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Showing 1–7 of 7 results

Advanced filters: Author: Shiya Cheng Clear advanced filters

Nuclear pore passage of the HIV capsid is driven by its unusual surface amino acid composition

Fu et al. uncover the features that allow the HIV capsid to cross the permeability barrier of nuclear pores in an importin-independent manner, explaining how the viral genome can reach the nuclear compartment when infecting nondividing cells.

Liran Fu
Shiya Cheng
Dirk Görlich
ResearchOpen Access09 Oct 2025
Nature Structural & Molecular Biology

Volume: 32, P: 2476-2491
Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes

How translation of M-phase promoting factors is blocked in immature oocytes is poorly understood. Here, the authors show 4E-T suppresses cyclin-B and c-Mos translation, preventing oocytes from maturing spontaneously without hormonal stimulation.

Andreas Heim
Shiya Cheng
Thomas U. Mayer
ResearchOpen Access28 Aug 2025
Nature Communications

Volume: 16, P: 1-17
Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes

Mammalian oocytes must be maintained in prophase long enough to grow to full size. Here, the authors identify two mechanisms that repress cyclin B1 translation to maintain prophase arrest, and reveal a new aspect of cytoplasmic poly(A)-binding proteins in controlling translation.

Shiya Cheng
Melina Schuh
ResearchOpen Access20 Nov 2024
Nature Communications

Volume: 15, P: 1-18
HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor

The HIV-1 capsid behaves like a nuclear transport receptor entering and traversing an FG phase, with its interior serving as a cargo container, bypassing an otherwise effective barrier to viral infection.

Liran Fu
Erika N. Weiskopf
Dirk Görlich
ResearchOpen Access24 Jan 2024
Nature

Volume: 626, P: 843-851
The maintenance of oocytes in the mammalian ovary involves extreme protein longevity

Harasimov, Gorry, Welp, Penir, Horokhovskyi et al. analyse proteostasis in mammalian oocytes and ovaries: the maintenance of oocytes involves exceptional protein longevity, and many of the extremely long-lived proteins decline as the ovary ages.

Katarina Harasimov
Rebecca L. Gorry
Melina Schuh
ResearchOpen Access20 Jun 2024
Nature Cell Biology

Volume: 26, P: 1124-1138
CD8⁺ TILs in necrotic tumors after neoadjuvant immunochemotherapy predict outcomes in non-small-cell lung cancer patients

Haifeng Lin
Yi Han
Hezhe Lu
ResearchOpen Access09 Oct 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-10
A spatial transcriptomics study of MES-like and mono/macro cells in gliomas

Boyan Zhao
Jianing Wu
Shiguang Zhao
ResearchOpen Access13 Apr 2025
Scientific Reports

Volume: 15, P: 1-21