • Alexander Eggel
    Research
    Nature Metabolism
    Volume: 2, P: 688-702

  • In this study, the authors show that TGF-β/ALK5 and JNK signaling is necessary during the late stages of adult neurogenesis to promote the survival, migration and proper morphology of newborn neurons. In addition, constitutive activation of this pathway is able to promote improved performance on spatial and contextual learning tasks.

    • Yingbo He
    • Hui Zhang
    • Tony Wyss-Coray
    Research
    Nature Neuroscience
    Volume: 17, P: 943-952

  • Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia ‘off’ signal.

    • Aleksandra Deczkowska
    • Orit Matcovitch-Natan
    • Michal Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Exerkines are signalling moieties that are released in response to acute and/or chronic exercise that exert their effects through endocrine, paracrine and/or autocrine pathways. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions.

    • Lisa S. Chow
    • Robert E. Gerszten
    • Michael P. Snyder
    Reviews
    Nature Reviews Endocrinology
    Volume: 18, P: 273-289