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Showing 1–12 of 12 results
Advanced filters: Author: Sichen Shao Clear advanced filters

  • To celebrate the journal’s 25th anniversary, we asked 13 researchers to offer a glimpse of what their research field might look like in 2050. They consider how technological breakthroughs — for example, artificial intelligence-powered virtual cells — could transform our understanding of how molecules, organelles and cells behave in different contexts, revolutionize therapies and enable the design of resilient crops.

    • Monther Abu-Remaileh
    • Chii Jou Chan
    • Jan J. Żylicz
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 26, P: 735-740

  • Gao, Nardone et al. report the cryo-EM structure of human TXNL1 bound to the proteasome and reveal interactions required for the stress-induced degradation of TXNL1, an abundant protein that may regulate proteasomal activity.

    • Jingjing Gao
    • Christopher Nardone
    • Sichen Shao
    ResearchOpen Access
    Nature Structural & Molecular Biology
    P: 1-5

  • CDAN1 is an essential protein with unclear function that binds the histone chaperone ASF1. Here, the authors reveal that CDAN1 sequesters multiple copies of ASF1 by engaging all binding sites known to facilitate histone chaperoning.

    • Samantha F. Sedor
    • Sichen Shao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • The small molecule SRI-41315 induces the degradation of the translation termination factor eRF1 to enhance stop codon readthrough. Coelho, Yip et al. reveal that SRI-41315 is a metal-dependent molecular glue that traps eRF1 on terminating ribosomes.

    • João P. L. Coelho
    • Matthew C. J. Yip
    • Sichen Shao
    Research
    Nature Chemical Biology
    Volume: 20, P: 877-884

  • Functional assays and cryo-EM structures show that ubiquitin binding and a cofactor drive protein quality-control client selection by the hybrid E2/E3 enzyme UBE2O.

    • Matthew C. J. Yip
    • Samantha F. Sedor
    • Sichen Shao
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 774-780

  • The efficacy of anticancer gene therapy varies by the delivery efficiency of the mRNA cargo as well as their injection method. Here this group reports using LNP-delivered mRNA encoding 3 C protease treated on three different types of solid tumor models showing effective tumor growth inhibition, with three different injection methods, respectively.

    • Xiaotong Yang
    • Wei Li
    • Wu Zhong
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • During ribosome-associated quality control (RQC), ANKZF1 severs polypeptidyl-tRNAs on RQC complexes by cleaving the terminal 3′CCA nucleotides, which leads to tRNA fragments that are ‘quality checked’ and recycled in the cytosol.

    • Matthew C. J. Yip
    • Alexander F. A. Keszei
    • Sichen Shao
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 343-349

  • Cryo-EM structures of the cytosolic metazoan GET complex, which targets nascent tail-anchored membrane proteins to the endoplasmic reticulum, reveal interactions that coordinate client transfer between two protein chaperones.

    • Alexander F. A. Keszei
    • Matthew C. J. Yip
    • Sichen Shao
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 1029-1037

  • Through structural analysis of the activation of bacterial STING, the molecular basis of STING filament formation and TIR effector domain activation in antiphage signalling is defined.

    • Benjamin R. Morehouse
    • Matthew C. J. Yip
    • Philip J. Kranzusch
    ResearchOpen Access
    Nature
    Volume: 608, P: 803-807

  • Structures of prokaryotic homologues of STING permit the reconstruction of the evolutionary trajectory of its incorporation into metazoan innate immunity, and reveal a role for the conserved cGAS–STING pathway in prokaryotic defence against bacteriophages.

    • Benjamin R. Morehouse
    • Apurva A. Govande
    • Philip J. Kranzusch
    Research
    Nature
    Volume: 586, P: 429-433

  • Biochemical and structural analysis demonstrate that simultaneous detection of poly-lysine in the exit tunnel and poly(A) in the decoding center allows ribosomes to detect aberrant mRNAs, stall elongation and trigger downstream quality control pathways.

    • Viswanathan Chandrasekaran
    • Szymon Juszkiewicz
    • Ramanujan S. Hegde
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 1132-1140

  • All eukaryotes utilize a single termination factor, eRF1, to halt translation when the ribosome encounters one of three possible stop codons; here electron cryo-microscopy structures of ribosome–eRF1 complexes in the process of recognizing each stop codon reveal how stop codons are discriminated from sense codons.

    • Alan Brown
    • Sichen Shao
    • V. Ramakrishnan
    Research
    Nature
    Volume: 524, P: 493-496