Nature Search

Electron-density-informed effective and reliable de novo molecular design and optimization with ED2Mol

A deep generative model is developed for de novo molecular design and optimization by leveraging electron density. Wet-laboratory assays validated its reliability to generate diverse bioactive molecules—orthosteric and allosteric, inhibitors and activators.

Mingyu Li
Kun Song
Jian Zhang
Research20 Aug 2025
Nature Machine Intelligence

Volume: 7, P: 1355-1368
Integration of chemical and physical inputs for monitoring metabolites and cardiac signals in diabetes

A wristband combines continuous glucose monitoring with real-time detection of physiological signals to track glucose metabolism.

An-Yi Chang
Muyang Lin
Joseph Wang
Research02 Jul 2025
Nature Biomedical Engineering

P: 1-16
Dyna-vivo-seq unveils cellular RNA dynamics during acute kidney injury via in vivo metabolic RNA labeling-based scRNA-seq

A fundamental objective of genomics is to track variations in gene expression program. Here, authors developed Dyan-vivo-seq, which offers unprecedented insights into temporal RNA dynamics within intricate and dynamic biological systems at single-cell resolution.

Kun Yin
Yiling Xu
Chaoyong Yang
ResearchOpen Access14 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Well-TEMP-seq as a microwell-based strategy for massively parallel profiling of single-cell temporal RNA dynamics

Gene expression of cells is a heterogeneous and dynamic program involved in various biological processes. Here, authors develop Well-TEMPseq, a high-throughput, cost-effective, and accurate method for massively parallel profiling of the temporal dynamics of single-cell gene expression.

Shichao Lin
Kun Yin
Chaoyong Yang
ResearchOpen Access07 Mar 2023
Nature Communications

Volume: 14, P: 1-11
A fingertip-wearable microgrid system for autonomous energy management and metabolic monitoring

A wearable microgrid powered solely by fingertip perspiration can monitor metabolic biomarkers over extended periods of time.

Shichao Ding
Tamoghna Saha
Joseph Wang
Research03 Sept 2024
Nature Electronics

Volume: 7, P: 788-799
Patterns and driving forces of dimensionality-dependent charge density waves in 2H-type transition metal dichalcogenides

The dimensional dependence of charge density wave (CDW) in two-dimensional dichalcogenides remains puzzled. Here, Lin et al. study trends of CDW ordering in an isoelectronic group of materials 2H-MX₂ and provide a unified understanding involving several microscopic factors.

Dongjing Lin
Shichao Li
Mohammad Saeed Bahramy
ResearchOpen Access15 May 2020
Nature Communications

Volume: 11, P: 1-9
Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases

Genome-wide association meta-analyses identify more than 350 loci associated with atrial fibrillation. A polygenic score derived from these results improves atrial fibrillation risk prediction compared to published clinical and polygenic scores.

Carolina Roselli
Ida Surakka
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 539-547
Self-pressurizing nanoscale capsule catalysts for CO₂ electroreduction to acetate or propanol

CO₂ electroreduction to multicarbon products is desirable but challenging. Now, self-pressurizing nanoscale capsule catalysts are synthesized. The self-pressurising capsules harness high-pressure CO environments for selective acetate or propanol production via a CO–CO₂ coupling pathway.

Yanming Cai
Ruixin Yang
Wenlei Zhu
Research07 Jun 2024
Nature Synthesis

Volume: 3, P: 891-902
Bioelectronic Interfaces and Sensors for Neural Organoids

Qifei Wang
Xin Dong
Liujing Zhuang
ReviewsOpen Access15 Sept 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-27
Consummating ion desolvation in hard carbon anodes for reversible sodium storage

Hard carbon is regarded as a promising negative electrode for Na-ion batteries but suffers from low initial Coulombic efficiency (ICE). Here, the authors identify the time-dependent ion pre-desolvation on the nanopore of hard carbons, which remarkably improves the ICE by simply extending the aging time.

Ziyang Lu
Huijun Yang
Haoshen Zhou
ResearchOpen Access25 Apr 2024
Nature Communications

Volume: 15, P: 1-13
Unleashing the potential of noncanonical amino acid biosynthesis to create cells with precision tyrosine sulfation

Incorporation of noncanonical amino acids into proteins holds great promise for altering structure and function of these proteins. Here the authors generate metabolically modified prokaryotic and eukaryotic cells that can biosynthesize sTyr and incorporate it into proteins in a site-specific manner.

Yuda Chen
Shikai Jin
Han Xiao
ResearchOpen Access16 Sept 2022
Nature Communications

Volume: 13, P: 1-11
Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese

Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al.conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout.

