Nature Search

Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking

The mechanism underlying abnormal pain perception in autism remains unclear. Here authors show that histone lactylation decreases Dock4, an autism-related gene, to modulate heat pain by impairing Dynein-mediated Nav1.7 membrane trafficking, providing insights into thermosensor-independent mechanisms.

Man-Xiu Xie
Ren-Chun Lai
Xiao-Long Zhang
ResearchOpen Access04 Aug 2025
Nature Communications

Volume: 16, P: 1-26
Exploring the evolution of pre-service teachers’ beliefs about English for specific purposes (ESP) through case studies from a teacher education program

Yu Shi
Xue Shen
Yan Chang
ResearchOpen Access30 Sept 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-12
Electrochemically driven regioselective C−H phosphorylation of group 8 metallocenes

Metallocene-based phosphines are compounds with potential use in catalysis. Here, the authors report the electrochemical regioselective functionalization of group 8 metallocenes with phosphine oxides; over 60 examples of phosphorylated (benzo)ferrocenes and ruthenocenes can be accessed via this method without the need for a preinstalled directing group.

Hao Zheng
Chang-Hui Liu
Qing-An Chen
ResearchOpen Access17 Jun 2022
Nature Communications

Volume: 13, P: 1-10
Photo-induced catalytic halopyridylation of alkenes

The Mizoroki–Heck reaction and its reductive analogue are staples of organic synthesis, but the ensuing products often lack a chemical handle for further transformation. Here the authors present a method to add a heterocycle and transformable halide across a double bond via iridium photocatalysis.

Shi-Yu Guo
Fan Yang
Qing-An Chen
ResearchOpen Access11 Nov 2021
Nature Communications

Volume: 12, P: 1-9
Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress

Malfunctioning of cellular organelles, such as the endoplasmic reticulum (ER) and mitochondria, can have a role in stress-induced pathophysiological changes. Here, the authors show that increased mitochondria‐associated endoplasmic reticulum membranes contacts related to ATP-P2X7 receptor signaling contribute to stress responses in microglia and the development of depression-like behavior in male mice.

Jia-Rui Zhang
Shi-Yu Shen
Jin Yu
ResearchOpen Access18 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Scalable X-ray scintillators with bright singlet-triplet hybrid self-trapping excitons

Size-scalable ZnO QD scintillators for advanced X-ray imaging.Introduction

Shi-Yu Song
Chao-Jun Gao
Chong-Xin Shan
ResearchOpen Access22 Jul 2025
Light: Science & Applications

Volume: 14, P: 1-12
Time-dependent physical unclonable functions by long-lived triplet excitons in carbon dots

Concept and application diagram based on TD-PUF.

Yan-Wei Hu
Qing Cao
Kai-Kai Liu
ResearchOpen Access20 Aug 2025
Light: Science & Applications

Volume: 14, P: 1-13
The influence of early-life adversity on the coupling of structural and functional brain connectivity across childhood

Modeling neurodevelopmental trajectories in a pediatric cohort reveals accelerated decrease in correlation between brain structural and functional connectivity in children exposed to high levels of prenatal adversity.

Shi Yu Chan
Zhen Ming Ngoh
Ai Peng Tan
ResearchOpen Access04 Jan 2024
Nature Mental Health

Volume: 2, P: 52-62
Visible light-induced chemoselective 1,2-diheteroarylation of alkenes

Visible-light photocatalysis has evolved as a powerful technique to enable controllable radical reactions and the exploration of new photocatalytic mode for product diversity is of great significance. Herein, the authors present a photo-induced chemoselective 1,2-diheteroarylation of unactivated alkenes utilizing halopyridines and quinolines.

Shi-Yu Guo
Yi-Peng Liu
Qing-An Chen
ResearchOpen Access19 Jul 2024
Nature Communications

Volume: 15, P: 1-10
Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis

Peritoneal metastasis is one of the most common forms of death for gastrointestinal cancers, however, its cell composition is incompletely understood. Here, the authors use single cell RNA-seq of peritoneal metastases from 35 patients and show diversity in immune cells, and plasticity in cancer cell phenotypes and autophagy related genes as biomarkers of prognosis.

Xuan-Zhang Huang
Min-Jiao Pang
Zhen-Ning Wang
ResearchOpen Access14 Feb 2023
Nature Communications

Volume: 14, P: 1-22
Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus

The genomic heterogeneity of clear cell renal cell carcinoma (ccRCC) across populations is poorly understood. Here, the authors analyse a cohort of Chinese ccRCC cases revealing a mutational signature associated with aristolochic acid exposure, and higher mutational burden and enrichment for BAP1 and SETD2 mutations in ccRCC cases associated with tumor thrombus.

Xiang-Ming Wang
Yang Lu
Lu-Lin Ma
ResearchOpen Access06 Feb 2020
Nature Communications

Volume: 11, P: 1-11
Anti-dissolution Pt single site with Pt(OH)(O₃)/Co(P) coordination for efficient alkaline water splitting electrolyzer

Platinum is the most active catalyst for cathodic hydrogen evolution, however it is inefficient for anodic oxygen evolution. Here, authors examine Pt single sites in cobalt hydrogen phosphate as oxygen evolution catalysts in water splitting electrolyzers.

