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Interpretation of Computed Tomography Angiography for intracranial aneurysm diagnosis can be time-consuming and challenging. Here, the authors present a deep-learning-based framework achieving improved performance compared to that of radiologists and expert neurosurgeons.

Bacterial cells actively change their size and shape in response to external environments. Here, Shi et al. explore how cells regulate their morphology during rapid environmental changes, showing that the characteristic dynamics of surface area-to-volume ratio are conserved across genetic and chemical perturbations, as well as across species and growth temperatures.

Defect states in perovskites dictate the charge carriers behaviour, thus the ultimate optical and electrical properties. Here, the authors in-situ investigate trapped carrier dynamics in MAPbI₃ thin films with ultra-fast temporal and high energetic resolution by means of ultrafast photocurrent spectroscopy.

Zhang et al. report non-destructive halide exchange by employing butylammonium halide incorporated post-treatment to achieve perovskite with low trap density and tuneable bandgap for blue LEDs, with external quantum efficiencies of 23.6%, 20.9%, and 15.5% for emission peaks at 488, 478, and 468 nm, respectively.

The functions of microvesicles (MVs) in gastric cancer are less studied compared to other types of extracellular vesicles. Here, the authors report that in Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC), Olfactomedin 4 protein is enriched in secreted MVs to promote EBVaGC progression by inhibiting the Hippo signaling in tumor cells.

Genomic and phenomic screens of 827 wheat landraces from the A. E. Watkins collection provide insight into the wheat population genetic background, unlocking many agronomic traits and revealing haplotypes that could potentially be used to improve modern wheat cultivars.

In this triple-arm, placebo-controlled phase 3 trial, first-line treatment of patients with extensive-stage small-cell lung cancer with the anti-PD-L1 benmelstobart, tyrosine kinase inhibitor anlotinib and chemotherapy (CT) showed improved survival outcomes compared with anlotinib and CT or CT alone.

Cryogenic electron microscopy structures of Mycobacterium tuberculosis ATP synthase and human ATP synthase bound to the anti-tuberculosis drug bedaquiline or its analogue TBAJ-587 shed light on drug binding and could lead to new treatments for tuberculosis.

Endophilin A1 protein is known to be elevated in Alzheimer’s disease (AD). Here the authors show that endophilin A1 overexpression exacerbates synaptic deficits in a mouse model of AD.

The decarbonization of the global iron and steel industry is important for energy systems mitigation. Using a facility-level database, this Article presents cost-effective, region-specific strategies targeting plants with a large age-to-capacity ratio and/or high emissions intensity.

Previous studies of exciton condensates in moire heterostructures have been limited to large layer separation or one carrier type. Here the authors report a complete sequence of exciton condensates at both electron and hole fillings in large-angle twisted double bilayer graphene without a spacer layer.

To enable high-performance seasonal thermal energy storage for decarbonized solar heating, the authors propose an effective method to realize ultrastable supercooled erythritol, with an ultrahigh supercooling >150 ˚C, by making it more viscous.

Targeted delivery of mRNA using lipid nanoparticles is currently a challenge. Here, the authors examine the composition of LNPs and report changes to the standard formulation can address issues with liver accumulation and allow for increased tissue specific targeting.

One of the key challenges in dielectric ceramics for energy storage lies in the comprehensive optimization of their properties. Here, the authors establish an equitable system considering performance and structure evolution in a lead-free ceramic capacitor, achieving a broad-high temperature performance.

Clean-up of oil spills is a global challenge because current methods are ineffective when facing highly viscous oil with low fluidity. Here the authors develop a tool for efficient and high-throughput clean-up of highly viscous oil spills.

A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.

Gboxin, an inhibitor of oxidative phosphorylation (OXPHOS), can suppress the proliferation of glioblastoma (GBM) cells. Here the authors describe the design of a cancer cell-mitochondria hybrid membrane camouflaged reactive oxygen species (ROS)-responsive nanoparticle loaded with Gboxin, showing anti-tumor responses in GBM preclinical models.

Overcoming the immunosuppressive tumour microenvironment is a challenge. A strategy to close the cancer–immunity cycle has been reported by integrating lipid nanoparticle–mRNA formulations and dendritic cell therapy to promote tumour elimination and develop antitumour immunity.

