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Analysis of soundscape data from 139 globally distributed sites reveals that sounds of biological origin exhibit predictable rhythms depending on location and season, whereas sounds of anthropogenic origin are less predictable. Comparisons between paired urban–rural sites show that urban green spaces are noisier and dominated by sounds of technological origin.

Augmin is essential for microtubule nucleation during cell division. This study reveals how the conserved calponin homology domain of the augmin subunit HAUS6 binds to microtubules to orient augmin for microtubule branching.

What is the state of trust in scientists around the world? To answer this question, the authors surveyed 71,922 respondents in 68 countries and found that trust in scientists is moderately high.

Guetter et al. identify a melanoma-associated chondroitin sulfate proteoglycan-positive subpopulation of metastasis founder cells from lymph node biopsies of patients with melanoma and observe that they mediate immune evasion and predict systemic metastasis and poor outcomes.

Literature produced inconsistent findings regarding the links between extreme weather events and climate policy support across regions, populations and events. This global study offers a holistic assessment of these relationships and highlights the role of subjective attribution.

Nanocatalysts can restructure during reactions. Here, the authors dynamically varied the stoichiometry of the surface species in 30 % Pd-in-Au nanoparticles by modulating H2 and O2 gases and quantified the formation kinetics of Pd regions and oxides.

Hyperfine splitting was measured using the laser spectroscopy of accelerator-produced hydrogen-like bismuth ions. This demonstrates the feasibility of such measurements with other exotic ions with low production yields in a storage ring.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Hot electrons are generated when energy is transferred from an incoming photon, enabling an electron from a metal surface to become mobile. Here, the authors irradiate plasmonically active silver core-satellite superstructures and use the hot electrons to effect chemical reactions via photorecycling.

The combination of nickel-catalysis and sensitized electron transfer is underdeveloped. Now, a nickel-catalysed sensitized electron transfer method for the synthesis of methyl thioesters from carboxylic acids is reported. Mechanistic investigations reveal that the merger of photocatalytic electron transfer, energy transfer and nickel catalysis plays an essential role in this thioesterification reaction.

SWCNTs are pivotal optical molecular sensors, but until now, the underlying mechanism how the binding of analytes affects the fluorescence remained elusive. This study has elucidated that coupling between exciton-coupled plasmon modes of SWCNTs and THz water modes is a significant factor.

Cyanoarene-based photocatalysts are widely used due to their catalytic performance, but the formation of the active species and its potential degradation pathways are poorly understood. Here, the authors investigate these pathways under commonly-used photoredox-mediated reaction conditions.

Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous and aggressive type of T-cell lymphoma. Here, the authors perform single-cell analyses of human and murine PTCL-NOS tumors, and identify a subtype defined by the loss of SMARCB1 that could be targeted with HDAC-inhibitor combination therapies.

Forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.

Branched-chain amino acid transaminase 1, the enzyme that initiates the catabolism of branched-chain amino acids, is involved in glioma pathogenesis, making it a potential therapeutic target.

Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify single point mutations and RNA-binding proteins that can control CD19 splicing and be associated with CD19 CAR-T therapy resistance.

Niemann-Pick type C disease is a rare childhood neurodegenerative disorder predominantly caused by mutations in NPC1, resulting in abnormal late endosomal and lysosomal defects. Here the authors show that NPC1 disruption largely impairs microglial function.

Cross-linking mass spectrometry (XLMS) allows mapping of protein-protein and protein-RNA interactions, but the analysis of protein-DNA complexes remains challenging. Here, the authors develop a UV light-based XLMS workflow to determine protein-DNA interfaces in reconstituted chromatin and isolated nuclei.

Martini 3.0 is an updated and reparametrized force field for coarse-grained molecular dynamics simulations with new bead types and an expanded ability to model molecular packing and interactions.

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

The authors show that a large fraction of tumour mutations is immunogenic and predominantly recognized by CD4⁺ T cells; they use these data to design synthetic messenger-RNA-based vaccines specific against tumour mutations, and show that these can reject tumours in mice.

B cell antigen receptors containing immunoglobulin G (IgG) or IgE, but not those containing IgM, show enhanced signaling. Wienands and colleagues trace this boosted signaling capacity to conserved IgG and IgE cytoplasmic tyrosine residues that recruit the adaptor Grb2.

The International Barley Genome Sequencing Consortium reports sequencing and assembly of a reference genome for barley, Hordeum vulgare.

Hugh Watkins, Sekar Kathiresan, Ruth McPherson, Martin Farrall and colleagues report the results of a large genome-wide association meta-analysis of coronary artery disease based on 1000 Genomes imputation. They identify ten new risk loci and show that susceptibility to this disease is largely determined by common SNPs with small effect sizes.

Species richness across taxa showed U-shaped patterns along a forest development gradient in the northern Alps, which remained stable with elevation. Habitat specialization decreased for all taxa and beta diversity varied across taxa with elevation.

The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immunity in mouse tumour models; initial results in advanced melanoma patients indicate potential efficacy in humans.

Topological spin textures are promising for their potential application in racetrack memory devices. Here, the characteristic Hall transport signature of antiskyrmions is investigated in Mn_1.4PtSn, providing a platform for higher magnetic and temperature tunability over traditional skyrmion compounds.