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Showing 1–11 of 11 results

Advanced filters: Author: Shengqi Pan Clear advanced filters

Citrullination modulation stabilizes HIF-1α to promote tumour progression

Post-translational modifications on HIF-1α can regulate its stability and activity in tumoral processes. Here, the authors show that PADI4-mediated citrullination avoids HIF-1α degradation to promote hepatocellular carcinoma progression and this can be prevented by a PADI4 antagonist

Rui Chen
Zhiyuan Lin
Ping Gao
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-15
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

Li and colleagues show how cMyc promotes tumourigenesis by promoting succinate dehydrogenase complex subunit A acetylation by activating SKP2-mediated degradation of SIRT3. This leads to succinate accumulation and consequent tumour-specific gene expression.

Shi-Ting Li
De Huang
Ping Gao
Research16 Mar 2020
Nature Metabolism

Volume: 2, P: 256-269
Tumor-associated macrophages/C-X-C motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling

Bowen Yang
Guanzhi Li
Zhiyu Wang
ResearchOpen Access11 Oct 2024
Cell Death & Disease

Volume: 15, P: 1-15
Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma

Xiuyun Xu
Jiaxiang Xie
Cheng Wang
ResearchOpen Access07 Sept 2023
International Journal of Oral Science

Volume: 15, P: 1-13
CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity

G. Aaron Holling
Colin A. Chavel
Scott H. Olejniczak
ResearchOpen Access18 Jan 2024
Cellular & Molecular Immunology

Volume: 21, P: 260-274
Construction and optimization of ecological corridors in coastal cities based on the perspective of “structure-function”

Bowen Jin
Jianwei Geng
Guochang Ding
ResearchOpen Access14 Nov 2024
Scientific Reports

Volume: 14, P: 1-19
Anisotropy-free arrayed waveguide gratings on X-cut thin film lithium niobate platform of in-plane anisotropy

A universal strategy to realize anisotropy-free dispersive components, such as arrayed waveguide gratings, on a uniaxial in-plane anisotropic thin-film lithium niobate platform is introduced for the first time.

Junjie Yi
Changjian Guo
Liu Liu
ResearchOpen Access29 Jun 2024
Light: Science & Applications

Volume: 13, P: 1-11
Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering

Peng Cheng
Cong Mao
Shengqi Wang
ResearchOpen Access05 Jul 2024
Cell Research

Volume: 34, P: 630-647
Unhealthy lifestyle factors and the risk of colorectal cancer: a Mendelian randomization study

Xingyuan Li
Zewen Chang
Qingchao Tang
ResearchOpen Access15 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
Immune signature driven by ADT-induced immune microenvironment remodeling in prostate cancer is correlated with recurrence-free survival and immune infiltration

Xingbo Long
Huimin Hou
Hong Zhang
ResearchOpen Access19 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-14
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

Linchong Sun
Libing Song
Huafeng Zhang
Research20 Mar 2015
Cell Research

Volume: 25, P: 429-444