Germinal center B cell development is promoted by T follicular helper cells. Chen Dong and his colleagues show that Foxp3+ regulatory T cells expressing Bcl6 and CXCR5, two molecules highly expressed in T follicular helper cells, are present in humans and mice and arise from natural regulatory T cells. In vivo, these CXCR5+Bcl6+ regulatory T cells modulate germinal center responses.
- Yeonseok Chung
- Shinya Tanaka
- Chen Dong
