Small peptide-derived catalysts are shown to be effective in the enantioselective sulfonylation of polyols. The observation that, using closely related catalysts, enantiotopic alcohols can be phosphorylated or sulfonylated, raises questions about the details of catalyst–substrate recognition and, from a biomimetic standpoint, the role of histidine residues in enzyme active sites.
- Kristin Williams Fiori
- Angela L. A. Puchlopek
- Scott J. Miller
