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Showing 1–5 of 5 results
Advanced filters: Author: Sebastian D Fugmann Clear advanced filters

  • The diversity of the receptors on our immune cells that recognize 'foreign' material is ensured by combining a set of gene segments to form the final receptor genes. A crucial player in that process has now been found.

    • Sebastian D. Fugmann
    News & Views
    Nature
    Volume: 416, P: 691-693

  • Experiments based on the requirement for immunoglobulin gene transcription provide new insights into the elusive role played by AID in immunoglobulin class switching and hypermutation.

    • Sebastian D. Fugmann
    • David G. Schatz
    News & Views
    Nature Immunology
    Volume: 4, P: 429-430

  • The AID/APOBEC cytidine deaminase family are nucleic acid editors, important for antigen receptor expression and thought to have evolved along with vertebrate adaptive immunity. Here the authors show this family may have evolved prior to adaptive immunity as members with cytidine deaminase activity are present and functional in invertebrate sea urchins and brachiopods.

    • Mei-Chen Liu
    • Wen-Yun Liao
    • Sebastian D. Fugmann
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • The vertebrate adaptive immune system is defined by antigen-binding receptors of diverse specificity and the cells that express them. But how did this system evolve? Here, our current understanding of the evolutionary acquisition of the factors required to generate such receptor variation and cellular complexity is discussed.

    • Gary W. Litman
    • Jonathan P. Rast
    • Sebastian D. Fugmann
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 543-553