Ubiquitination and deubiquitination processes regulate the stability of PD-1, affecting T cell biology. Here the authors identify the ubiquitin-specific protease 5 (USP5) as a deubiquitinase for PD-1 and show that USP5 inhibition in combination with a MEK inhibitor or anti-CTLA-4 could promote anti-tumor immune responses in preclinical models.

Fluorescent probes are used in a number of fields but suffer from a lack of quantifiable results due to environmental effects. Here, the authors report on a dual-emission probe which can be used to detect the amount of probe present and the emission from detection applications to allow for quantification.

SARS-CoV-2-related coronaviruses are identified in Malayan pangolins (Manis javanica); these pangolin-associated coronaviruses belonged to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2.

West Pacific ferromanganese crust provides new insights to Late Miocene Cooling associated with the increased continental phosphorus weathering.

RAMP3, a component of the receptor for the neuropeptide CGRP, has a cell-intrinsic role in T helper type 1 cell fate determination.

The pluripotency program is maintained by transcription factors from the Sox and POU families. Here they identify SOX and POU factors from unicellular relatives of animals and show that unicellular SOX can replace SOX2 to induce pluripotency, whilst unicellular POU differs from OCT4.

The collective-flow-assisted nuclear shape-imaging method images the nuclear global shape by colliding them at ultrarelativistic speeds and analysing the collective response of outgoing debris.

Obesity is a significant health risk, and current treatments are inadequate. This study reveals that AA005, an annonaceous acetogenin mimic, targets mitochondrial HADHA in adipose tissue to boost thermogenesis via the UCP1 pathway, providing a promising new strategy for obesity treatment.

In Klinefelter syndrome, gene dysregulation due to the extra X chromosome leads to delayed development of fetal germ cells (FGCs), and aberrant interactions between Sertoli cells and FGCs disrupt the migration of late FGCs to the basement membrane.

Rapid degradation inducing overdose toxicity remains challenging in porous biodegradable bone scaffolds. Here the authors present multiscale architecture design on ZnLi scaffolds with 90% porosity orchestrates immune responses and subsequent bone regeneration.

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

Inactivation is an intrinsic property of Na_V channel, but the mechanism for slow inactivation is not fully understood. Here, authors show a Na_VEh structure in a potential slow-inactivated state, elucidating structural basis for slow inactivation.

Neural circuitry conveying visual information to the medial entorhinal cortex (MEC), a crucial region for spatial cognition, is not fully understood. Here, the authors report a direct pathway from the secondary visual cortex to MEC layer 5a in mice and its involvement in memory-guided navigation, thus revealing a role of deep MEC in sensory information transmission.

Pseudotyping messenger RNA-packaging virus-like particles with a glycoprotein recognizing a surface protein on dendritic cells led to higher humoral and adaptive immune responses in mice.

Ferroelectric HfO₂ is faced with an oxygen vacancy dilemma, which favors the polar phase but harm to switching behaviors. Here, the authors propose a donor-acceptor co-doping method to enhance polarization switching characteristics of the HfO₂ films.

In this study, Hu et al. identify a new mechanism through which sirtuin-4 fine-tunes urea cycle flux through decarbamylation of ornithine transcarbamylase to ensure proper ammonia detoxification upon increased amino acid catabolism.

Iron metabolism dysregulation is associated with various diseases including cancer. Here, the authors show that one iron-triggered lncRNA LncRIM regulates cellular iron metabolism effectively by wiring up the Hippo-YAP  signaling pathway and promotes breast cancer development.

Soil viruses could have a disproportionate role in ecosystem functioning. Here, the authors combine multiple data and approaches to explore diversity and distribution of P-acquisition genes encoded by soil bacteriophages, suggesting the importance of viral auxiliary metabolism for nutrient cycling.

The efficiencies of materials-based catalysts are determined by the surface atomic and electronic structures, but harnessing this relationship can be challenging. Here, by engineering strain into cobalt oxide, the authors transform a once poor hydrogen evolution catalyst into one that is competitive with the state of the art.

Glioblastoma stem-like cells (GSCs) contribute to therapeutic resistance and recurrence of glioblastomas. Here the authors show that Insulin-like Growth Factor-Binding Protein 5 (IGFBP5) is a ligand for Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) promotes GSCs invasion.

The molecular differences between the two major gastric cancer subtypes diffuse-type gastric cancer (DGC) and intestinaltype gastric cancer (IGC) remain to be investigated. Here, integrated analysis of proteome, phospho-proteome and transcription factor activity for DGC and IGC reveals potential subtypes.