Population-based studies in the haematopoietic system have suggested that global transcriptional noise drives lineage choice, with transcriptome-wide reversible changes occurring in self-renewing populations. Enver and colleagues use single-cell analysis to show that multipotent cells undergo independent activation of a few individual regulators that can sometimes induce a transition to the committed state.
- Cristina Pina
- Cristina Fugazza
- Tariq Enver
