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Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

Integrating the Pancharatnam–Berry phase with integrated resonant nanoantennas in a metalens design produces an achromatic device capable of full-colour imaging in the visible range in transmission mode.

Designing efficient light-emitting diodes with full-color-tunability and white-light-emission remains a challenge. Here, the authors demonstrate a multifunctional hybrid tandem LED by stacking a yellow quantum-dot LED with a blue organic LED using an indium–zinc oxide intermediate connecting electrode.

Asymmetric nickel catalysis is used to intercept transient cyclic allene intermediates to achieve stereocontrol.

A metalens array of GaN nanoantennas is used to make a full-colour achromatic light-field camera.

Minor changes to complex structures can exert major influences on synthesis strategy and functional properties but synthetic difficulties can obstruct the exploration of natural product function. Here the authors explore two parallel series of picrotoxinin analogs and identify leads with selectivity between mammalian and insect ion channels.

Electrically pumped and surface-emitting ASE from solution-casted colloidal QDs has been demonstrated by electro-thermal-optically co-designing of a QLED with high optical gain and large current injection.

The amination of C–H bonds is a sustainable approach to prepare important nitrogen-containing molecules; however, regio- and stereoselectivity is difficult to control. Now the synthesis of α-monosubstituted and α,α-disubstituted α-amino acids from abundant carboxylic acids has been achieved through Fe-catalysed asymmetric intermolecular C(sp³)–H amination by directed stereocontrolled nitrene insertion.

A straightforward method for synthesizing optically active α-amino acids from abundant carboxylic acids has been developed. Based on a nitrene-mediated stereocontrolled 1,3-nitrogen shift, this approach provides access to a large variety of unnatural α-amino acids with aryl, allyl, propargyl and alkyl side chains and enables late-stage amination of carboxylic-acid-containing drugs.

The synthesis of polycyclic structures bearing partially saturated (hetero)arenes is important as many of these structures have biological relevance. Here the authors develop a one-step method for selective dearomative functionalization of feedstock (hetero)arenes via organophotocatalysis.

Su et al. report a single photon counting technique to trace the electron transport paths at different voltages for QLEDs, revealing the leakage electrons into the hole transport layer or recombination at the interface, providing unambiguous understanding in the device operation and degradation mechanism.

A naturally occurring stand-alone and intermolecular Diels–Alderase, MaDA, has been identified from Morus alba cell cultures. MaDA is a FAD-dependent enzyme, which catalyses the intermolecular [4+2] cycloaddition via a concerted but asynchronous pericyclic pathway between morachalcone A and a diene generated from moracin C. Characterization revealed that MaDA possesses good substrate promiscuity towards both dienes and dienophiles.

How holes are injected into quantum dots at sub-bandgap bias has puzzled researchers for years. Here, authors show, using temperature-dependent electroluminescence (EL) and theoretical analysis, such injection occurs via thermal-assisted thermionic-emission, consequently enabling the sub-bandgap turn-on and up-conversion EL.

Hybrid 2D/3D ring systems have emerged as important scaffolds in medicinal chemistry, but efficient protocols for their synthesis are scarce. Now, energy-transfer-mediated cascade dearomative [2 + 2] cycloaddition/rearrangement reactions are developed to provide facile access to pyridine-fused 2D/3D ring systems.

Metasurfaces suffer from large chromatic aberration due to the high phase dispersion of their building blocks, limiting their applications. Here, Wang et al. design achromatic metasurface devices which eliminate the chromatic aberration over a continuous region from 1200 to 1680 nm in a reflection schleme.

Through rational engineering of A3A deaminase, Yang and colleagues have designed CBEs termed haA3A-CBEs, which feature a condensed editing window and minimal off-target effects that are independent of defined sequence contexts and methylation status.

Conventional lighting requires an AC-DC converter for LEDs. Here, the authors report a tandem structure by connecting two QLEDs with opposite polarity in parallel, enabling AC driven operation. A household AC electricity plug-and-play QLEDs panel with tuneable colour and brightness is achieved.

The authors report a Cu/Cu₂Se-Cu₂O heterojunction nanosheet array which show cases efficient CO₂ reduction to ethanol using solar energy through a confluence of effects stemming from the catalyst heterostructure and including photothermal and confinement effects.

The neural circuits through which the substantia nigra pars reticulata (SNr) exerts its role in epilepsy control are not known. Here the authors reveal that a long-range SNr-parafascicular nucleus disinhibitory circuit participates in regulating seizures in temporal lobe epilepsy and inhibition of this circuit can alleviate severity of epileptic seizures.

A new class of quantum dots with a soft core and a compressive shell has optical and electronic properties that can be tuned by strain.

Boronic acids are useful reagents in organic synthesis and thus methods to prepare these compounds under mild conditions are desirable. Here, the authors synthesize boronic acids via photocatalytic decarboxylation of benzoic acids followed by borylation; guanidine-type additives are used to assist the process.

Targeting TBK1 is an effective strategy to overcome resistance to cancer immunotherapy.

Although biaryl rings can be easily formed via cross coupling, their tetrahedral, high-fraction sp³ equivalents cannot. Now the scope, mechanism and biological profile of a general attached-ring synthesis has been probed. This provides direct access to full bridgehead substitution via sp³–sp³ coupling and enables rapid entry to natural product space.

Base editors that modify both adenine and cytosine broaden the potential applications of base editing.

mRNA that contains a premature termination codon (PTC) triggers a genetic compensation response that involves both transcription of its homologous genes and degradation of the mutated transcript by the nonsense-mediated decay pathway.

High performance and multifunctional tandem QLED is achieved by face-to-face integrating a top-emitting QLED with a transparent QLED, which exhibits a record-breaking EQE of 60.7% and can operate in series, parallel, and color-tunable modes.

New evidence suggests that the mechanism of nanoparticle entry into solid tumours may be driven by an active process. This insight paves the way for approaches to enhance the efficiency of nanomedicine delivery by harnessing active transport mechanisms, and encourage researchers to rethink how tumours are treated.

Li and colleagues report base editor variants with improved targeting efficiencies and broader editing windows by fusing the original base editors with the single-stranded DNA-binding domain of Rad51.