Mutations in the TP53 gene are linked to cancer progression and drug resistance. Here, the authors show that mutant p53 inhibits stress granule formation, leading to increased apoptosis and enhanced sensitivity to the ER stress-inducing chemotherapy drug sorafenib in preclinical models of hepatocellular carcinoma.
- Elizabeth Thoenen
- Atul Ranjan
- Tomoo Iwakuma
