Nature Search

Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

The apelin receptor regulates heart and metabolic health via G-protein and β-arrestin signaling pathways. Here, authors present receptor-β-arrestin complex structures with distinct stoichiometries that provide insight into biased signaling, guiding targeted drug design.

Yang Yue
Chanjuan Xu
Fei Xu
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Identification of druggable regulators of cell secretion via a kinome-wide screen and high-throughput immunomagnetic cell sorting

A high-throughput microfluidic method for the analysis of the secretion levels of large populations of immune cells allows for the identification of kinase-coding genes regulating interferon-gamma secretion by CD4⁺ T cells.

Mahmoud Labib
Zongjie Wang
Shana O. Kelley
Research27 Nov 2023
Nature Biomedical Engineering

Volume: 8, P: 263-277
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

The oncogene KRAS is frequently mutated in cancer, including colorectal cancer. Here, using a cell-surface proteomics approach, KRAS-mutated colorectal cancer cells are shown to express high levels of the copper transporter ATP7A, which has an essential roles in cancer cell survival and proliferation.

Léo Aubert
Neethi Nandagopal
Philippe P. Roux
ResearchOpen Access24 Jul 2020
Nature Communications

Volume: 11, P: 1-15
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

In patients with melanoma, increased RAS/mitogen-activated protein kinase (MAPK) pathway activity is known to drive chemotherapy resistance. Here, the authors identify CDK12 as a downstream effector of the RAS/MAPK pathway and therapeutic target which mediates chemotherapy resistance through increased expression of DNA repair associated genes.

Thibault Houles
Geneviève Lavoie
Philippe P. Roux
ResearchOpen Access29 Oct 2022
Nature Communications

Volume: 13, P: 1-16
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction

A small-molecule activator of Wnt/β-catenin signaling acts by binding a negative regulator of β-catenin, Axin, leading to a conformational change that promotes association of Axin with LRP6.

Sheng Wang
Junlin Yin
Lin Li
Research28 Jul 2013
Nature Chemical Biology

Volume: 9, P: 579-585
TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

Alice H. L. Bong
Mélanie Robitaille
Gregory R. Monteith
ResearchOpen Access01 Oct 2024
Cell Death Discovery

Volume: 10, P: 1-12
The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

Thibault Houles
Jonathan Boucher
Philippe P. Roux
ResearchOpen Access16 Dec 2023
Cell Death Discovery

Volume: 9, P: 1-9
Genome-wide analysis of DNA G-quadruplex motifs across 37 species provides insights into G4 evolution

Wu, Niu, Cui et al characterize G4 motifs across 37 species by bioinformatics, revealing that G4 complexity increases with evolution and as well as an antagonistic relationship between the potential G4s and DNA methylation sites.

Feng Wu
Kangkang Niu
Qili Feng
ResearchOpen Access22 Jan 2021
Communications Biology

Volume: 4, P: 1-11

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