Changgui Li
Zhiqiang Li
Yongyong Shi
ResearchOpen Access13 May 2015
Nature Communications

Volume: 6, P: 1-6
e_g occupancy as an effective descriptor for the catalytic activity of perovskite oxide-based peroxidase mimics

The search for peroxidase-like as well as other enzyme-like nanozymes mainly relies on trial-and-error strategies, due to the lack of predictive descriptors. Here, the authors fill this gap by investigating the occupancy of e_g orbitals as a possible descriptor for the peroxidase-like activity of transition metal oxide nanozymes

Xiaoyu Wang
Xuejiao J. Gao
Hui Wei
ResearchOpen Access11 Feb 2019
Nature Communications

Volume: 10, P: 1-8
Searching for topological Fermi arcs via quasiparticle interference on a type-II Weyl semimetal MoTe₂

Davide Iaia
Guoqing Chang
Vidya Madhavan
ResearchOpen Access20 Aug 2018
npj Quantum Materials

Volume: 3, P: 1-6
Anion-controlled dimer distance induced unique solid-state fluorescence of cyano substituted styrene pyridinium

Gaobin Zhang
Xuanjun Zhang
Jiaxiang Yang
ResearchOpen Access21 Nov 2016
Scientific Reports

Volume: 6, P: 1-9
Integrative multi-omics data provide insights into the biosynthesis of furanocoumarins and mechanisms regulating their accumulation in Angelica dahurica

A multi-omics study of Angelica dahurica identifies CYP71AZ18/19 and CYP83F95 that catalyze bergaptol/xanthotoxol biosynthesis and are encoded by genes which underwent lineage-specific proximal duplication-neofunctionalization as well as exhibit high chromatin accessibility.

Jiaojiao Ji
Xiaoxu Han
Li Wang
ResearchOpen Access23 Apr 2025
Communications Biology

Volume: 8, P: 1-15
Author Correction: Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells

Longfei Gao
Shichao Huang
Gang Pei
Amendments and CorrectionsOpen Access14 Feb 2020
Scientific Reports

Volume: 10, P: 1
Hybrid multimodal wearable sensors for comprehensive health monitoring

This Review examines the development and potential of wearable sensor systems that use multiple physical and chemical sensing modalities to assess human health.

Kuldeep Mahato
Tamoghna Saha
Joseph Wang
Reviews23 Sept 2024
Nature Electronics

Volume: 7, P: 735-750
Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells

Longfei Gao
Shichao Huang
Gang Pei
ResearchOpen Access05 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
Insulin detection in diabetes mellitus: challenges and new prospects

An urgent need exists for technologies and devices capable of frequent and real-time insulin measurements in patients with diabetes mellitus to guide optimal insulin dosing. This Perspective discusses the advances and challenges in moving insulin assays from laboratory-based assays to frequent and continuous measurements in decentralized settings.

Eva Vargas
Ponnusamy Nandhakumar
Joseph Wang
Reviews22 May 2023
Nature Reviews Endocrinology

Volume: 19, P: 487-495
Arm race among closely-related carbapenem-resistant Klebsiella pneumoniae clones

Ying Liu
Shichao Zhu
Zhiyong Zong
ResearchOpen Access22 Aug 2022
ISME Communications

Volume: 2, P: 1-12
Uptake and translocation of polycyclic aromatic hydrocarbons (PAHs) and heavy metals by maize from soil irrigated with wastewater

Shichao Zhang
Hong Yao
Dayi Zhang
ResearchOpen Access22 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age

Leilei Wu
Shichao Pang
Yixue Li
ResearchOpen Access14 Jun 2017
Scientific Reports

Volume: 7, P: 1-10
Theoretical design of multi-colored semi-transparent organic solar cells with both efficient color filtering and light harvesting

Long Wen
Qin Chen
Yan Yu
ResearchOpen Access13 Nov 2014
Scientific Reports

Volume: 4, P: 1-8

Search

Electron-density-informed effective and reliable de novo molecular design and optimization with ED2Mol

Integration of chemical and physical inputs for monitoring metabolites and cardiac signals in diabetes

Dyna-vivo-seq unveils cellular RNA dynamics during acute kidney injury via in vivo metabolic RNA labeling-based scRNA-seq

Well-TEMP-seq as a microwell-based strategy for massively parallel profiling of single-cell temporal RNA dynamics

A fingertip-wearable microgrid system for autonomous energy management and metabolic monitoring

Patterns and driving forces of dimensionality-dependent charge density waves in 2H-type transition metal dichalcogenides

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases

Self-pressurizing nanoscale capsule catalysts for CO₂ electroreduction to acetate or propanol

Bioelectronic Interfaces and Sensors for Neural Organoids

Consummating ion desolvation in hard carbon anodes for reversible sodium storage

Unleashing the potential of noncanonical amino acid biosynthesis to create cells with precision tyrosine sulfation

Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese

e_g occupancy as an effective descriptor for the catalytic activity of perovskite oxide-based peroxidase mimics

Searching for topological Fermi arcs via quasiparticle interference on a type-II Weyl semimetal MoTe₂

Anion-controlled dimer distance induced unique solid-state fluorescence of cyano substituted styrene pyridinium

Integrative multi-omics data provide insights into the biosynthesis of furanocoumarins and mechanisms regulating their accumulation in Angelica dahurica

Author Correction: Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells

Hybrid multimodal wearable sensors for comprehensive health monitoring

Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells

Insulin detection in diabetes mellitus: challenges and new prospects

Arm race among closely-related carbapenem-resistant Klebsiella pneumoniae clones

Uptake and translocation of polycyclic aromatic hydrocarbons (PAHs) and heavy metals by maize from soil irrigated with wastewater

Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age

Theoretical design of multi-colored semi-transparent organic solar cells with both efficient color filtering and light harvesting

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