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Guetter et al. identify a melanoma-associated chondroitin sulfate proteoglycan-positive subpopulation of metastasis founder cells from lymph node biopsies of patients with melanoma and observe that they mediate immune evasion and predict systemic metastasis and poor outcomes.

Analysis of ground-sourced and satellite-derived models reveals a global forest carbon potential of 226 Gt outside agricultural and urban lands, with a difference of only 12% across these modelling approaches.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Choi et al. highlight the centrality of glycolysis in squamous cell carcinoma, revealing the glycolysis-dampening tumour suppressor role of Sirt6, and identifying a subset of highly glycolytic tumour-propagating cells with elevated antioxidant capacity.

Barium tagging is a key ingredient for future detectors of neutrinoless double beta decay in low-background environments. Here, the authors demonstrate fluorescence imaging of single Ba2+ ions in high pressure Xenon gas, by comparing activity between Ba2+ chelated and unchelated samples of crown-ether chemosensors.

Han et al. report the existence of neural stem cells (NSCs) outside the central nervous system and show that these peripheral NSCs display features similar to brain NSCs, including the ability to differentiate into mature neurons.

The molecular genetic landscape of leiomyosarcoma (LMS) is largely unknown. Here, the authors identify frequent DNA copy number alterations, whole-genome duplication, TP53 and RB1 inactivation, alternative telomere lengthening, and genomic imprints of defective DNA repair via homologous recombination as a potential therapeutic target in LMS patients.

Stable vision in quickly changing environments requires a mechanism that ensures that contrast is computed correctly when light conditions change rapidly. Here authors identify the circuits and algorithm of this mechanism in the fruit fly Drosophila.

Integrating inventory data with machine learning models reveals the global composition of tree types—needle-leaved evergreen individuals dominate, followed by broadleaved evergreen and deciduous trees—and climate change risks.

Satellite-borne radar systems are promising tools to obtain spatial habitat data with complete geographic coverage. Here the authors show that freely available Sentinel-1 radar data perform as well as standard airborne laser scanning data for mapping biodiversity of 12 taxa across temperate forests in Germany.

Although co-occurring species may differ widely in their response traits, coordinated functional trait shifts may emerge at the community level in response to environmental factors. Here, the authors use data from 150 grassland sites to identify a coordinated slow-fast strategy response to land-use intensification across above- and belowground taxa.

One of the possible events signaling a neutrinoless double beta decay is a Xe atom decaying into a Ba ion and two electrons. Aiming at the realisation of a detector for such a process, the authors show that Ba ions can be efficiently trapped (chelated) in vacuum by an organic molecule layer on a surface.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Most confirmed susceptibility variants for epithelial ovarian cancer lie in non-protein-coding sequences. Here Permuth-Wey and colleagues investigate variants in 3′ untranslated regions (UTRs) and uncover a new susceptibility locus.

HNF1B is overexpressed in the clear cell subtype and epigenetically silenced in the serous subtype of ovarian cancer. Pearce and colleagues now show that genetic variants in HNF1B are differentially associated with risks of developing these two cancer subtypes, possibly through an epigenetic mechanism.

Analyses of a dataset of arthropod biomass, abundance and diversity in grassland and forest habitats in Germany for the period 2008–2017 reveal that drivers of arthropod declines act at the landscape level.

Loechner et al. present an expert consensus on how to e-mental health, from the development to research and evaluation of e-mental health interventions, a useful guide with practical recommendations for researchers and practitioners wanting to explore the field of e-mental health.

Adaptation to heat stress through the use of air conditioners has received increasing attention. Here the authors show that income and humidity adjusted temperature are common determinants for adopting air conditioning, but their relative contribution varies in relation to household characteristics.

A chemical screen identified BET bromodomain inhibitors as promoters of keratinocyte regenerative function and skin wound healing. Specifically, low-dose transient treatment with BET inhibitors imposes an activated, migratory state in keratinocytes.

This Comment explores new approaches to enrich large-scale population data, including incorporating macro-environmental and digital health measures.

Analyses of data from the UK Biobank reveal different urban living environments that are associated with affective, anxiety and emotional instability symptom groups and mediated by distinct neurological and genetic pathways in adults.

Carbon pricing can alter income distribution. With a focus on Bangladesh, India, Indonesia, Pakistan, Philippines, Thailand, Turkey and Vietnam, this study compares four types of carbon pricing schemes and finds substantial variation in distributional effects across policy designs and countries.

Various models of cardiac arrhythmia have been developed in several different animal species to study the mechanisms of disease. In this Review, Clauss and colleagues summarize the advantages and disadvantages of the models and species used in arrhythmia research and provide guidance to investigators planning experiments in this field.

In this Perspective, the authors present a model of assessing urban environmental factors’ impact on mental health by using UrbanSat measures and data from adolescents in the ABCD Study.

Energy use is crucial for economic development, but drives greenhouse-gas emissions. A low-carbon growth path requires a radical transformation of the energy system that would be too costly for developing nations. Efforts should focus on feasible mitigation actions such as fossil fuel subsidy reform, decentralized access to modern energy and fuel switching in the power sector.

Integrative analyses that incorporate different levels of ‘-omics’ data represent a powerful tool for deciphering the biological mechanisms that underlie environmental influences on mental health and disease. This Comment highlights various aspects of such multi-omics approaches, using the example of the EU-funded environMENTAL project.

This Comment presents a high-level protocol for data harmonization within large cohorts, in which it postulates four main steps including (1) expert review, (2) pre-statistical harmonization, (3) statistical harmonization, and (4) validation.

The focus of much of contemporary research ethics is on compliance with established protocols. However, large data-driven neuroscience research raises new ethical concerns that have no agreed-upon solution. Here we reflect on these challenges and propose better integration of public and patient involvement in this evolving landscape.