Lingyou Zeng
Zhonglong Zhao
Shaojun Guo
ResearchOpen Access02 Jul 2022
Nature Communications

Volume: 13, P: 1-9
Author Correction: Anti-dissolution Pt single site with Pt(OH)(O₃)/Co(P) coordination for efficient alkaline water splitting electrolyzer

Lingyou Zeng
Zhonglong Zhao
Shaojun Guo
Amendments and CorrectionsOpen Access25 Jul 2022
Nature Communications

Volume: 13, P: 1
Neural mechanisms underlying strain preference behaviour and plasticity in mice

Kai-zhen Peng
Li-li Tan
Xiao-min Zhang
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-20
Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1

Dan-Hong Xu
Jian-Kui Du
Yu-Jian Liu
ResearchOpen Access19 Apr 2023
Cell Death & Disease

Volume: 14, P: 1-12
Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

Xiao-yun Niu
Xi-xiu Xie
Rui-tian Liu
ResearchOpen Access08 Apr 2024
Cell Death Discovery

Volume: 10, P: 1-15
TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons

Guolin Yang
Min Jia
Yun Stone Shi
ResearchOpen Access03 Jan 2024
Cell Discovery

Volume: 10, P: 1-15
Mechanisms of wheat (Triticum aestivum) grain storage proteins in response to nitrogen application and its impacts on processing quality

Ting Zheng
Peng-Fei Qi
You-Liang Zheng
ResearchOpen Access09 Aug 2018
Scientific Reports

Volume: 8, P: 1-13
Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma

Xi-Ya Li
Ji-Chuan Wu
Lan Wang
ResearchOpen Access09 Nov 2022
Leukemia

Volume: 37, P: 164-177
Ultraviolet phosphorescent carbon nanodots

Ultraviolet high-energy photons of phosphorescent carbon dots for antibacterial applications. Herein, the UV phosphorescent CNDs were achieved by decreasing conjugation size and spatial confinement. As a demonstration, the CNDs are used to inactivate gram-negative/positive bacteria.

Shi-Yu Song
Kai-Kai Liu
Chong-Xin Shan
ResearchOpen Access20 May 2022
Light: Science & Applications

Volume: 11, P: 1-11
Production of gold/silver doped carbon nanocomposites for effective photothermal therapy of colon cancer

Fang Liu
Xiao-di Wang
Shi-yu Du
ResearchOpen Access06 May 2020
Scientific Reports

Volume: 10, P: 1-9
PEST-containing nuclear protein regulates cell proliferation, migration, and invasion in lung adenocarcinoma

Da-Yong Wang
Ya Hong
Xin-Ying Ji
ResearchOpen Access14 Mar 2019
Oncogenesis

Volume: 8, P: 1-14
Effect of puerarin in promoting fatty acid oxidation by increasing mitochondrial oxidative capacity and biogenesis in skeletal muscle in diabetic rats

Xiu-fang Chen
Lei Wang
Qian Gao
ResearchOpen Access12 Jun 2018
Nutrition & Diabetes

Volume: 8, P: 1-13
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways

Shi-Yu Lu
Chang-Yuan Wang
Mo-Zhen Liu
ResearchOpen Access13 Jun 2017
Scientific Reports

Volume: 7, P: 1-16

Search

Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking

Exploring the evolution of pre-service teachers’ beliefs about English for specific purposes (ESP) through case studies from a teacher education program

Electrochemically driven regioselective C−H phosphorylation of group 8 metallocenes

Photo-induced catalytic halopyridylation of alkenes

Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress

Scalable X-ray scintillators with bright singlet-triplet hybrid self-trapping excitons

Time-dependent physical unclonable functions by long-lived triplet excitons in carbon dots

The influence of early-life adversity on the coupling of structural and functional brain connectivity across childhood

Visible light-induced chemoselective 1,2-diheteroarylation of alkenes

Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis

Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus

Anti-dissolution Pt single site with Pt(OH)(O₃)/Co(P) coordination for efficient alkaline water splitting electrolyzer

Author Correction: Anti-dissolution Pt single site with Pt(OH)(O₃)/Co(P) coordination for efficient alkaline water splitting electrolyzer

Neural mechanisms underlying strain preference behaviour and plasticity in mice

Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1

Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons

Mechanisms of wheat (Triticum aestivum) grain storage proteins in response to nitrogen application and its impacts on processing quality

Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma

Ultraviolet phosphorescent carbon nanodots

Production of gold/silver doped carbon nanocomposites for effective photothermal therapy of colon cancer

PEST-containing nuclear protein regulates cell proliferation, migration, and invasion in lung adenocarcinoma

Effect of puerarin in promoting fatty acid oxidation by increasing mitochondrial oxidative capacity and biogenesis in skeletal muscle in diabetic rats

The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways

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