Nature Search

Uncertainty-aware ensemble of foundation models differentiates glioblastoma from its mimics

Distinguishing glioblastoma and primary central nervous system lymphoma (PCNSL) remains challenging due to their overlapping pathology features. Here, the authors develop a computational tool, PICTURE, for differentiating similar pathological features enabling improved diagnosis of CNS tumours.

Junhan Zhao
Shih-Yen Lin
Kun-Hsing Yu
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Tubulin isotypes of C. elegans harness the mechanosensitivity of the lattice for microtubule luminal accessibility

Proteins interact with both the exterior and interior of microtubules. Here the relationship between microtubule building blocks and the accessibility of the microtubule interior to proteins is clarified.

Yucheng Ye
Zheng Hao
Shih-Chieh Ti
Research26 Aug 2025
Nature Physics

Volume: 21, P: 1420-1430
The behavioral signature of stepwise learning strategy in male rats and its neural correlate in the basal forebrain

How animals learn that reward is predicted by multi-event sequences consisting of sensory stimuli and actions remains poorly understood. Here, the authors show that such learning starts from the event closest to the reward and sequentially incorporates earlier events.

Hachi E. Manzur
Ksenia Vlasov
Shih-Chieh Lin
ResearchOpen Access21 Jul 2023
Nature Communications

Volume: 14, P: 1-15
Erratum: Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Chen-Chi Liu
Shih-Pei Lin
Shih-Chieh Hung
Amendments and CorrectionsOpen Access22 Dec 2016
Nature Communications

Volume: 7, P: 1-4
The relationship between tissue inhibitor of metalloproteinases-1 and KCNJ5 mutation in aldosterone-producing adenoma patients

No-Ting Lin
Tsung-Yan Chen
Ying-Ying Chen
Research17 Dec 2024
Hypertension Research

Volume: 48, P: 563-573
Correction: YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer

Hsiu-Chi Lee
Chien-Hui Ou
Shih-Chieh Lin
Amendments and Corrections19 May 2021
Oncogene

Volume: 40, P: 4060
Photochemical diazidation of alkenes enabled by ligand-to-metal charge transfer and radical ligand transfer

The difunctionalization of alkenes allows for efficient construction of molecular complexity. Combining Ligand-to-Metal Charge transfer (LMCT) and Radical Ligand Transfer (RLT), the authors show a photochemical diazidation using iron salts, allowing rapid preparation of vicinal diamines and other privileged synthetic motifs.

Kang-Jie Bian
Shih-Chieh Kao
Julian G. West
ResearchOpen Access23 Dec 2022
Nature Communications

Volume: 13, P: 1-10
Wide-range and area-selective threshold voltage tunability in ultrathin indium oxide transistors

The doping and threshold voltage modulation of 2D transistors remain challenging. Here, the authors report a wafer-scale optical-thermal method combining ultraviolet illumination and oxygen annealing to tune the threshold voltage of atomic-layer-deposited In₂O₃ transistors with 2 nm thickness.

Robert Tseng
Sung-Tsun Wang
Der-Hsien Lien
ResearchOpen Access28 Aug 2023
Nature Communications

Volume: 14, P: 1-8
Collagen-binding peptides for the enhanced imaging, lubrication and regeneration of osteoarthritic articular cartilage

Collagen-binding peptides identified via phage display can be used to enhance the homing of mesenchymal stem cells to osteoarthritic tissue, its lubrication by hyaluronic acid and its visualization via magnetic resonance imaging.

Chin-Yu Lin
Yung-Li Wang
Shih-Chieh Hung
Research13 Oct 2022
Nature Biomedical Engineering

Volume: 6, P: 1105-1117
Topically Applied Cross-Linked Hyaluronan Attenuates the Formation of Spinal Epidural Fibrosis in a Swine Model of Laminectomy

Cheng-Li Lin
I-Ming Jou
Yi-Hung Huang
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Basal forebrain neuronal inhibition enables rapid behavioral stopping

How does the brain stop a planned action that has suddenly become inappropriate? Here, Mayse et al. identify a novel subcortical mechanism of inhibitory control in the basal forebrain outside the canonical fronto-basal-ganglia circuit. Basal forebrain neuronal inhibition enables rapid behavioral stopping and also determines its speed.

Jeffrey D Mayse
Geoffrey M Nelson
Shih-Chieh Lin
Research14 Sept 2015
Nature Neuroscience

Volume: 18, P: 1501-1508
Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells

Tumour initiating cells (TICs) are anoikis resistant in suspension culture and they are critical for initiating tumorigenesis in vivo. Here, the authors show that these features are promoted by hemidesmosome-like structures enriched in laminin V and collagen XVII 5 upregulated in TICs by phospho-STAT3 whose levels are increased through PP2A inactivation.

