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Showing 1–5 of 5 results
Advanced filters: Author: Shouhong Jin Clear advanced filters

  • Piwi-interacting RNAs (piRNAs) are vital for genome integrity and fertility. Here the authors reveal that spatial clustering of piRNA genes in Caenorhabditis elegans promotes transcription through phase separation and deSUMOylation, uncovering a SUMOylation-regulated mechanism for piRNA production in heterochromatic genomes.

    • Chengming Zhu
    • Xiaoyue Si
    • Shouhong Guang
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1503-1516

  • Determining structures of small, protein-free RNAs by cryo-EM has been challenging. Here, the authors use a group II intron scaffold to achieve high-resolution RNA structures, visualize ligand-induced changes, and enable de novo modeling of non-coding RNAs.

    • Daniel B. Haack
    • Boris Rudolfs
    • Navtej Toor
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Zhang et al. construct a large-scale CT image dataset with fine pixel-level annotations for both normal tissue and rectal cancer tumors. Additionally, they propose a clinically applicable method named U-SAM to assist doctors in segmenting normal tissues and rectal cancer areas and validate its effectiveness.

    • Hantao Zhang
    • Weidong Guo
    • Jiancheng Yang
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-11

  • Germ granules help to maintain germ cell totipotency. Here, authors identify a distinct subcompartment of the C. elegans germ granule, the E granule, and show that defects in its assembly elicit disordered production of endogenous siRNAs that disturbs fertility and the RNAi response.

    • Xiangyang Chen
    • Ke Wang
    • Shouhong Guang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19