The function of serotonin receptors and the neuroimmune relationship in psoriasis is not fully understood. Here, the authors find HTR2A antagonistic drugs worsened psoriasis outcomes in a study population, and that HTR2A modulation reduced psoriasis severity in imiquimod mouse models and that this involved HTR2A-expressing monocyte-derived Langerhans cells.
- Yeh Fong Tan
- Chen-Yun Yeh
- Yungling Leo Lee