Chen-Chi Liu
Shih-Pei Lin
Shih-Chieh Hung
ResearchOpen Access16 Jun 2016
Nature Communications

Volume: 7, P: 1-19
Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer

The orphan nuclear receptor COUP-TFII is highly expressed in metastatic prostate cancers and its overexpression accelerates prostate tumour progression in mouse models. Here, the author show that that loss of miR-101 and miR-27a in prostate cancer cells can lead to COUP-TFII expression which in turn directly regulates FOXM1 and CENPFfavouring prostate cancer metastasis.

Shih-Chieh Lin
Chung-Yang Kao
Ming-Jer Tsai
ResearchOpen Access25 Apr 2016
Nature Communications

Volume: 7, P: 1-14
Element- and momentum-resolved electronic structure of the dilute magnetic semiconductor manganese doped gallium arsenide

The knowledge of the electronic structure of composite material is essential for tailoring their properties. The authors introduce a method based on standing wave angle-resolved hard X-ray photoemission to determine the element- and momentum-resolved electronic band structure simultaneously.

Slavomír Nemšák
Mathias Gehlmann
Charles S. Fadley
ResearchOpen Access17 Aug 2018
Nature Communications

Volume: 9, P: 1-8
Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients

TDP-43 proteinopathies are characterized by TDP-43 aggregates but the relationship of these aggregates to the pathogenesis is still not well defined. Here, the authors show that the recombinant full-length human TDP-43 forms oligomers that are neurotoxic, can promote the formation of A-beta amyloid oligomers in vitroand can be detected in postmortem brain of patients.

Yu-Sheng Fang
Kuen-Jer Tsai
Yun-Ru Chen
Research12 Sept 2014
Nature Communications

Volume: 5, P: 1-13
Autonomous cortisol secretion promotes vascular calcification in vivo and in vitro under hyperaldosteronism

Bo-Ching Lee
Chin-Chen Chang
Ying-Ying Chen
Research08 Nov 2024
Hypertension Research

Volume: 48, P: 366-377
Involvement of ER stress, PI3K/AKT activation, and lung fibroblast proliferation in bleomycin-induced pulmonary fibrosis

Han-Shui Hsu
Chen-Chi Liu
Shih-Chieh Hung
ResearchOpen Access27 Oct 2017
Scientific Reports

Volume: 7, P: 1-11
Using rare earth elements to constrain particulate organic carbon flux in the East China Sea

Chin-Chang Hung
Ya-Feng Chen
David J. Burdige
ResearchOpen Access27 Sept 2016
Scientific Reports

Volume: 6, P: 1-9
The long noncoding RNA lncZBTB10 facilitates AR function via S-palmitoylation to promote prostate cancer progression and abiraterone resistance

Shin-Chih Lin
Yu-Sheng Cheng
Shih-Chieh Lin
Research16 Feb 2025
British Journal of Cancer

Volume: 132, P: 587-598
Evaluating the effects of adrenalectomy and mineralocorticoid receptor antagonist on cardiac remodeling and diastolic function in patients with aldosterone-producing adenoma

Yu-Ching Chang
Xue-Ming Wu
Ying-Ying Chen
Research25 Oct 2024
Hypertension Research

Volume: 48, P: 529-539
p53 activates transcription by directing structural shifts in Mediator

While activators must impact the Mediator complex to promote transcription, the mechanisms that underpin this are currently unclear. The effects of p53 domain-binding on transcription and mediator structures now argue that a pocket, similar in size to one previously seen upon SREBP binding, may be a feature of an activated Mediator complex.

Krista D Meyer
Shih-chieh Lin
Dylan J Taatjes
Research09 May 2010
Nature Structural & Molecular Biology

Volume: 17, P: 753-760
Speculating suitability of partial adrenalectomy for lateralized primary aldosteronism: With emphasis on partial and complete success as optimistic outcomes

Our results show that unilateral partial adrenalectomy is not a good surgical option for the majority of lateralized PA patients. In clinically lateralized PA patients, no matter which group they are in the HISTALDO classification, they would benefit from unilateral total adrenalectomy.

Tsae-Ni Lee
Chin-Chen Chang
Ying-Ying Chen
ResearchOpen Access03 Mar 2025
Hypertension Research

Volume: 48, P: 1739-1748
Myosteatosis and sarcopenia are linked to autonomous cortisol secretion in patients with aldosterone-producing adenomas

Bo-Ching Lee
Yu-Ling Chang
Ying-Ying Chen
ResearchOpen Access14 Oct 2024
Hypertension Research

Volume: 48, P: 519-528
Aldosteronism is associated with more severe cerebral small vessel disease in hypertensive intracerebral hemorrhage

Bo-Ching Lee
Hsin-Hsi Tsai
Ying-Ying Chen
Research22 Nov 2023
Hypertension Research

Volume: 47, P: 608-617
YAP1 overexpression contributes to the development of enzalutamide resistance by induction of cancer stemness and lipid metabolism in prostate cancer

Hsiu-Chi Lee
Chien-Hui Ou
Shih-Chieh Lin
ResearchOpen Access04 Mar 2021
Oncogene

Volume: 40, P: 2407-2421
New-onset diabetes mellitus risk associated with concurrent autonomous cortisol secretion in patients with primary aldosteronism

Vin-Cent Wu
Chieh-Kai Chan
Vin-Cent Wu
Research08 Dec 2022
Hypertension Research

Volume: 46, P: 445-455
Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation

Chia-Chen Ku
Kenly Wuputra
Kazunari K. Yokoyama
ResearchOpen Access18 Mar 2020
Scientific Reports

Volume: 10, P: 1-14
Correction: Corrigendum: Long term outcome of Aldosteronism after target treatments

Vin-Cent Wu
Shuo-Meng Wang
Kwan-Dun Wu
Amendments and CorrectionsOpen Access24 Mar 2017
Scientific Reports

Volume: 7, P: 1
Long term outcome of Aldosteronism after target treatments

Vin-Cent Wu
Shuo-Meng Wang
Kwan-Dun Wu
ResearchOpen Access02 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
The hOGG1 Ser³²⁶Cys gene polymorphism is associated with decreased insulin sensitivity in subjects with normal glucose tolerance

Chiao-Ling Wang
Ming-Chia Hsieh
Shyi-Jang Shin
Research01 Feb 2006
Journal of Human Genetics

Volume: 51, P: 124-128
Quantitative PPARγ expression affects the balance between tolerance and immunity

Ya-Hui Liu
Yau-Sheng Tsai
Pei-Jane Tsai
ResearchOpen Access25 May 2016
Scientific Reports

Volume: 6, P: 1-13
Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D₂ and adenosine A_2A receptors

Chien-Yu Lin
Hsing-Lin Lai
Yijuang Chern
ResearchOpen Access27 Aug 2019
Translational Psychiatry

Volume: 9, P: 1-13
Author Correction: Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation

Chia-Chen Ku
Kenly Wuputra
Kazunari K. Yokoyama
Amendments and CorrectionsOpen Access12 Jun 2020
Scientific Reports

Volume: 10, P: 1-2
Glutathione peroxidase 4 expression predicts poor overall survival in patients with resected lung adenocarcinoma

Chao-Yu Liu
Chen-Chi Liu
Han-Shui Hsu
ResearchOpen Access28 Nov 2022
Scientific Reports

Volume: 12, P: 1-10
Indolent enhancing spinal lesions mimicking spinal metastasis in pediatric patients with malignant primary brain tumors

Hsin-Wei Wu
Shih-Chieh Lin
Feng-Chi Chang
ResearchOpen Access02 Feb 2022
Scientific Reports

Volume: 12, P: 1-10
Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure

Chih-Hsuan Yen
Jiun-Lu Lin
Hung-I. Yeh
ResearchOpen Access13 Aug 2021
Scientific Reports

Volume: 11, P: 1-13
Hemojuvelin Predicts Acute Kidney Injury and Poor Outcomes Following Cardiac Surgery

Sheng-Wen Ko
Nai-Hsin Chi
Tzong-Shinn Chu
ResearchOpen Access31 Jan 2018
Scientific Reports

Volume: 8, P: 1-11
Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development

Hui-Ju Lee
Chung-Yang Kao
Ming-Jer Tsai
ResearchOpen Access09 Jun 2017
Scientific Reports

Volume: 7, P: 1-10
The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes

Vin-Cent Wu
Shuo-Meng Wang
Kwan-Dun Wu
ResearchOpen Access19 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Thyroid transcription factor-1 distinguishes subependymal giant cell astrocytoma from its mimics and supports its cell origin from the progenitor cells in the medial ganglionic eminence

Jen-Fan Hang
Chih-Yi Hsu
Donald Ming-Tak Ho
Research02 Dec 2016
Modern Pathology

Volume: 30, P: 318-328

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